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The Ameliorative Effect of Angelica acutiloba Ameliorates Through the NO / iNOS Pathway in Rats with Systemic Allergy
Biomed Sci Letters 2019;25:83-91
Published online March 31, 2019;  https://doi.org/10.15616/BSL.2019.25.1.83
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Min-Seok Cho1,*, Hae-Woong Park1,*, Gil-Hyun Lee2,**, Hae-Gyung Yoon3,**, Kyung-Mo Oh4,**, Seok-Cheol Choi1,** and Kyung-Yae Hyun2,,**

1Department of Clinical Laboratory Science, Catholic University of Pusan, Busan 4625, Korea 2Department of Clinical Laboratory Science, Dong-Eui University, Busan 47340, Korea 3Division of Basic Sciences, Dong-eui University, Busan 47340, Korea 4Department of Sports Leisure, Busan Kyungsang College, Busan 47583, Korea
Correspondence to: Kyung-Yae Hyun. Department of Clinical Laboratory Science, Dong-Eui University, Busan 47340, Korea.
Tel: +82-51-890-2683, Fax: +82-51-890-2622, e-mail: kyhyun@deu.ac.kr
Received February 28, 2019; Revised March 15, 2019; Accepted March 18, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
This study was undertaken to investigate the therapeutic effect of Angelica acutiloba on allergic dermatitis, which Angelica acutiloba is traditionally known to have antiinflammatory effects. Sprague-Dawley (SD) rats were divided into five groups: normal control group, experimental allergic dermatitis group (vehicle group), low dose of Angelica acutiloba extract (low-dose group), high dose of Angelica acutiloba extract (high-dose group), and antihistamine treated group with experimental dermatitis (antihistamine group). Total leukocyte, neutrophil, lymphocyte, monocyte and eosinophil counts were significantly higher in the vehicle group than in the control group, but these variables were significantly lower in the low- and high-dose groups than in the vehicle group. The platelet/lymphocyte ratio in the red blood cell index was significantly lower in the low- and high-dose groups than in the vehicle group. Low and high doses of the Angelica acutiloba extract did not have toxic effects on liver and kidney. Serum NO, iNOS and levels were highest in the vehicle group but significantly lower in the low- and high-dose groups, especially in the high-dose group. The results of this study suggested that the Angelica acutiloba extract had the effect of alleviating or treating the experimental allergic dermatitis, and it was concluded that the high dose was more effective.
Keywords : Experimental allergic dermatitis, Angelica acutiloba, Total white blood cell, NO, iNOS