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Effect of Natural Compounds on Catechol Estrogen-Induced Carcinogenesis
Biomed Sci Letters 2019;25:1-6
Published online March 31, 2019;  https://doi.org/10.15616/BSL.2019.25.1.1
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Nam-Ji Sung*, and Sin-Aye Park,**

Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea
Correspondence to: Sin-Aye Park. Department of Biomedical Laboratory Science, College of Medical Sciences, Soonchunhyang University, Asan 31538, Korea.
Tel: +82-41-530-4990, Fax: +82-41-530-3085, e-mail: sappark@sch.ac.kr
Received January 28, 2019; Revised March 25, 2019; Accepted March 25, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
The hydroxylation of estradiol results in the formation of catechol estrogens such as 2-hydroxyestradiol (2-OHE2) and 4-hydroxyestradiol (4-OHE2). These catechol estrogens are further oxidized to quinone metabolites by peroxidases or cytochrome P450 (CYP450) enzymes. Catechol estrogens contribute to hormone-induced carcinogenesis by generating DNA adducts or reactive oxygen species (ROS). Interestingly, many of the natural products found in living organisms have been reported to show protective effects against carcinogenesis induced by catechol estrogens. Although some compounds have been reported to increase the activity of catechol estrogens via oxidation to quinone metabolites, many natural products decreased the activity of catechol estrogens by inhibiting DNA adduct formation, ROS production, or oxidative cell damage. Here we focus specifically on the chemopreventive effects of these natural compounds against carcinogenesis induced by catechol estrogens.
Keywords : Catechol estrogen, 4-Hydroxyestradiol, Carcinogenesis, Natural compounds, Cancer prevention