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Chitinase 3-Like 1 (CHI3L1) Polymorphism Contributes to Visceral Obesity and Obesity-related Inflammation Induces Chi3l1 in Adipocytes
Biomed. Sci. Lett. 2018;24:23-29
Published online March 31, 2018;  https://doi.org/10.15616/BSL.2018.24.1.23
© 2018 The Korean Society For Biomedical Laboratory Sciences.

A Young Kim1, Hyun Woo Jeong1, Ji-Hae Lee1, Jin Kyu Choi2, Jeong Kee Kim3, Jae Sung Hwang3 and Dae-Bang Seo1,†

1Vital Beautie Research Division, Amorepacific R&D Center, Yongin 17074, Korea 2QA team, Aestura Corporation, Ansung 17573, Korea 3Department of Genetic Engineering & Graduate School of Biotechnology, College of Life Sciences, Kyung Hee University, Yongin 17104, Korea
Correspondence to: Dae-Bang Seo. Vital Beautie Research Division, Amorepacific R&D Center, Youngin 17074, Korea. Tel: +82-31-280-5975, Fax: +82-31-284-8392, e-mail: sdbang@amorepacific.com
Received November 29, 2017; Revised March 12, 2018; Accepted March 13, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Abdominal obesity is considered as one of the most risky factors governing the development of metabolic diseases. Here we identify that human chitinase 3-like 1 (CHI3L1, also called YKL-40 in human) single nucleotide polymorphism (SNP), rs883125, is associated with abdominal obesity in Korean women. Korean women subjects with the rs883125 G/G or C/G genotype present higher waist-hip ratio than subjects with C/C genotype suggesting that human subjects who G nucleotide substitution at the rs883125 tended to more accumulate intra-abdominal fat at the abdominal cavity. In addition, Chi3l1 gene expression is increased in adipose tissue from obese mice and pro-inflammatory cytokine enhances Chi3l1 expression in adipocytes, indicating that Chi3l1 is greatly related with obesity and obesity-induced pro-inflammatory responses. Taken together, the minor allele of rs883125 is associated with a higher prevalence of abdominal obesity in Korean women. These findings suggest that genotype of rs883125 can be a biomarker of incident abdominal obesity and abdominal obesity-related metabolic diseases.
Keywords : Chitinase 3-like 1, CHI3L1, YKL-40, SNP, Abdominal obesity, Korean women