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Herbal Black Vinegar and the Anti-obesity Complications in vivo
Biomed Sci Letters 2018;24:380-389
Published online December 31, 2018;  https://doi.org/10.15616/BSL.2018.24.4.380
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Dongsub Lee1,* and Sangwook Park2,†,*

1Department of Healthcare & Biotechnology, College of Aeroservice, Kyungwoon University, Gumi 39160, Korea
2Department of Biomedical Laboratory Science, College of Health and Nurse, Kyungwoon University, Gumi 39160, Korea
Correspondence to: *Professor.
Sangwook Park. Department of Biomedical Laboratory Science, College of Health and Nurse, Kyungwoon University, Gumi 39160, Korea.
Tel: +82-54-479-1282, Fax: +82-54-479-1280, e-mail: spark367@ikw.ac.kr
Received September 17, 2018; Revised November 21, 2018; Accepted December 10, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Black vinegar has been traditionally used for supplemental flavoring on food, and commercialized beverages. Here, to investigate the effects on in vivo anti-obesity complications of black vinegar produced with herbal extracts, we evaluated on the biochemical effects of high-fat diet (HFD) induced mice compared to control fed ones. After a 84-day experiment HFD mice had higher (P 竊 0.05) weight gains, relative abdominal-fat pads, blood glucose level, serum/liver lipids, and serum nephron indices. Continuous oral treatment of three different concentration of herbal black vinegar (HBV; stock, 2-fold, and 4-fold diluted solution) to HFD mice showed that HBV reduced marked obesity (fat depositions, adipocyte hypertrophy), hyperglycemia, hyperlipidemia (serum total cholesterol, triglyceride, LDL- cholesterol levels), enhanced liver function (AST/ALT), and kidney function (BUN, creatine levels), respectively. Thus, HBV is expected to serve as an efficient and functional supplemental ingredients or food for the alleviation of obesity syndrome.
Keywords : HBV (Herbal black vinegar), Anti-obesity, High-fat diet (HFD)