Biomedical Science Letters

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Table. 1.

Functional characterization of XIST in human cancers

Cancer typeXIST expression levelXIST molecular target (s)Downstream genesEffect on cancer progression and metastasisFunctional role of XIST (oncogene/ tumor suppressor)References
Non-small-cell lung cancerUpregulatedmiR-367 and miR-141ZEB2⬆ TGF-β induced EMTOncogeneLi et al., 2018
UpregulatedmiR-137PXN/Notch-1⬆ ProliferationOncogeneJiang et al., 2018Wang et al., 2018
⬆ Invasion
UpregulatedmiR-186-5pUnknown⬆ Cell viabilityOncogeneWang et al., 2017a
⬆ Invasion
⬇ Apoptosis
UpregulatedmiR-449aBcl-2⬆ Cell proliferationOncogeneZhang et al., 2017
⬆ Cell migration and invasion
⬇ Apoptosis
UpregulatedmiR-374aLARP1⬆ Cell growthOncogeneXu et al., 2017b
⬆ Migration
⬆ Invasion
⬆ Tumorigenicity
UpregulatedEZH2KLF2⬆ Cell proliferationOncogeneFang et al., 2016
⬆ Migration
⬆ Invasion
⬆ Tumorigenicity Poor prognosis
UpregulatedmiR-17ATG7⬆ AutophagyOncogeneSun et al., 2017b
⬆ TNM stage
⬆ Chemoresistance
UpregulatedLet-7iBAG-1⬆ Resistance to cisplatinOncogeneSun et al., 2017a
UpregulatedmiR-140iASPP⬆ Cell proliferationOncogeneTang et al., 2017
⬇ Apoptosis
⬆ Metastasis

Colorectal and Gastric cancerUpregulatedmiR-185TGF-β1⬆ Cell growthOncogeneZhang et al., 2018
⬆ GC progression
UpregulatedmiR-34aWNT1/ β-catenin⬆ Cell proliferationOncogeneSun et al., 2018a
⬆ Invasion
UpregulatedmiR-137EZH2⬆ EMTOncogeneLiu et al., 2018a
⬆ Invasion
UpregulatedmiR-497MACC1⬆ Cell cycle progressionOncogeneMa et al., 2017b
⬆ Invasion
UpregulatedmiR-200b-3pZEB1⬆ Cell proliferationOncogeneChen et al., 2017
⬆ Invasion
⬆ EMT
⬆ Stemness
⬇ Overall survival
UpregulatedmiR-132-3pMAPK1⬆ Cell cycle progressionOncogeneSong et al., 2017
UpregulatedUnknownTS⬇ 5-FU cytotoxicity Poor therapeutic efficacyOncogeneXiao et al., 2017
UpregulationmiR-101EZH2⬆ Tumor aggressiveness Poor patient survivalOncogeneChen et al., 2016

Hepatic cancerUpregulatedmiR-194-5pMAPK1⬆ Cell proliferationOncogeneKong et al., 2018
⬆ Migrasion
⬆ Invation
DownregulatedmiR-181aPTEN⬇ Cell proliferationTumor suppressorChang et al., 2017
⬇ Invasion
UpregulatedmiR-139-5pPDK1⬆ Cell cycle progressionOncogeneMo et al., 2017
⬇ Apoptosis
DownregulatedmiR-92bSmad7⬇ Cell proliferationTumor suppressorZhuang et al., 2016
⬇ Metastasis

Breast cancerDownregulatedmiR-155CDX1⬇ Cell growthTumor suppressorZheng et al., 2018
⬇ Migration
⬇ Invasion
DownregulatedPHLPP1AKT⬇ Cell viabilityTumor suppressorHuang et al., 2016

GliomaUpregulatedmiR-137Rac1⬆ Cell proliferationOncogeneWang et al., 2017
⬆ Tumorigenesis
UpregulatedmiR-29cMSH6/SP1/ MGMT⬆ Chemoresistance to TMZOncogeneDu et al., 2017
UpregulatedmiR-137FOXC1/ZO-2⬆ AngiogenesisOncogeneYu et al., 2017
⬇ Blood-tumor permeability
UpregulatedmiR-429Unknown⬆ TumorigenicityOncogeneCheng et al., 2017
⬆ Angiogenesis
⬆ Metastasis
UpregulatedmiR-152KLF4⬆ Cell proliferationOncogeneYao et al., 2015
⬆ Migration
⬆ Invasion
⬇ Stemness

Pancreatic cancerUpregulatedmiR-34a-5pUnknown⬆ Cell proliferationOncogeneSun et al., 2018a
⬆ Migration
⬆ Invasion
⬇ Apoptosis
UpregulatedmiR-133aEGFR⬆ Cell proliferationOncogeneWei et al., 2017
⬇ Poor prognosis
UpregulatedmiR-140/ miR-124iASPP⬆ Cell cycle progressionOncogeneLiang et al., 2017
⬆ Cell proliferation Poor clinicopathological features

Bladder cancerUpregulatedmiR-200cUnknown⬆ Cancer stem cells clonality and self-renewal EMTOncogeneXu et al., 2018
UpregulatedmiR-124AR⬆ Cell proliferationOncogeneXiong et al., 2017
⬆ Invasion
⬆ Migration

Bladder cancerUpregulatedmiR-139-5pWnt1⬆ Cell growthOncogeneHu et al., 2017
⬆ Metastasis Worse patient survival

Cervical cancerUpregulatedmiR-200aFus⬆ Tumor progressionOncogeneZhu et al., 2018
⬆ Distant metastasis
⬆ Tumor size
⬆ FIGO stage

OsteosarcomaUpregulatedmiR-195-5pYAP⬆ Cell proliferationOncogeneYang et al., 2018
⬆ Invasion
⬆ EMT
⬆ Tumor growth Poor clinical prognosis
UpregulatedmiR-320bRAP2B⬆ Cell proliferationOncogeneLv et al., 2018
⬆ Invasion
DownregulatedmiR-21-5ppPDCD4⬇ Cell proliferationTumor suppressorZhang and Xia, 2017
⬇ EMT
⬇ Invasion
⬇ Overall survival
UpregulatedEZH2P21⬆ Cell proliferationOncogeneXu et al., 2017a
⬆ Cell cycle

Nasopharynx cancerUpregulatedmiR-491-5pNotch3⬆ Cell proliferationOncogeneCheng et al., 2018
⬆ Invasion
⬆ Tumor growth
⬇ Apoptosis
UpregulatedmiR-29cUnknown⬆ Cell proliferation OncogeneHan et al., 2017
⬆ Radioresistance
UpregulatedmiR-34a-5pE2F3⬆ Cell growth Poor patient survivalOncogeneSong et al., 2016
Biomed Sci Letters 2019;25:113-22 https://doi.org/10.15616/BSL.2019.25.2.113
© 2019 Biomed Sci Letters