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Anti-inflammatory Modulating Effect of Rengyolone in Rat
Biomed Sci Letters 2019;25:54-59
Published online March 31, 2019;  https://doi.org/10.15616/BSL.2019.25.1.54
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Gil-Hyon Lee1,* , Kyung-Yae Hyun3,* and Yoon-Jung Kang2,,*

1Department of Clinical Laboratory Science, Dong-seo University, Busan 47011, Korea 2Department of Clinical Laboratory Science, Sang-ji University, Wonju 26339, Korea 3Department of Clinical Laboratory Science, Dong-eui University, Busan 47340, Korea
Correspondence to: Yoon-Jung Kang. Department of Clinical Laboratory Science, Sang-ji University, 83 Sangjidaegil, Seo-gu, Wonju 26339, Korea.
Tel: +82-33-738-8081, Fax: +82-33-730-0114, e-mail: lvpig@naver.com
Received February 26, 2019; Revised March 26, 2019; Accepted March 27, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Hepatitis refers to inflammation of hepatocytes and liver tissue, and is mainly caused by viruses, alcohol, and drugs. Forsythiae Fructus has traditionally been used as a diuretic, anti-inflammatory and antipyretic. Research on rengyolone, a bioactive substance extracted from Forsythiae Fructus, is rarely found in Korea and abroad. First, an acute animal toxicity test for rengyolone was conducted for the animal experiment. 4 week-old SD rats were injected intraperitoneally with acetaminophen for 2 weeks to induce chronic liver inflammation. Rengyolone was orally administered into two groups during 4 weeks: pre-inflammatory group and post-inflammatory group. Oral doses were also divided into 1 mg/kg and 5 mg/kg. Liver function tests (ALT, AST, ALP), western blot analysis of liver tissue, and level of inflammatory cytokine were performed to evaluate the improvement of hepatitis. Experimental results showed that rengyolone inhibited the development of acute inflammation and thus could reduce hepatitis symptoms.
Keywords : Hepatitis, Forsythiae fructus, Rengyolone, Acetaminophen, Liver function tests, iNOS