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Effect of Euterpe oleracea Mart. (acai berry) Extract on Skin Flap Survival in Mice
Biomed Sci Letters 2019;25:282-287
Published online September 30, 2019;  https://doi.org/10.15616/BSL.2019.25.3.282
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Sangbong Jung1,**, Jongsik Kim2,*, Eun-Joong Kim3,** and Ki-Jong Rhee4,,**

1Department of Medical Laboratory Science, Dongeui Institute of Technology, Busan 47230, Korea
2Department of Anatomy, College of Medicine, Kosin University, Busan 49104, Korea
3Department of Clinical Laboratory Science, Chungbuk Health and Science University, Cheongju 28150, Korea
4Department of Biomedical Laboratory Science, Yonsei University MIRAE Campus, Wonju 26493, Korea
Correspondence to: Ki-Jong Rhee. Department of Biomedical Laboratory Science, Yonsei University Mirae Campus, 1 Yonseidae-gil, Mirae Hall, RM 208, Wonju, Gangwon-do 26493, Korea.
Tel: +82-33-760-2445, Fax: +82-33-760-2561, e-mail: kjrhee@yonsei.ac.kr
*Researcher, **Professor.
Received August 5, 2019; Revised September 14, 2019; Accepted September 16, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Skin flap necrosis remains a major complication of reconstructive surgery. Euterpe oleracea Mart., popularly known as "acai berry" contains hydroxybenzoic acid, antioxidant polyphenolics and anthocyanins. These and other compounds within the acai berry confer anti-inflammatory and anti-oxidative effects. In this current study, we evaluated the protective effect of acai berry extracts on survival of random-pattern skin flaps in a murine model by histologic analysis. ICR mice were subjected to skin elevation surgery and orally administered acai berry extract (100 mg/kg) daily for 7 days. Tissues were stained with hematoxylin-eosin or Masson's trichrome to observe tissue integrity and collagen deposition. In addition, TGF-棺 and VEGF was stained by immunofluorescence to determine anti-inflammatory cell infiltration and neovascularization, respectively. We found a decrease in inflammatory cell infiltration and increase in collagen deposition in the acai berry extract treated mice compared to control mice. Immunofluorescence staining reveal a higher number of TGF-棺 positive cells and enhanced VEGF staining in the acai berry extract treated mice. The results from this study indicate that oral uptake of acai berry extract can promote healing and survival of surgical skin flaps in mice providing an augmentative therapeutic approach to enhancing skin flap survival.
Keywords : Skin flap, Euterpe oleracea Mart., Acai berry, Inflammation