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Growth Inhibitory Effects of Chlorine Dioxide on Bacteria
Biomed. Sci. Lett. 2018;24:270-274
Published online September 30, 2018;
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Kyoung-Ju Song1,* and Suk-Yul Jung2,†,**

1Purgofarm Co. Ltd, Hwasung-city, Gyeonggi 18627, Korea
2Department of Biomedical Laboratory Science, Molecular Diagnosis Research Institute, Namseoul University, Chungnam 31020, Korea
Correspondence to: Suk-Yul Jung. Department of Biomedical Laboratory Science, Molecular Diagnosis Research Institute, Namseoul University, 91 Daehak-ro, Seonghwan-eup, Seobuk-gu, Cheonan-city, Choongnam 31020, Korea.
Tel: +82-41-580-2723, Fax: +82-41-580-2932, e-mail:
*Chief Technology Officer, **Professor.
Received August 7, 2018; Revised August 17, 2018; Accepted August 23, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Chlorine dioxide (ClO2) gas is a neutral chlorine compound. ClO2 gas was proven to effectively decontaminate different environments, such as hospital rooms, ambulances, biosafety level 3 laboratories, and cafeterias. In this study, to evaluate the effects of ClO2 gas, bacteria of clinical importance were applied. Staphylococci, Streptococci and Bacillus strains were applied and Klebsiella, and others e.g., Escherichia coli, Shigella, Salmonella, Serratia were also done for the inhibitory analysis. Bacteria plates were applied with a hygiene stick, namely, "FarmeTok (Medistick/Puristic)" to produce ClO2. ClO2-releasing hygiene stick showed the very strong inhibition of bacterial growth but had different inhibitions to the bacteria above 96.7% except for MRSA of 90% inhibition. It is difficult to explain why the MRSA were not inhibited less than others at this point. It can be only suggested that more releasing ClO2 should be essential to kill or inhibit the MRSA. B. subtilis, S. agalactiae, S. pyogenes, E. coli O157:H7, S. typhi (S. enterica serotype typhi) and S. marcesence were inhibited over 99%. This study will provide fundamental data to research growth inhibition by ClO2 gas with bacteria of clinical importance value.
Keywords : Chlorine dioxide, Bacteria, Inhibition, FarmeTok (Medistick/Puristic)