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Beyond X-Chromosome Inactivation: The Oncogenic Facet of XIST in Human Cancers
Biomed Sci Letters 2019;25:113-122
Published online June 30, 2019;  https://doi.org/10.15616/BSL.2019.25.2.113
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Hamadi Madhi* and Myoung Hee Kim,**

Department of Anatomy, Embryology Laboratory, and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea
Correspondence to: Myoung Hee Kim. Department of Anatomy, Embryology Laboratory, and Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul 03722, Korea.
Tel: +82-2-2228-1647, Fax: +82-2-365-0700, e-mail: mhkim1@yuhs.ac
Received March 8, 2019; Accepted June 14, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Long-non coding RNAs (LncRNAs) constitute a wide and extremely diverse family of RNA transcripts that are greater than 200 base pairs in length and are not translated into proteins. X-inactive specific transcript (XIST) was the first long non-coding RNA to be discovered, back in 1991. Its function in X-chromosome inactivation has been extensively studied for three decades, though other functional roles of XIST that involve a variety of fascinating mechanisms remain to be elucidated. Here, we review the emerging oncogenic role of XIST in various human cancers.
Keywords : X chromosome inactivation, XIST, LncRNA, CeRNA, Human cancer; miRNA