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The Improving Effect of Gastrodia elata Blume on DSS-induced Colitis in Mice
Biomed. Sci. Lett. 2018;24:168-174
Published online September 30, 2018;  https://doi.org/10.15616/BSL.2018.24.3.168
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Eun-Mi Ahn* and Su-Jin Kim†,*

Department of Biotechnology and Convergence, DaeguHanny University, Gyeongsan 38453, Korea
Correspondence to: Su-Jin Kim. Department of Biotechnology and Convergence, DaeguHanny University, Gyeongsan 38453, Korea
Tel: +82-53-819-1389, Fax: +82-53-819-1389, e-mail: ksj1009@dhu.ac.kr
*Professor.
Received April 16, 2018; Revised September 1, 2018; Accepted September 13, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by abdominal pain, rectal bleeding and diarrhea. Gastrodia elata Blume (GE) has been used for the treatment of various diseases including neurodegenerative diseases and inflammatory disease. However, there has been no information on whether GE regulates intestinal inflammation. The aim of this study is to elucidate whether GE can protect against dextran sulfate sodium (DSS)-induced colitis in a mouse model. The colitis mice were induced by drinking water containing 5% DSS for 7 days. Body weight, colon length and clinical score were assessed to determine the effects on colitis. The levels of inflammatory cytokines, tumor necrosis factor (TNF)-α and interleukin (IL)-6 in colitis tissue were also measured. The results showed that mice administrated with DSS showed clinical signs including weight loss and reduced colon length. GE inhibited the DSS-induced loss of body weight and shortening of colon and increased Disease activity index score. Additionally, we observed that GE suppressed the levels of TNF-α and IL-6 in DSS-treated colon tissues. Collectively, these findings provide experimental evidence that GE might be a useful therapeutic agent for patients with UC.
Keywords : Gastrodia elata Blume, Ulcerative colitis, Dextran sulfate sodium, Tumor necrosis factor-α, Interleukin-6