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A Comparative Study of [F-18] Florbetaben (FBB) PET Imaging, Pathology, and Cognition between Normal and Alzheimer Transgenic Mice
Biomed Sci Letters 2019;25:7-14
Published online March 31, 2019;  https://doi.org/10.15616/BSL.2019.25.1.14
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Ngeemasara Thapa1,* , Young-Jin Jeong2,3,*** , Hyeon Kang3,* , Go-Eun Choi4,*** , Hyun-Jin Yoon2,3,** and Do-Young Kang2,3,,***

1Department of Health care and Science, College of Health Sciences, Dong-A University, Busan 49315, Korea 2Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, Busan 49201, Korea 3Institute of Convergence Bio-Health, Dong-A University, Busan 49315, Korea 4Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan, Busan 46252, Korea
Correspondence to: Do-Young Kang. Department of Nuclear Medicine, Dong-A University Medical Center, Dong-A University College of Medicine, #26 Daesingongwon-ro, Seo-gu, Busan 49201, Korea
Tel: +82-51-240-5630, Fax: +82-51-242-7237, e-mail: dykang@dau.ac.kr
Received February 8, 2019; Accepted March 5, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Alzheimer's disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer's disease-like pathology have been widely used to study the pathophysiology of Alzheimer's disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with controls) were used for this study. We observed an increase in 棺-Amyloid deposition (A棺) in brain tissue and [F-18] FBB amyloid PET imaging in the AD group. The [F-18] FBB data showed a mildly negative trend with cognitive function. Pathological findings were negatively correlated with cognitive functions. These finding suggests that amyloid beta deposition can be well-monitored with [F-18] FBB PET and a decline in cognitive function is related to the increase in amyloid plaque burden.
Keywords : [F-18] FBB, Tg2576 mouse, Alzheimer's disease, 棺-Amyloid, PET imaging