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Comparison of the Antioxidant Activities of Various Processed Fruits and Vegetables in APAP-induced Oxidative Stress in BALB/c Mice
Biomed Sci Letters 2019;25:211-217
Published online September 30, 2019;
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Evelyn Saba1,*, Yuan Yee Lee1,*, Minki Kim1,*, Hyun-Kyoung Kim2,** and Man Hee Rhee1,,**

1Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea
2Department of Food Science and Engineering, Seowon University, Chungbuk 28674, Korea
Correspondence to: Man Hee Rhee. Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Korea.
Tel: +82-53-950-5967, Fax: +82-53-950-5955, e-mail:
*Graduate student, **Professor.
Received June 7, 2019; Revised June 24, 2019; Accepted July 4, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research has established a strong connection between a diet rich in antioxidants and a decreased incidence of cardiovascular disease and cancer. These diets prominently feature fruits and vegetables containing high amounts of vitamins A, B, C and E, carotenoids, and minerals. Different processing conditions for these foods can alter their nutrient complement and potency. This study compared the antioxidant properties of a range of processed fruits and vegetables to see which yielded the highest level of antioxidant activity. We used an acetaminophen-induced oxidative stress mouse model to evaluate the antioxidant effects of extracts of processed apple, pear, carrot, cabbage, broccoli, and radish. Our results showed that the administration of these fruits decreased the expression of oxidative stress indicators such as ALT, AST, catalase, superoxide dismutase, GPx, and 8-OHdG. They also significantly protected mice livers from APAP-induced damage, as shown by histological evaluation. Our results have demonstrated the positive effects of processed fruits and vegetables in a mouse model of oxidative stress.
Keywords : Antioxidant activity, Vegetables, Fruits, Acetaminophen, Mice