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Antimicrobial Activities of Extracts of Camellia sinensis (L.) O. Kuntze and Profile of Antimicrobial Agents Resistance for Carbapenem-Resistant Enterobacteriaceae
Biomed Sci Letters 2019;25:288-292
Published online September 30, 2019;  https://doi.org/10.15616/BSL.2019.25.3.288
© 2019 The Korean Society For Biomedical Laboratory Sciences.

Jong Hwa Yum†,*

Department of Clinical Laboratory Science, Dongeui University, Busan 47340, Korea
Correspondence to: †Jong Hwa Yum. Department of Clinical Laboratory Science, Dongeui University, Busan 47340, Korea.
Tel: +82-51-890-2682, Fax: +82-505-182-6877, e-mail: auxotype@deu.ac.kr
*Professor.
Received August 20, 2019; Revised September 2, 2019; Accepted September 9, 2019.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
In vitro antimicrobial activities of hot water extracts of Camellia sinensis (L.) O. Kuntze, for carbapenem-resistant Enterobacteriaceae (CRE) were compared to commonly used conventional antimicrobial agents. CRE was not only resistant to imipenem, meropenem or ertapenem, but also to various antimicrobial agents, such as amikacin (> 128 µg/mL). The hot water extracts of Camellia sinensis (L.) O. Kuntze had the lowest MIC (0.06~0.5 µL/mL) of the carbapenem-resistant E. coli, K. pneumoniae, and Enterobacter spp. tested, and it was possible more potent than various conventional antimicrobial agents. Synergistic combinations of the extract with used commonly antimicrobial agents might even improve its antimicrobial chemotherapy property.
Keywords : Camellia sinensis (L.) O. Kuntze, Enterobacteriaceae, Carbepenem resistant, Catechin, Antimicrobial agent