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The Inhibitory Effect of Gooseberry on DNCB-induced Atopic Dermatitis in vivo and in vitro
Biomed Sci Letters 2018;24:349-356
Published online December 31, 2018;  https://doi.org/10.15616/BSL.2018.24.4.349
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Su-Jin Kim†,*

Department of Biotechnology and Convergence, Daegu Haany University, Kyungsan 38578, Korea
Correspondence to: *Professor.
Su-Jin Kim. Department of Biotechnology and Convergence, Daegu Hanny University, Kyungsan 38578, Korea.
Tel: +82-53-819-1389, Fax: +82-53-819-1389, e-mail: ksj1009@dhu.ac.kr
Received November 9, 2018; Revised December 12, 2018; Accepted December 17, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Generally, berry fruits have various pharmacological activities such as anti-inflammation, anti-oxidation and anti-cancer effects. The effects of gooseberry, a berry fruits, on atopic dermatitis (AD) have not been widely examined. The aim of this present study is to investigate whether gooseberry modulates AD. We examined the pharmacological effects of gooseberry on 2, 4-dinitrochlorobenzene (DNCB)-induced AD symptoms in mice. To determine the anti-atopic mechanism of gooseberry, we investigated its effects on the production of inflammatory cytokines and activation of nuclear factor-κB in PMA + ionophore -stimulated human mast cells (HMC-1). The results demonstrated that gooseberry attenuated AD clinical symptoms such as erythema, edema and dryness as well as histamine and IgE serum levels in DNCB-induced AD model mice. Additionally, gooseberry suppressed the expression of inflammatory cytokines and activation of nuclear factor-κB in stimulated HMC-1. These findings demonstrate that gooseberry is potential agent for treating AD and allergic inflammation.
Keywords : Gooseberry, Atopic dermatitis, Inflammatory cytokines, Nuclear factor-κB