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The Comparison of Risk Factors for Ischemic Stroke or Intracranial Hemorrhage in Korean Stroke Patients: A Nationwide Population-based Study
Biomed Sci Letters 2018;24:405-410
Published online December 31, 2018;
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Sun-Young Choi1,*, Ji-In Kim2,†,* and Shin-Woo Hwang2,*

1Department of Biomedical Laboratory Science and 2Nursing, Daegu Health College, Daegu, 41453 Korea
Correspondence to: *Professor.
Ji-In Kim. Department of Nursing, Daegu Health College, Youngsong-ro, Buc-gu, Daegu 41453, Korea.
Tel: +82-53-320-1462, Fax: +82-53-320-1450, e-mail:
Received November 16, 2018; Revised November 24, 2018; Accepted November 27, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Stroke is a leading cause of death in the Korean population and remains a major health burden worldwide. The two main pathologic types of stroke are ischemic stroke and intracranial hemorrhage (ICH), but comparisons of risk factors for these have been limited. We under took a nationwide population-based study to analyze the relationship between these risk factor sand ischemic stroke and ICH. From January 2003 to December 2013, a total of 37,561 patients with newly diagnosed ischemic stroke or ICH were identified using the National Health Insurance Service data base as the study population. Multivariable logistic regression analysis was used to determine the association between baseline risk factors and presentation with ICH versus ischemic stroke. The incidence of ischemic stroke showed an increasing rend every year, while there was no significant change in the incidence of ICH. Of the several risk factors associated with stroke, old age (OR 2.35, 95% CI 2.12~2.49, P 竊 0.001) was more closely associated with ischemic stroke than ICH, whereas renal disease (OR 0.74, 95% CI 0.55~0.99, P = 0.04) and carotid disease (OR 0.25, 95% CI 0.17~0.35, P 竊 0.001) were more strongly associated with ICH. In addition, diabetes mellitus, dyslipidemia, hypertension, ischemic heart disease and male sex was associated with an increased risk of ischemic stroke. Old age was more strongly associated with ischemic stroke than ICH, while carotid stenosis and renal impairment were more closely associated with ICH risk. Classic risk factors for stroke have considerably different associations with the two main pathologic types of stroke.
Keywords : Stroke, Intracranial hemorrhage, Risk factor