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Comparison of Virulence between Five Strains of Cryptococcus Species Complex in a Rat Model
Biomed. Sci. Lett. 2018;24:183-195
Published online September 30, 2018;  https://doi.org/10.15616/BSL.2018.24.3.183
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Gyu-Nam Park1,*, Sun-Young Kim2,**, Hye-Ran Kim1,**, Bo-Kyung Jung1,*, Dong-Jun An3,**, Seung-Bok Hong4,*** and Kyung-Soo Chang1,†,***

1Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Korea
2Department of Pathology, Dongnam Institute of Radiological and Medical Sciences, Busan 46033, Korea
3Animal and Plant Quarantine and Inspection Agency (QIA), Gyeongsangbuk-do 39660, Korea
4Department of Clinical Laboratory Science, Chungbuk Health and Science University, Chungbuk 28150, Korea
Correspondence to: Kyung-Soo Chang. Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Korea.
Tel: +82-51-510-0565, Fax: +82-51-510-0568, e-mail: kschang@cup.ac.kr
*Graduate student, **Researcher, ***Professor.
Received June 14, 2018; Accepted August 23, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Cryptococcosis, which is caused by the Cryptococcus species complex (including Cryptococcus neoformans and Cryptococcus gattii), is well known as one of the most important medical problems. However, the of the Cryptococcus species complex is still limited to pneumonia and meningitis. In particular, the differences in virulence among the five major serotypes of the Cryptococcus species complex are not fully understood. To elucidate the virulence of the Cryptococcus species complex when it is disseminated hematogenously, rats were infected by different strains of the Cryptococcus species serotype, and their histopathological characteristics were compared after infection. The cumulative mortality ratio of rats infected with serotype B strain was slightly higher than in the other experimental groups. In addition, the average recovery of the Cryptococcus species complex from rats infected with serotype B strain was significantly higher than in the other groups in almost all organ samples except spleen. The recovery of the Cryptococcus species complex was associated with the severity of histopathological lesions, including bleeding, inflammation, and tissue damage in all organs. In rats infected with serotype B strain, the virulence was the most severe, especially in the lungs and liver. These results indicate that the pathophysiology of the Cryptococcus species complex infection differs according to serotype.
Keywords : Cryptococcus species complex, Serotype, Virulence, Histopathological change, Rat model