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Effects of Natural Products on Acute Orofacial Pain Control Enhanced by Oral Disease
Biomed Sci Letters 2020;26:327-335
Published online December 31, 2020;  https://doi.org/10.15616/BSL.2020.26.4.327
© 2020 The Korean Society For Biomedical Laboratory Sciences.

Ja-Hyeong Choi1,,* and Min-Kyung Lee2,3,*

1Department of Dental Hygiene, Kyung-Woon University, Gumi 39160, Korea
2Department of Dental Hygiene, Dong-Eui University, Busan 47340, Korea
3The Research Institute Health for Functional Material, Busan 47340, Korea
Correspondence to: Ja-Hyeong Choi. Department of Dental Hygiene, Kyung-Woon University, 730, Gangdong-ro, Sandong-myeon, Gumi-si, Gyeongsangbuk-do 39160, Korea.
Tel: +82-54-479-4066, Fax: +82-54-479-4119, e-mail: ng486c@hanmail.net
*Professor.
Received November 16, 2020; Revised December 8, 2020; Accepted December 10, 2020.
 Abstract
As the interest in oral health is increasing with quality of life. The most representative oral diseases include dental caries, periodontal disease, and malocclusion, as well as dry mouth and oral mucosa. Cinnamaldehyde have an antioxidant effect that has been studied not only to treat rheumatism and hypertension, but also to protect liver, and gastrointestinal tract, but there are few studies related to the control of oral diseases. The purpose of this study was the effect of enhanced orofacial pain when oral administration of cinnamaldehyde in the oral diseases. Cinnamaldehyde (5, 12.5, 25, and 50 mg/ kg) orally administered at a dose of 1 mL, and the change in biological response was confirmed after a week. In addition, 5% formalin (30, 50 關L) was injected into TMJ and subcutaneous areas of the whiskers of rats to observe the change in the threshold of the improved orofacial pain model. As a result of the experiment, in the xerostomia model, drinking water was decreased in the cinnamaldehyde-administered group, feed intake and weight increased, and saliva was also increased compared to the naïve group. In particular, the most significant increase trend was observed at the concentrations of 25 and 50 mg/kg. In addition, it was confirmed that the pain behavioral response of the orofacial area improved by oral diseases decreased depending on the concentration of cinnamaldehyde. Based on these results, cinnamaldehyde effectively reduced symptoms related to xerostomia and showed improved pain relief in the orofacial areas.
Keywords : Oral disease, Cinnamaldehyde, Submandibular gland, Orofacial pain
꽌 濡

怨쇨굅뿉 鍮꾪븯뿬 寃쎌젣 꽦옣쓽 諛쒕떖濡 씤븳 쁺뼇긽깭쓽 媛쒖꽑쑝濡 떊泥댁쓽 꽦옣 諛쒕떖씠 媛쒖꽑릺뿀쑝굹 떦吏덉쓽 븿웾씠 넂 媛怨듭떇뭹쓽 臾대텇蹂꾪븳 옦 꽠痍 벑쓽 떇깮솢쓽 蹂솕濡 援ш컯嫄닿컯긽깭媛 젏젏 븙솕릺怨 엳뒗 떎젙씠떎(Song and Moon, 2002). 援ш컯吏덊솚 쁽옱 꽭怨꾩뿉꽌 쓷엳 諛쒖깮릺뒗 嫄닿컯 臾몄젣 以 븯굹濡(Myburgh et al., 2004) 援ш컯嫄닿컯긽깭 궣쓽 吏덇낵쓽 愿젴꽦씠 엯利앸릺硫댁꽌 궣쓽 吏덉쓽 留뚯”룄 긽듅 슂씤뿉 엳뼱 援ш컯 嫄닿컯뿉 愿븳 愿떖씠 利앸릺怨 엳떎(Mari챰o et al., 2008). 媛옣 몴쟻씤 援ш컯吏덊솚쑝濡쒕뒗 移섏븘슦떇利, 移섏<蹂, 遺젙援먰빀쓣 샇냼븯뒗 寃쎌슦媛 留롮쑝硫 洹 쇅뿉 援ш컯嫄댁“利, 援ш컯젏留됱쭏솚 벑씠 엳떎. 洹 以 援ш컯嫄댁“利앹 뿬윭 援ш컯 湲곕뒫뿉 쁺뼢쓣 誘몄튂硫 遺덊렪媛, 넻利 벑쑝濡 媛쒖씤쓽 궣쓽 吏덉쓣 븯떆궎뒗 吏덊솚쑝濡 븸 쓲由꾩쓽 媛먯냼 삉뒗 븸 遺꾨퉬 븯瑜 넻븯뿬 異⑹튂, 援ш컯 蹂묐, 移섏<뿼, 誘멸컖쓽 蹂솕, 젏븸꽦 븸 遺꾨퉬, 옉媛, 移⑥깦 媛먯뿼, 吏꾧퇏 媛먯뿼 벑怨 媛숈 寃곌낵濡 굹궇 닔 엳떎(Atkinson et al., 2005). 援ш컯嫄댁“利앹 떎뼇븳 빟臾 諛 깮臾쇳븰쟻씤 슂씤 諛 뒪듃젅뒪, 遺덉븞媛, 슦슱利앷낵 媛숈 떖由ъ쟻씤 슂씤씠 썝씤쑝濡 蹂 닔 엳뒗뜲, 깮由ъ쟻 슂씤쑝濡 꽭룷 닔 媛먯냼 諛 꽭룷 湲곕뒫 븯, 洹쇱쑁 湲곕뒫 媛먯냼 媛숈 끂솕濡 씤븳 눜뻾꽦 蹂솕 벑쑝濡 옄쑉떊寃쎄퀎 湲곕뒫씠 븯맂떎(Yasuko et al., 1998). 삉븳 끂졊솕 궗쉶濡 룊洹 닔紐낆씠 뿰옣릺뼱 쟾떊吏덊솚 씤援 利앷 뜑遺덉뼱 옣湲곌컙 빟臾 蹂듭슜 湲곌컙怨 愿젴릺뼱 엳떎. 븣痢좏븯씠癒몃퀝 諛 뙆궓뒯 吏덊솚, 궪솚怨 빆슦슱젣, 怨좏삁븬젣옱쓽 蹂듭슜 벑쓽 쟾떊吏덊솚뿉 쓽븳 빟臾 蹂듭슜쓣 鍮꾨’븯뿬, 몢寃쎈 븫 移섎즺 諛⑸쾿씤 諛⑹궗꽑슂踰뺤쑝濡쒕룄 븸꽑 넀긽뿉 쁺뼢쓣 誘몄튇떎(Yair et al., 2015). 븘듃濡쒗, 湲由ъ퐫뵾濡ㅻ젅씠듃 벑怨 媛숈 빆肄쒕┛젣뒗 븫 닔닠쓽 쟾 泥섏 빟臾쇰줈뜥 븸쓽 遺꾨퉬瑜 媛먯냼떆궎뒗뜲, 씠뒗 븸꽑뿉 遺꾪룷븯뒗 臾댁뒪移대┛ 닔슜泥댁쓽 湲명빆 옉슜쑝濡 遺援먭컧 떊寃쎌쓣 뼲젣븿쑝濡쒖뜥 寃곌낵쟻쑝濡 援ш컯 젏留됱쓣 嫄댁“븯寃 븳떎뒗 뿰援 寃곌낵媛 엳떎(Miranda et al., 2015). Silverman쓽 뿰援ъ뿉꽌뒗 씤泥 궡濡 議곗궗릺뒗 諛⑹궗꽑씠 븸꽑 議곗쭅 궡뿉 吏諛 蹂꽦, 꽟쑀솕, 꽭룷 꽦遺꾩쓽 愿댁궗 諛 꽑룷쓽 쐞異 벑쓽 鍮꾧뿭쟻씤 넀긽쓣 씪쑝耳 援ш컯嫄댁“利앹쓣 쑀諛쒗븷 肉먮쭔 븘땲씪 븸쓽 pH 媛먯냼媛 씠猷⑥뼱吏꾨떎怨 蹂닿퀬븯떎(Silverman, 1999). 쁽옱 몴쟻씤 援ш컯嫄댁“利앹쓽 移섎즺젣뒗 誘멸뎅 떇뭹쓽빟援(FDA)쓽 듅씤쓣 諛쏆 꽭鍮꾨찞由(Cevimeline) 諛 븘濡쒖뭅瑜댄(Pilocarpine)씠 二쇰줈 泥섎갑릺뒗뜲, 꽭鍮꾨찞由곗 M3 臾댁뒪移대┛ 닔슜泥댁 媛뺥븳 寃고빀젰쓣 媛吏 븸꽑 옄洹뱀젣씠硫 븘濡쒖뭅瑜댄 臾댁뒪移대┛ 닔슜泥 以 遺援먭컧 떊寃쎌쓣 옄洹뱁븯뒗 빟臾쇱씠떎(Choi and Lim, 2016). 슚뒫씠 醫뗭 諛섎㈃뿉 遺옉슜룄 쟻吏 븡뜲, 꽕궗, 湲곌吏 異뺤냼, 鍮덈㎘, 삤떖 諛 援ы넗, 삁븬, 떆빞쓽 씠긽, 遺꾨퉬쓽 利앷, 삁븬, 뵾遺 삁愿쓽 솗옣 벑쓽 遺옉슜씠 蹂대룄릺怨 엳떎(Aframian et al., 2007). 肉먮쭔 븘땲씪 鍮 議곗젅꽦 怨좏삁븬 솚옄 諛 湲됱꽦 쐞沅ㅼ뼇 솚옄뿉寃 젣븳쟻 泥섎갑쓣 븯怨 踰좏 李⑤떒젣 궗슜 以묒씤 솚옄, 鍮 議곗젅꽦 泥쒖떇 솚옄, 留뚯꽦 룓吏덊솚 솚옄뿉寃 泥섎갑쓣 湲덊븳떎(Aframian et al., 2007).

끂씤 吏묐떒뿉꽌 二쇰줈 샇냼븯뒗 援ш컯嫄댁“利앹쑝濡 씤븯뿬 떎뼇븳 뿰愿넻쓣 샇냼븯뒗 寃껋쑝濡 븣젮졇 엳뒗뜲, 援ш컯븞硫대뒗 떎뼇븳 援ъ“ 諛 湲곕뒫쑝濡 援ъ꽦릺뼱 엳쑝硫 떊寃쎌쓽 遺꾪룷媛 蹂듭옟븯怨 議곕븯뿬 넻利앹씠굹 吏덈퀝씠 諛쒖깮뻽쓣 寃쎌슦 蹂듭옟븯怨 떎뼇븳 엫긽 利앹긽쑝濡 굹굹뒗 寃쎌슦媛 留롫떎. 떎젣 援ш컯븞硫대쓽 넻利앹쑝濡 씤븯뿬 移섍낵瑜 궡썝븯뒗 鍮꾩쨷씠 넂 렪씤뜲 湲됱꽦怨 留뚯꽦, 蹂듯빀꽦쑝濡 諛쒖깮븯뒗 援ш컯븞硫대 넻利(orofacial pain) 븞硫대, 몢遺 諛 援ш컯 궡 援ъ“臾쇱쓽 寃쎌“吏 諛 뿰議곗쭅뿉 굹굹뒗 넻利앹씠 룷븿릺뒗 슜뼱濡, 移섏븘吏덊솚쓣 鍮꾨’븳 援ш컯 슫룞 옣븷瑜 쑀諛쒗븯硫 痢〓몢븯븙愿젅 옣븷(temporomandibular disorder, TMD)瑜 鍮꾨’븳 궪李⑥떊寃쏀넻怨 媛숈 떊寃쎈퀝利앹꽦 넻利 諛쒗쁽源뚯 떎뼇븳 吏덊솚뱾씠 쑀궗븳 삎깭쓽 룞넻쑝濡 굹굹 吏꾨떒씠 뼱젮슫 寃쎌슦媛 留롫떎(Choi et al., 2006). 몢넻씠굹 떊寃쎌꽦 넻利, 洹쇨낏寃⑹꽦 넻利, 떖씤꽦 넻利, 븫 벑쑝濡 씤빐 諛쒖깮릺뒗 넻利앹쓣 룷븿븯硫, 쑀諛쒕릺뒗 쟾떖 怨쇱젙뿉 궛솕쟻 뒪듃젅뒪媛 넂寃 옉슜븯뒗 寃껋쑝濡 븣젮졇 엳떎(Choi et al., 2006).

븞硫대 넻利앹 넀긽맂 議곗쭅쓽 꽭룷 諛 留먯큹떊寃쎌쓽 留먮떒 遺쐞 벑뿉꽌 prostaglandin, histamine, adenosine 5'-triphosphate (ATP), substance P, bradykinin, 벑쓽 뿼利앹꽦 臾쇱쭏뱾씠 쑀由щ릺뼱 諛쒖깮븳떎(Kim, 2006). 넻利앹쓣 쑀諛쒗븯뒗 씎遺꾩꽦 떊寃쎌쟾떖臾쇱쭏씤 ATP뒗 벂由(purine)怨 臾쇱쭏뱾怨 諛섏쓳릺뒗 닔슜泥댁뿉 寃고빀릺硫 씠삩 梨꾨꼸씠 뿴由щʼn 꽭룷留됱쓣 넻怨쇳븯뿬 留됱쟾쐞媛 蹂솕맂떎(Dunn et al., 2001). 씎遺꾩꽦 넻媛곸젙蹂닿 C 꽟쑀 諛 A-灌 꽟쑀 벑쓽 쑀빐닔슜湲(nociceptors)뿉 쓽빐 媛먯옉릺뼱 泥숈닔뿉 쟾떖릺硫 씪젴쓽 泥섎━ 怨쇱젙쓣 泥숈닔 썑媛곸뿉꽌 뇤 뵾吏덈줈 쟾떖릺뼱 넻利앹쓣 옄媛곹븯寃 릺뒗 寃껋씠떎(Kim, 2006).

븞硫대 넻利앹쑝濡 씤븳 移섎즺 諛⑸쾿쑝濡 媛 鍮꾩뒪뀒濡쒖씠뱶꽦 빟臾쇱씠 留롮씠 泥섎갑릺뒗뜲, 씠 빟臾쇱 吏꾪넻 슚怨쇨 쎇뼱굹吏留 옣湲곌컙 蹂듭슜 떆 삁쟾利 諛 쐞옣愿 룆꽦 諛섏쓳 벑쓽 遺옉슜룄 諛쒖깮맆 닔 엳뼱 二쇱쓽媛 븘슂븯떎(Kim and Lee, 2015). 빀꽦쓽빟뭹뿉 鍮꾪빐 理쒓렐뿉뒗 鍮꾧탳쟻 룆꽦씠 쟻怨 옣湲 蹂듭슜씠 媛뒫븯硫 蹂듯빀쟻씤 슚뒫쓣 媛吏 泥쒖뿰 臾쇱쭏뿉 븳 뿰援ш 솢諛쒗엳 吏꾪뻾릺怨 엳쑝硫 愿떖씠 넂븘吏怨 엳떎. 理쒓렐 뿰援ъ뿉 뵲瑜대㈃, 援ш컯븞硫 遺쐞뿉 씛 伊먯쓽 떎뿕룞臾쇱뿉꽌 湲됱꽦 넻利앹쓣 쑀諛쒗븳 뮘 슜洹, 룷怨듭쁺, 留덉튂쁽, 넗蹂듬졊 異붿텧臾쇱쓣 닾뿬 떆 넻利앹씠 寃쎄컧릺뒗 슚怨쇨 蹂닿퀬릺뿀쑝硫(Kim et al., 2018), Choi 벑쓽 뿰援ъ뿉꽌 蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 寃쎄뎄 닾뿬 떆 formalin쑝濡 쑀룄맂 븞硫대 諛 븙愿젅 넻利 紐⑤뜽뿉꽌 넻利 뻾쐞 諛섏쓳씠 쑀쓽븯寃 媛먯냼븯떎뒗 寃곌낵媛 蹂닿퀬릺뿀떎(Choi et al., 2018).

理쒓렐뿉뒗 븵꽌 뿴嫄고븳 빀꽦쓽빟뭹쓽 遺옉슜쓣 理쒖냼솕븯湲 쐞빐 援ш컯嫄댁“利앹쓣 鍮꾨’븳 떎뼇븳 吏덊솚쓣 긽쑝濡 泥쒖뿰 빟臾 移섎즺踰뺤씠 利앸릺怨 엳떎. 泥쒖뿰 臾쇱쭏 鍮꾧탳쟻 궙 룆꽦 꽦遺꾧낵 옣湲 蹂듭슜뿉 珥덈옒릺뒗 遺옉슜씠 궙 諛섎㈃ 빟由ъ쟻 슚뒫쓣 湲곕븷 닔 엳뼱 泥쒖뿰 臾쇱쭏뿉 븳 愿떖씠 넂븘吏怨 엳떎(Braga et al., 2009). 怨좊遺꽣 룞뼇 諛 꽌뼇뿉꽌뒗 빆궛솕젣 뼢떊猷뚯 떇뭹 遺뙣 諛뺥뀒由ъ븘 諛 떎뼇븳 蹂묒썝洹좎쓽 利앹떇쓣 뼲젣븯湲 쐞븯뿬 뿬윭 泥쒖뿰 臾쇱쭏뿉꽌 빟由 슚뒫쓣 솗蹂댄빐솕떎. 蹂 뿰援ъ뿉꽌 궗슜맂 cinnamaldehyde뒗 cinnamon oil쓽 二쇱꽦遺꾩쑝濡 끃굹臾 냽뿉 냽븯뒗 寃껋쑝濡 뤃由ы럹 꽦遺꾩씠 뭾遺븯뿬 넂 빆궛솕 옉슜쓣 뼢긽 떆궎뒗 寃껋쑝濡 븣젮졇 엳떎. 뿼利앹씠굹 슂濡 媛먯뿼씠굹 쐞옣 옣븷 諛 뿼利앹쓣 鍮꾨’븳 吏덈퀝쓽 移섎즺 紐⑹쟻쓽 嫄닿컯利앹쭊 臾쇱쭏씤옄濡 궗슜릺怨 엳쑝硫(Brierley and Kelber, 2011), cinnamon 굹臾닿퍖吏 3~6 g쓣 蹂듭슜븯硫 젣2삎 떦눊 솚옄뿉寃 媛먯냼맂 삁떦 닔移 蹂솕瑜 蹂닿퀬븯떎(Alam et al., 2003). 援ш컯 嫄닿컯 愿젴빐꽌뒗 援ъ랬 젣嫄, 移섑넻, 援ш컯 媛먯뿼뿉룄 긽썡븳 슚怨쇨 엳뒗 寃껋쑝濡 븣젮졇 엳떎(Chaudhary et al., 2013). 肉먮쭔 븘땲씪 꽕궗 諛⑹젣, 媛뺣젰븳 빆뿼젣, 媛곸꽦젣, 빆쓳怨좎젣 슚怨쇰 鍮꾨’븯뿬(Hossein et al., 2013), 삁븸 쓳怨 옉슜씠 엳뼱 異쒗삁씠 諛쒖깮뻽쓣 寃쎌슦 吏삁젣濡쒕룄 궗슜 媛뒫븯떎(Rao and Gan, 2014). 蹂 뿰援ъ뿉꽌룄 援ш컯吏덊솚쑝濡 뼢긽맂 援ш컯븞硫대 넻利앹쓽 議곗젅뿉 泥쒖뿰 빟臾쇰줈꽌쓽 떎뼇븳 깮由ы븰쟻 슚뒫씠 諛앺吏 cinnamaldehyde媛 슚怨쇱쟻씪 寃껋쑝濡 湲곕븯뿬 蹂 뿰援щ 吏꾪뻾븯떎.

뵲씪꽌 蹂 뿰援ъ뿉꽌뒗 理쒖쓽 꽑뻾 끉臾몄쓣 李멸퀬븯뿬(Choi et al., 2020) 4-DAMP瑜 蹂듦컯 궡濡 닾뿬븯뿬 援ъ텞맂 援ш컯嫄댁“利 紐⑤뜽뿉꽌 깮泥 諛섏쓳 蹂솕瑜 愿李고븯怨, 몴쟻쑝濡 援ш컯吏덊솚씠 쑀諛쒕릺뒗 遺쐞씤 떎뿕룞臾쇱쓽 븞硫대 諛 꽦愿젅 遺쐞뿉꽌 formalin쑝濡 쑀룄맂 뿼利앹꽦 넻利 紐⑤뜽뿉꽌쓽 cinnamaldehyde 넻利 뻾쐞 諛섏쓳 議곗젅 슚怨쇱뿉 빐 솗씤븯怨좎옄 븯떎. 슦꽑 cinnamaldehyde瑜 寃쎄뎄 닾뿬(Oral administration)븯뿬 쓬닔 웾, 泥댁쨷, 떇씠 꽠痍⑤웾, 븸 웾쓣 鍮꾧탳븯뿬 援ш컯嫄댁“利앹뿉 湲곗씤븯뒗 깮泥 蹂솕瑜 솗씤븯怨좎옄 븯떎. 삉븳 뼢긽맂 븞硫대 넻利앹쓽 뿭移 蹂솕瑜 愿李고빐 蹂닿퀬옄 4-DAMP瑜 닾뿬븯뿬 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궓 떎뿕룞臾쇱뿉 슦痢 닔뿼遺 뵾븯 諛 TMJ뿉 5% formalin쓣 二쇱엯븯뿬 넻利앹쓽 蹂솕瑜 솗씤븯怨, cinnamaldehyde쓽 寃쎄뎄 닾뿬븳 뮘 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궎怨 formalin쓣 룞씪븳 遺쐞뿉 닾뿬븳 寃쎌슦 넻利 議곗젅 슚怨쇨 굹굹뒗吏 솗씤븯怨좎옄 븯떎.

옱猷 諛 諛⑸쾿

떎뿕룞臾

蹂 떎뿕 뿰援ъ뿉꽌 궗슜맂 떎뿕룞臾쇱 슚李쎌궗씠뼵뒪(援)뿉꽌 怨듦툒 諛쏆븯쑝硫 깮썑 6~7二쇰졊쓽 Sprague-Dawley怨 닔而 씛 伊먯떎. 룞쓽븰援 룞臾 以鍮꾩떎뿉꽌 23~26꼦 삩룄 12떆媛 二 쨌 빞媛 鍮쏆쓽 닚솚 二쇨린媛 씪젙븳 솚寃쎌뿉꽌 궗쑁 諛 쑀吏븯떎. 蹂 뿰援щ뒗 룞쓽븰援 룞臾쇱떎뿕쑄由ъ쐞썝쉶뿉꽌 듅씤쓣 諛쏆븯쑝硫(R2018-011), 쓽떇 엳뒗 룞臾쇱뿉 븳 넻利앹뿰援ы븰쉶뿉꽌 洹쒖젙븳 쑄由 洹쒕쾾쓣 以닔븯뿬 떎뿕쓣 吏꾪뻾븯떎.

빟臾 젣議 諛 닾뿬 諛⑸쾿

4-DAMP 닾뿬 諛 븸 遺꾨퉬웾 痢≪젙: 떎뿕씠 떆옉릺湲 30遺 쟾뿉 닾紐낇븳 뵆씪뒪떛 넻뿉 떎뿕룞臾쇱쓣 쟻쓳떆耳 뒪듃젅뒪瑜 理쒖냼솕븯쑝硫, 떎뿕쓣 吏꾪뻾릺湲 쟾源뚯 궗猷 諛 臾쇱쓽 꽠痍⑤ 씪泥 湲덊븯쑝硫 理쒖쓽 꽑뻾 끉臾몄쓣 李멸퀬븯뿬(Choi et al., 2020) 룞씪븯寃 吏꾪뻾븯떎. 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궎湲 쐞븯뿬 떆洹몃쭏 븣뱶由ъ튂궗(Sigma-Aldrich Co., St. Luis, U.S.A)뿉꽌 援ъ엯븳 4-DAMP (1 mg/kg) 빟臾쇱쓣 蹂듦컯 궡뿉 1 mL쓽 슜웾쑝濡 닾뿬(intraperitoneal)븯떎. 떆媛꾩씠 寃쎄낵 븳 뮘 븞젙 쐞 긽깭瑜 쑀吏븯湲 쐞븯뿬 20% urethane쓣 0.5 mL/kg쓽 슜웾쑝濡 蹂듦컯 닾뿬븯떎. 븸 遺꾨퉬웾 硫멸퇏맂 硫 援(cotton ball)瑜 떎뿕룞臾쇱쓽 援ш컯 궡 븙븯꽑쓽 遺꾨퉬愿 媛쒓뎄 遺쐞뿉 쐞移섏떆궓 뮘 30遺꾧컙 臾닿쾶瑜 痢≪젙븯쑝硫, 븸쓣 씉닔븳 臾닿쾶瑜 븸 遺꾨퉬웾쑝濡 媛꾩<븯떎.

Cinnamaldehyde쓽 빟臾 닾뿬: Cinnamaldehyd뒗 떆洹몃쭏 븣뱶由ъ튂궗(Sigma-Aldrich Co., St. Luis, U.S.A)뿉꽌 援ъ엯븯쑝硫 20% DMSO뿉 슜빐떆궓 뮘 distilled water (D.W)뿉 5, 12.5, 25, 50 mg/kg (1 mL)쓽 냽룄 蹂꾨줈 씗꽍븯뿬 媛곴컖 1쉶 寃쎄뎄 닾뿬븯뿬 씪二쇱씪 媛 諛섏쓳쓣 愿李고븯怨좎옄 븯쑝硫 4-DAMP瑜 蹂듦컯뿉 닾뿬븯湲 30遺 쟾뿉 癒쇱 떎떆븯떎.

援ш컯嫄댁“利앹쑝濡 蹂솕맂 깮泥 諛섏쓳 痢≪젙: 援ш컯嫄댁“利앷낵 愿젴맂 깮泥 諛섏쓳 쓬닔 웾 떇씠 꽠痍⑤웾 諛 泥댁쨷쑝濡 援щ텇븯뿬 4-DAMP 닾뿬 썑 씪二쇱씪 媛 굹굹뒗 蹂솕瑜 痢≪젙븯怨, 쑀쓽븳 蹂솕瑜 굹궦 떎뿕룞臾쇱쓣 湲곗쑝濡 援ш컯嫄댁“利 紐⑤뜽쓣 솗由쏀븯떎. 理쒖쓽 꽑뻾 끉臾몄쓣 李몄“븯뿬(Choi et al., 2020) 泥댁쨷 떎뿕 쟾 썑 痢≪젙븯뿬 蹂솕맂 닔移섎 솗씤븯쑝硫 쓬닔 웾 臾쇰퀝뿉 250 mL 슜웾쓣 湲곗쑝濡 옍뿬웾쓣 痢≪젙븯怨 떇씠 꽠痍⑤웾룄 200 g쓽 궗猷뚮 怨듦툒븳 뮘 옍뿬웾쓣 痢≪젙븯뿬 떎젣 蹂듭슜웾쑝濡 媛꾩<븯뿬 痢≪젙븯떎. 삉븳 cinnamaldehyde瑜 냽룄 蹂꾨줈 媛곴컖 寃쎄뎄 닾뿬븯怨 30遺 寃쎄낵 썑 4-DAMP瑜 蹂듦컯 닾뿬븯뿬 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궓 떎쓬 깮泥 諛섏쓳뿉 蹂솕媛 엳뒗吏 솗씤빐 蹂닿퀬옄 븯떎.

쑀諛쒕맂 援ш컯嫄댁“利 紐⑤뜽뿉꽌 븞硫대 뿼利앹꽦 넻利 뿭移 蹂솕: 떎뿕룞臾쇱쓽 蹂듦컯 궡 4-DAMP 닾뿬濡 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궓 떎쓬 븞硫대뿉 5% formalin쓣 二쇱엯븯뿬 諛쒖깮릺뒗 뿼利앹꽦 넻利 뿭移섏쓽 蹂솕瑜 愿李고븯떎. 蹂듦컯 궡 4-DAMP瑜 닾뿬븯怨 30遺 寃쎄낵 썑 5% formalin쓣 씛 伊먯쓽 삤瑜몄そ 닔뿼 遺쐞뿉 50 關L 닾뿬븯뿬 븞硫대 뿼利앹꽦 넻利앹쓣 쑀諛쒖떆耳곗쑝硫, 빟臾쇱씠 二쇱엯맂 遺쐞瑜 踰쎌뿉 臾몄瑜닿굅굹 湲곷뒗 뻾쐞瑜 넻利 吏몴濡 媛꾩<븯떎. 깮由ъ떇뿼닔 1 mL瑜 蹂듦컯 닾뿬븳 na챦ve援곕룄 30遺꾩씠 寃쎄낵븳 뮘 룞씪븳 遺쐞뿉 5% formalin 50 關L쓽 룞씪 슜웾쑝濡 닾뿬븯뿬 넻利 뻾쐞 諛섏쓳쓣 愿李고븯쑝硫 떎뿕 꽑뻾 끉臾몄쓣 李멸퀬븯뿬 45遺 룞븞 5遺 떒쐞濡 뻾쐞 諛섏쓳쓣 湲곕줉븯떎(Yang et al., 2007).

쑀諛쒕맂 援ш컯嫄댁“利 紐⑤뜽뿉꽌 TMJ 넻利 뿭移 蹂솕: 뤃由ъ뿉떥젋 뒠釉 걹뿉 cannula瑜 30 gauge 몢猿섏쓽 二쇱궗諛붾뒛쓣 뿰寃곗떆耳곗쑝硫, 諛섎履쎌뿉뒗 0.25횞8 mm쓽 二쇱궗湲곕 뿰寃고븯뿬 TMJ 궡濡 formalin쓣 닾뿬븯怨좎옄 븯떎. 떎뿕룞臾쇱뿉 뿉뀒瑜대 씠슜븳 씉엯 留덉랬 썑 븯븙 怨쇰몢 遺쐞 愿怨④턿쓽 寃쎄퀎 遺쐞瑜 珥됱븯뿬 愿젅媛뺤쓽 쐞移섎 솗씤븳 뮘 븯븙쓽 떯뒗 遺쐞源뚯 愿젅媛 궡濡 二쇱궗諛붾뒛쓣 꽔뿀떎. Formalin (30 關L)瑜 10 關L瑜 5珥 룞븞 愿젅媛 궡 닾뿬븯쑝硫, 빟臾쇱쓣 二쇱엯븳 뮘 쓽떇씠 닔 珥 븞쑝濡 룎븘삤뒗 寃껋쓣 솗씤븯떎. TMJ 遺쐞瑜 湲곴굅굹 踰쎌뿉 臾몄瑜대뒗 뻾쐞 諛섏쓳쓣 5遺 媛꾧꺽쑝濡 9쉶瑜 痢≪젙븯뿬 珥 45遺꾧컙 湲곕줉븯쑝硫 1李 넻利 뻾쐞 諛섏쓳(first phase)씤 0~10遺꾧낵 2李 넻利 뻾쐞 諛섏쓳(second phase)씤 11~45遺 援щ텇븯뿬 愿李고븯떎.

넻怨 遺꾩꽍: IBM SPSS statistic ver. 20 (IBM Co., Armonk, NY, USA)쓣 궗슜븯쑝硫 援ш컯嫄댁“利앹쑝濡 씤븯뿬 쑀諛쒕맂 뿼利앹꽦 븞硫대 넻利 뻾쐞 諛섏쓳뿉 븳 寃곌낵뒗 紐⑤몢 룊洹 짹몴以 삤李(SEM)濡 몴떆븯쑝硫 P<0.05쓽 湲곗쑝濡 넻怨꾩쟻쑝濡 쑀쓽 븯떎怨 룊媛븯떎. 삉븳 씪썝遺꾩궛遺꾩꽍쓣 떆뻾븯뿬 諛섎났 痢≪젙옄猷뚮 遺꾩꽍뻽쑝硫 LSD post-hoc test瑜 씠슜븯뿬 궗썑 遺꾩꽍쓣 떎떆븯떎.

寃 怨

Cinnamaldehyde 닾뿬 썑 깮泥 諛섏쓳 蹂솕

Fig. 1 cinnamaldehyde瑜 닾뿬 썑 援ш컯嫄댁“利앹쓣 쑀諛쒗븳 紐⑤뜽뿉꽌 굹굹뒗 깮泥 諛섏쓳쓽 蹂솕씠떎. Na챦ve援, vehicle援, 4-DAMP, cinnamaldehyde 5 mg/kg (C5), cinnamaldehyde 12.5 mg/kg (C12.5), cinnamaldehyde 25 mg/kg (C25), cinnamaldehyde 50 mg/kg (C50)쑝濡 援щ텇븯뿬 떎뿕쓣 吏꾪뻾븯怨 슦꽑 븞젙 쐞 긽깭뿉꽌 쓬닔 웾, 떇씠 꽠痍⑤웾, 泥댁쨷 諛 븸 웾쓣 痢≪젙븳 뮘 씪二쇱씪 媛꾩쓽 蹂솕瑜 愿李고븯떎. 쓬닔 웾 na챦ve援 190 mL, vehicle援 167.5 mL, 4-DAMP援 208.8 mL瑜 쓬슜븳 諛섎㈃ C5援곗 175 mL, C12.5援곗 185 mL, C25援곗 182.5 mL, C50援곗 177.5 mL濡 굹굹 援ш컯嫄댁“利앹씠 쑀룄맂 4-DAMP援곗뿉꽌 쓬닔 웾씠 利앷븯쑝硫 cinnamaldehyde쓽 寃쎄뎄 닾뿬援곗뿉꽌뒗 媛먯냼븳 寃껋쓣 솗씤븯떎.

Fig. 1. Bioresponse following by 4-DAMP injection and cinnamaldehyde (5, 12.5, 25, 50 mg/kg) for 1 week compared control group and vehicle group (*P<0.05, vs 4-DAMP, n=6).

궗猷 꽠痍⑤웾 na챦ve援 162.5 g, vehicle援 155 g, 4-DAMP援 97.5 g씠쑝硫, C5援곗 92.5 g, C12.5援곗 105 g, C25援곗 142.5 g, C50援곗 142.5 g쑝濡쒖뜥 cinnamaldehyde瑜 닾뿬븳 洹몃9뿉꽌 利앷맂 뼇긽쓣 蹂댁떎.

泥댁쨷쓽 蹂솕뒗 na챦ve援 225 g, vehicle援 235 g, 4-DAMP援곗뿉꽌뒗 215 g쑝濡 굹궃 諛섎㈃ cinnamaldehyde瑜 닾뿬븳 援곗뿉꽌 C5援곗 220 g, C12.5援곗 235 g, C25援곗 235 g, C50援곗 227.5 g쑝濡 굹굹 cinnamaldehyde瑜 닾뿬븳 援곗뿉꽌 泥댁쨷씠 利앷븳 寃껋쑝濡 굹궗떎.

븸 遺꾨퉬웾쓣 痢≪젙븳 寃곌낵 na챦ve援곗 0.2520 g怨 vehicle援 0.2267 g, 4-DAMP援곗뿉 0.0030 g씠쑝硫 cinnamaldehyde 닾뿬援곗뿉꽌뒗 C5援 0.0016 g, C12.5援 0.0039 g, C25援 0.1441 g, C50援곗 0.150 g쑝濡 cinnamaldehyde 닾뿬援곗씠 냽룄 쓽議댁쟻쑝濡 븸 遺꾨퉬웾씠 利앷븳 寃껋쓣 솗씤븷 닔 엳뿀떎.

援ш컯嫄댁“利 쑀諛 썑 븞硫대 뿼利앹꽦 넻利 뿭移 蹂솕

Fig. 2뒗 4-DAMP瑜 닾뿬븯뿬 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궓 떎뿕援곗뿉꽌 븞硫대뿉 5% formalin쓣 二쇱엯븯뿬 굹굹뒗 뿼利앹꽦 넻利앹쓽 뿭移 蹂솕瑜 굹궡뿀떎. Na챦ve援곗 37.24짹1.21쉶, control援곗 302.5짹18.8쉶쑝硫 D.W formalin쓣 닾뿬븳 vehicle援곗뿉꽌뒗 315.7짹11.7씤 諛섎㈃ 478.7짹17.5쉶씤 4-DAMP援곗뿉꽌뒗 利앷븯쑝硫(P<0.05), 떆媛꾩뿉 뵲瑜 蹂솕瑜 궡렣蹂대㈃ 20遺꾩뿉꽌 40遺 떎뿕 떆젏뿉꽌 넻利 뻾쐞 諛섏쓳씠 利앷븳 寃껋쓣 솗씤븷 닔 엳뿀쑝硫 넻怨꾩쟻쑝濡쒕룄 쑀쓽븯떎.

Fig. 2. Nociceptive behavior responses increased following orofacial intraperitoneal injection of 4-DAMP (1 mg/kg) (n=6, respectively). *P<0.05, vs Vehicle + F (Formalin, F).

援ш컯嫄댁“利 쑀諛 썑 TMJ 뿼利앹꽦 넻利 뿭移 蹂솕

TMJ뿉꽌쓽 넻利 뿭移 蹂솕뒗 Fig. 3뿉 굹궡뿀떎. 븵꽌 븞硫대 넻利 蹂솕 닔移섏 룞씪븯寃 4-DAMP 닾뿬援곗뿉꽌룄 넻利앹쓽 媛먯닔꽦씠 뜑 넂 寃껋쑝濡 솗씤릺뿀떎. Na챦ve援 91짹14.5쉶, vehicle援 132짹8.2쉶씤 寃껋씤 諛섎㈃ 4-DAMP援곗뿉꽌뒗 251짹11쉶濡 利앷븳 寃껋쓣 솗씤븷 닔 엳뿀쑝硫 떆媛꾩뿉 뵲瑜 蹂솕뒗 15~30遺 寃쎄낵 떆젏뿉꽌 넻利 뻾쐞媛 利앷븯怨 넻怨꾩쟻쑝濡 쑀쓽븯떎.

Fig. 3. Nociceptive behavior responses increased following TMJ intraperitoneal injection of 4-DAMP (1 mg/kg) (n=6, respectively). *P<0.05, vs Vehicle + F (Formalin, F).

븞硫대 뿼利앹꽦 넻利 蹂솕뿉 cinnamaldehyde 닾뿬媛 誘몄튂뒗 쁺뼢

Fig 4뒗 cinnamaldehyde 닾뿬濡 븞硫대 뿼利앹꽦 넻利 蹂솕濡 寃곌낵뒗 4-DAMP援 462.6짹15.2쉶, vehicle援 404.7짹8.71쉶濡 굹궗쑝硫 cinnamaldehyde 닾뿬援곗뿉꽌뒗 C5援 337.5짹9.83쉶, C25援 198.3짹5.17쉶, C50援 69짹8.83쉶濡 넻利 뻾쐞 諛섏쓳 슏닔媛 넻怨꾩쟻쑝濡 쑀쓽븯寃 媛먯냼븯쑝硫 떆媛 寃쎄낵 蹂 寃곌낵뿉꽌뒗 15~40遺 吏젏뿉꽌 넻怨꾩쟻쑝濡 쑀쓽븳 媛먯냼맂 닔移섎줈 愿李곕릺뿀떎.

Fig. 4. Effects of cinnamaldehyde in orofacial on nociceptive behavior. Changes in nociceptive responses following administration of cinnamaldehyde. *P<0.05, vs 4-DAMP+F, #P<0.05, VS vehicle+F (Formalin, F), n=6).

TMJ 넻利 蹂솕뿉 cinnamaldehyde 닾뿬媛 誘몄튂뒗 쁺뼢

Fig 5뒗 cinnamaldehyde瑜 寃쎄뎄 닾뿬븳 썑 4-DAMP瑜 蹂듦컯 닾뿬븯뿬 援ш컯嫄댁“利앹쓣 쑀諛쒖떆궓 紐⑤뜽뿉꽌 TMJ뿉 뿼利앹꽦 넻利 뻾쐞 蹂솕씠떎. 4-DAMP援 251.8짹8.8쉶, vehicle援 112짹11.2쉶怨, cinnamaldehyde瑜 닾뿬븳 뮘 寃곌낵뒗 C5援곗 169.3짹9쉶, C12.5援곗 198.3짹8.5쉶, C25援곗 41짹8.83쉶濡쒖뜥 냽룄 쓽議댁쟻쑝濡 넻利앹씠 媛먯냼븳 寃껋쓣 솗씤븷 닔 엳뿀쑝硫 넻怨꾩쟻쑝濡 쑀쓽븯떎. 떆媛꾩쓽 寃쎄낵뿉 뵲瑜 寃곌낵뒗 15~40遺 吏젏씤 2李 넻利 뻾쐞 諛섏쓳뿉꽌 na챦ve援곗뿉 鍮꾪븯뿬 넻怨꾩쟻쑝濡 쑀쓽븯寃 媛먯냼릺뿀떎.

Fig. 5. Effects of cinnamaldehyde in orofacial on nociceptive behavior. Changes in nociceptive responses following administration of cinnamaldehyde. *P<0.05, vs 4-DAMP+F, #P<0.05, VS vehicle+F (Formalin, F), n=6).
怨 李

븞硫대 넻利앹 씪깮 룞븞 理쒖냼 70% 씠긽쓽 궗엺뱾씠 移섍낵뿉꽌 솚옄뱾씠 샇냼븯뒗 吏덊솚씠떎(Lee et al., 2017). 넻利 諛쒖깮 썝씤 援ш컯 궡 슂씤쑝濡 諛쒖깮릺뒗 넻利앷낵 洹쇱쑁吏덊솚 諛 꽦愿젅쓣 룷븿븯뒗 TMD (Temporomandibular joint dysfunction)媛 媛옣 鍮덈쾲븯寃 굹궃떎(Dworkin and LeResche, 1992). 뿼利 諛쒖깮씠굹 議곗쭅 넀긽 벑쑝濡 諛쒖깮릺뒗 넻利앹 遺덉풄븳 媛먭컖利앹꽭 떖由ъ쟻 寃쏀뿕쓣 넻빐 넻利앹꽦 떊寃쎌쟾떖臾쇱쭏씠 쑀由щ릺硫 꽭룷留됱쓽 닔슜湲곗뿉 씎遺꾩꽦 솢룞쟾쐞媛 옉슜븯寃 맂떎(Richard and Clifford, 2000). 쁽옱 넻利앹쓽 젙룄瑜 議곗젅쓣 쐞븯뿬 臾쇰━슂踰, 빟臾쇱슂踰, 젅씠 移섎즺, 쟾湲 移섎즺 벑씠 媛쒕컻릺뼱 씠슜릺怨 엳쑝굹 긽쟻쑝濡 遺옉슜씠 쟻 泥쒖뿰 臾쇱쭏뿉 븳 愿떖씠 넂븘吏怨 엳쑝硫, 떎젣濡 엫긽쟻쑝濡 떎뼇븯寃 솢슜 以묒씠떎.

理쒓렐 寃쏀뼢쓣 諛뷀깢쑝濡 蹂 뿰援ъ뿉꽌뒗 援ш컯嫄댁“利앹쑝濡 뼢긽맂 븞硫대 TMJ 遺쐞쓽 뿼利앹꽦 넻利 議곗젅뿉 cinnamaldehyde媛 쁺뼢쓣 誘몄튂뒗吏 솗씤븯怨좎옄 븯떎.

援ш컯븞硫대뒗 떊寃쎌쓽 遺꾪룷媛 議곕븯怨 蹂듭옟븯寃 씠猷⑥뼱議뚭퀬 援ъ“ 湲곕뒫씠 떎뼇븯硫 떊泥댁쟻 諛 떖由ъ쟻 議곌굔뿉 쓽빐꽌룄 留롮 쁺뼢쓣 諛쏄퀬 엳湲 븣臾몄뿉 씠怨녹뿉 넻利앹씠굹 吏덈퀝씠 諛쒖깮뻽쓣 븣 굹굹뒗 엫긽 利앹긽씠 留ㅼ슦 떎뼇븯怨 蹂듭옟븳 뼇긽쓣 씈뒗 寃쎌슦媛 留롫떎(Korean academy of orofacial pain and oral medicine). 씠윭븳 援ъ“濡 씤븯뿬 떎젣 넻利앹쓣 씪쑝궎뒗 議곗쭅 遺쐞뿉꽌 嫄곕━媛 엳뒗 吏젏뿉꽌 넻利앹쓣 뒓겮뒗 뿰愿넻쓣 샇냼븯뒗 寃쎌슦룄 쟻吏 븡떎(Guyton and Hall, 2000). 34꽭 뿬옄 솚옄쓽 紐⑸퉿洹 뇙怨⑤몢쓽 넻利 쑀諛 吏젏쑝濡 씤븯뿬 씠넻쓣 샇냼븯뿬 꽦긽떊寃쎌젅李⑤떒닠쓣 떆뻾븳 利앸媛 蹂닿퀬릺뿀쑝硫(Seo et al., 2004), 삉븳 긽븙 醫뚯륫 移섏븘 諛 移섏< 遺쐞쓽 넻利앹쑝濡 궡썝븳 솚옄쓽 吏꾨떒 寃곌낵 醫뚯륫 빐硫댁젙留λ룞쓽 寃쎄퀎뿉 援ы삎 醫낃눼濡 씤븳 떊寃쎌젅 븬諛뺤쑝濡 媛먮쭏굹씠봽(gamma-knife) 닔닠쓣 떆뻾븳 利앸瑜 솗씤븷 닔 엳뿀떎(Yoon et al., 2008). 援ш컯嫄댁“利 諛 븞硫대 넻利 利앹긽怨쇱쓽 뿰愿꽦쓣 二쇱옣븯뒗 뿰援щ룄 蹂닿퀬릺뿀뒗뜲, 븞硫대 넻利앹쓣 샇냼븯뒗 솚옄援곗뿉꽌 援ш컯 嫄댁“媛, 옉쓽 뼱젮, 誘멸컖 긽떎, 鍮꾩젙긽쟻씤 븸 遺꾨퉬 벑쓽 蹂솕媛 굹궃 寃껋쑝濡 솗씤릺뿀쑝硫(Silva et al., 2011) 蹂 뿰援ъ뿉꽌룄 룞씪븳 寃곌낵瑜 굹궡뿀떎.

슦꽑 빆궛솕 옉슜 諛 빆뿼利앹꽦 듅吏뺤쓣 媛吏怨 엳뒗 cinnamaldehyde뒗 泥쒖뿰臾쇰줈뜥 4-DAMP 닾뿬븯뿬 쑀룄맂 援ш컯嫄댁“利 紐⑤뜽뿉꽌 븸 遺꾨퉬뿉 쁺뼢쓣 誘몄튂뒗吏 궡렣蹂닿퀬옄 븯떎. 슦꽑 cinnamaldehyde瑜 寃쎄뎄 닾뿬븳 뮘 諛쒖깮릺뒗 깮泥 諛섏쓳쓣 궡렣蹂대㈃ 쓬닔 웾 4-DAMP援곗뿉 鍮꾪빐 紐⑤뱺 cinnamaldehyde 냽룄援곗뿉꽌 넻怨꾩쟻쑝濡 쑀쓽븯寃 媛먯냼릺뿀쑝硫, 떇씠 꽠痍⑤웾 泥대줈 利앷븳 寃쏀뼢쓣 蹂댁怨 듅엳 C25, C50援곗뿉꽌 넻怨꾩쟻쑝濡 쑀쓽븳 利앷꽭瑜 愿李고븯떎. 븸 遺꾨퉬웾 뿭떆 cinnamaldehyde 닾뿬援곗뿉꽌 냽룄 쓽議댁쟻씤 利앷꽭쑝硫 泥댁쨷 떎뿕援곗뿉꽌 紐⑤몢 利앷 븯怨 듅엳 C12.5, C25援곌낵 C50援곗뿉꽌 쑀쓽븯떎. 꽑뻾 끉臾몄뿉꽌 떎떆븳 떒諛깆젙웾遺꾩꽍 떎뿕뿉꽌룄 4-DAMP 援곗뿉 鍮꾪븯뿬 cinnamaldehyde 닾뿬援곗뿉꽌 AQP5쓽 諛쒗쁽웾씠 利앷븯뜕 寃곌낵 씪移섑븯떎(Choi et al., 2020).

삉븳 cinnamaldehyde瑜 븞硫대쓽 냽룄뒗 C5, C25, C50, TMJ 遺쐞 냽룄뒗 C5, C12.5, C25濡 媛곴컖 닾뿬븯쓣 븣 넻怨꾩쟻쑝濡 쑀쓽븯寃 넻利앹씠 냽룄 쓽議댁쟻쑝濡 媛먯냼릺뒗 寃곌낵瑜 蹂댁떎. 理쒓렐 뿰援 寃곌낵뱾쓣 궡렣蹂대㈃ 븞硫 遺쐞 넻利 議곗젅留 븘땲씪 뿼利 議곗젅뿉 cinnamaldehyde쓽 슚뒫씠 엯利앸릺怨 엳떎. 理쒓렐 븳 뿰援 寃곌낵 蹂닿퀬뿉 뵲瑜대㈃, cinnamaldehyde쓽 寃쎄뎄 닾뿬濡 씤븯뿬 怨쇰떦쑝濡 궗 利앺썑援곗쓣 쑀諛쒗븳 떎뿕 紐⑤뜽쓽 떖옣 議곗쭅뿉꽌 IL-1棺 닔移섏쓽 媛먯냼濡 씤븯뿬 떖옣 뿼利앹씠 媛쒖꽑릺뒗 寃껋쓣 솗씤븷 닔 엳뿀쑝硫(Kang et al., 2016), 븣젅瑜닿린 鍮꾩뿼쓣 쑀諛쒗븳 씛 伊 떎뿕 紐⑤뜽뿉꽌 cinnamaldehyde 蹂듭슜쑝濡 寃쎄컧맂 븣젅瑜닿린 利앹긽怨 젏留됯퀬쑀痢, 샇궛援 닔 諛 삁옣꽭룷쓽 뿼利앹꽦 꽭룷쓽 移⑥쑄씠 媛먯냼맂 떎뿕 寃곌낵媛 蹂닿퀬릺뿀떎(Hanc캇 et al., 2016). 씠윭븳 뿰援 寃곌낵 씪移섑븯寃 蹂 뿰援ъ뿉꽌룄 cinnamaldehyde쓽 寃쎄뎄 닾뿬媛 formalin쓽 닾뿬濡 쑀諛쒕맂 뿼利앹꽦 븞硫대 諛 TMJ 넻利 뻾쐞 諛섏쓳뿉꽌 넻怨꾩쟻쑝濡 쑀쓽븯寃 媛먯냼릺뒗 寃껋쓣 愿李고븿쑝濡쒖뜥 넻利 議곗젅 諛 寃쎄컧뿉 슚怨쇱쟻쑝濡 쟻슜맂떎뒗 寃껋쓣 엯利앺븷 닔 엳뿀떎.

蹂 뿰援ъ뿉꽌 4-DAMP 닾뿬濡 쑀룄맂 援ш컯嫄댁“利앷낵 利앷맂 뿼利앹꽦 븞硫대 諛 TMJ 넻利 議곗젅뿉 cinnamaldehyde媛 愿뿬븳떎뒗 寃껋쓣 븣 닔 엳뿀떎. 蹂 뿰援ъ쓽 젣븳젏쑝濡 븞硫대 넻利앹쓽 깮깭蹂묐━븰쟻씤 湲곗쟾쓣 떎猷⑥ 紐삵븯吏留 떎뿕 寃곌낵瑜 諛뷀깢쑝濡 cinnamaldehyde媛 援ш컯嫄댁“利 諛 뼢긽맂 뿼利앹꽦 븞硫대 넻利앷낵 뿰愿꽦씠 넂떎뒗 寃껋쓣 솗씤븷 닔 엳뿀떎. 뵲씪꽌 썑냽 뿰援ъ뿉꽌뒗 cinnamaldehyde媛 븸 遺꾨퉬 諛 援ш컯븙븞硫 넻利앹쓽 떊샇瑜 留ㅺ컻븯뒗 쟾떖 臾쇱쭏쓣 諛쒗쁽 諛 洹쒕챸븯뒗 뿰援ш 븘슂븷 寃껋쑝濡 蹂댁씤떎. 씠긽쓽 寃곌낵瑜 醫낇빀빐蹂대㈃, cinnamaldehyde뒗 援ш컯吏덊솚 以 븯굹씤 援ш컯嫄댁“利앹쓣 鍮꾨’븳 븞硫대 넻利 議곗젅쓽 삁諛 諛 移섎즺젣쓽 븞씠 맆 닔 엳쓣 寃껋씠씪 궗猷뚮맂떎.

ACKNOWLEDGEMENT

None.

CONFLICT OF INTEREST

The authors have no conflict of interest with the publication of this article.

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