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Effect of Extreme Long-Distance Running on Hepatic Metabolism and Renal Function in Middle-Aged Men
Biomed Sci Letters 2018;24:411-417
Published online December 31, 2018;
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Kyung-A Shin1,* and Young-Joo Kim2,†,*

1Department of Clinical Laboratory Science, Shinsung University, Chungnam 31801, Korea
2Department of Exercise Rehabilitaion Welfare, Sungshin University, Seoul 02844, Korea
Correspondence to: *Professor.
Young-Joo Kim. Department of Exercise Rehabilitaion Welfare Soojung Campus, Sungshin University, 2 Bomun-Ro 34Da-Gil, Seongbuk-Gu, Seoul 02844, Korea.
Tel: +82-2-920-7942, Fax: +82-2-920-7942, e-mail:
Received October 1, 2018; Revised November 12, 2018; Accepted November 13, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
The aim of this study was to investigate the impact of participation in the 622 km hyper-ultra-marathon on hepatic metabolism and renal function in middle-aged men. Healthy middle-aged male amateur ultra-marathoners between the ages of 40 and 60. Blood was collected at the pre-race, immediately after 300 km, 622 km hyper-ultra marathon race, 72 hours (3 day) and 144 hours (6 day) after the race, AST (aspartate aminotransferase), ALT (alanine aminotransferase), ALP (alkaline phosphatase), γ-GTP (gamma glutamyl transferase), T-Bil (total bilirubin), D-Bil (direct bilirubin), T-protein (total protein), albumin, uric acid, BUN (blood urea nitrogen), creatinne were analyzed. ALP was significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race. γ-GTP, T-protein, albumin, uric acid, BUN and creatinine were not significantly different between the distances and the recovery period respectively. AST and ALT were significantly increased at 300 km, 622 km, day 3 and day 6 than the pre-race, respectively (P竊0.05) at day 3 and day 6 they showed significant decrease from 300 km and 622 km, respectively (P竊0.05). T-Bil and D-Bil increased significantly at 300 km and 622 km, respectively (P竊.05) and significantly decreased at day 3 (P竊0.05) compared to the pre-race, at day 3 and day 6 they were decreased significantly than 300 km and 622 km, respectively (P竊0.05). In conclusion, no disturbance of renal function was observed according to the distances and between the recovery period of 622 km hyper-ultra marathon race, but reversible hepatocyte function could be degraded and some hemolysis of blood vessels was induced.
Keywords : Ultra-marathon, Hepatic metabolism, Renal function