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Modulation Effects on Acute Orofacial Inflammatory Pain in Rats by Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc. Extracts
Biomed Sci Letters 2019;25:247-255
Published online September 30, 2019;
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Hee-Jin Kim*, Ja-Hyung Choi*, Hye-Jin Kim**, Hyun-Soe Yoon** and Min-Kyung Lee,**

Department of Biomedical Health Science, Dong-eui University, Busan 47340, Korea
Correspondence to: Min-Kyung Lee. Department of Biomedical Health Science, Dong-eui University, 176 Eongwangno(gayadong san24), Busanjin-gu, Busan 47340, Korea.
Tel: +82-51-890-4238, Fax: +82-0505-182-6878, e-mail:
*Graduate student, **Professor.
Received August 5, 2019; Revised September 10, 2019; Accepted September 16, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Curcuma longa L. (C.L), Curcuma aromatica Salisb. (C.A) and Zingiber officinale Rosc. (Z.O) of Zingiberaceae plants which are well known as effects of natural anti-oxidant, anti-cancer and anti-inflammatory. We examined that the Zingiberaceae plants are involved in development and modulation of orofacial pain in rats. Male, 7- to 8-week-old, Sprague-Dawley rats weighing 240~280 g were used in this study. Experiments were performed using acute pain model that was caused by the injection of 5% formalin into the right vibrissa pad. The number of scratching or rubbing to the injection site was recorded for 9 consecutive 5-minute intervals following injection of formalin. The experimental groups were acute orofacial inflammatory pain; control group (formalin, 5%), vehicle group (5% formalin after sodium carboxymethyl cellulose), single administration group, single mixed administration group, repeated administration group. The experiments were performed various concentrations of Zingiberaceae plants extract. Therefore, oral administration of C.L, C.A, and Z.O (p.o., concentrations of 12.5, 25 mg/mL) in orofacial inflammatory pain model substantially decrease the nociceptive behavior in a concentration dependent manner. And it tended to decrease at low concentration (12.5 mg/mL) of single mixed and repeated administration more than single administration. This result means that Zingiberaceae plants extract affects the modulation of acute orofacial inflammatory pain. Thus, Zingiberaceae plants extract may be a potential therapeutic treatment for orofacial inflammatory pain.
Keywords : Curcuma longa L., Curcuma aromatica Salisb., Zingiber officinale Rosc., Inflammatory, Orofacial pain