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The Genetic Variations of NOD2 Are Associated With White Blood Cell Counts
Biomed Sci Letters 2018;24:334-340
Published online December 31, 2018;  https://doi.org/10.15616/BSL.2018.24.4.334
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Hyun-Seok Jin1,2* and Sangwook Park3,†,*

1Department of Biomedical Laboratory Science, College of Life and Health Sciences, Hoseo University, Asan, Chungnam 31499, Korea
2The Research Institute for Basic Science, Hoseo University, Asan, Chungnam 31499, Korea
3Department of Biomedical Laboratory Science, College of Health and Nurse, Kyungwoon University, Gumi 39160, Korea
Correspondence to: *Professor.
Sangwook Park. Department of Biomedical Laboratory Science, College of Health and Nurse, Kyungwoon University, Gumi 39160, Korea.
Tel: +82-54-479-1282, Fax: +82-54-479-1280, e-mail: spark367@ikw.ac.kr
Received August 17, 2018; Revised September 19, 2018; Accepted October 8, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
The cytoplasmic elicitor, nucleotide-binding domain and leucine-rich repeat containing domain receptors (NLRs) is well established molecules in its role in inflammatory response. Among 22 NLR receptors, NOD2 is one of the intensively studied genes of elucidating for the inflammatory bowel disease and Crohn's disease as well. Recent research have accumulated that common genetic mutations in Parkinson's disease (PD) are increasingly related to the susceptibility to Crohn's disease. In this study, with the Korean Genome and Epidemiology Study, we aimed to perform the association between NOD2 polymorphisms and blood cell counts [WBC (white blood cell) count, RBC (red blood cell) count, platelet count], which linked supposedly to cytoplasmic inflammatory responses with clinical specialty. Linear regression analyses were performed, controlling for residential area, sex, and age as covariates. As a results, 12 SNPs from NOD2 gene were significantly associated with WBC counts (Bonferroni correction P-value criteria 竊 0.05/23=0.00218). In this study, we could ensure an association with NOD2 gene and WBC counts. This is the first report to have relationship between SNPs of NOD2 gene and WBC counts.
Keywords : Nucleotide-binding, Oligomerization domain-containing 2 (NOD2), White Blood cell (WBC), Association, Single Nucleotide Polymorphism (SNP)