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Dehydrocostus Lactone Suppresses the Expression of iNOS Induced by TLR Agonists
Biomed Sci Letters 2019;25:267-274
Published online September 30, 2019;  https://doi.org/10.15616/BSL.2019.25.3.267
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Su Yeon Kim*, Sunghye Heo*, Seung Han Kim*, Minji Kwon*, Sin-Aye Park** and Hyung-Sun Youn,**

Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 31538, Korea
Correspondence to: Hyung-Sun Youn. Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Soonchunhyang-Ro 22, Shinchang-Myun, Asan-Si, Chungnam 31538, Korea.
Tel: +82-41-530-3086, Fax: +82-41-530-3085, e-mail: hyoun@sch.ac.kr
*Ungraduate student, **Professor.
Received July 4, 2019; Revised August 8, 2019; Accepted August 17, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Toll-like receptors (TLRs) are one of the families of pattern recognition receptors (PRR) to recognize pathogen-associated molecular patterns (PAMPs). PAMPs stimulate TLRs to initiate specific immunoactivity. The activation of TLRs signaling leads to the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of dehydrocostus lactone (DHL), which is a natural sesquiterpene lactone derived from various medicinal plants, iNOS expression induced by LPS (TLR4 agonist), MALP-2 (TLR2 and TLR6 agonist), or Poly[I:C] (TLR3 agonist) were examined. DHL suppressed the iNOS expression induced by LPS, MALP-2, or Poly[I:C]. DHL also inhibited nitrite production induced by LPS, MALP-2, or Poly[I:C]. These results suggest that DHL can modulate TLRs signaling pathways resulting in anti-inflammatory effect.
Keywords : Dehydrocostus lactone; Inducible nitric oxide synthase; TLR; Inflammation; LPS