Dan Jin , Seung Kyu Park , Young Mi Lee , Yang Suk Yoon Dong Heui Kim , Young Kun Deung; Kyu Jae Lee

" /> Mineral-induced alkaline-reduced water (MRW); High-fat diet; Obesity Dan Jin , Seung Kyu Park , Young Mi Lee , Yang Suk Yoon Dong Heui Kim , Young Kun Deung and Kyu Jae Lee

" /> Dan Jin , Seung Kyu Park , Young Mi Lee , Yang Suk Yoon Dong Heui Kim , Young Kun Deung and Kyu Jae Lee

. BSL 2006;12:1-7. https://doi.org/">

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Effect of Mineral-induced Alkaline Reduced Water on Sprague-Dawley Rats Fed on High-fat Diet

J. Exp. Biomed. Sci. 2006;12:1-7
Published online March 31, 2006
© 2006 The Korean Society For Biomedical Laboratory Sciences.

Dan Jin 1,5, Seung Kyu Park 2, Young Mi Lee 4, Yang Suk Yoon 4, Dong Heui Kim 3, Young Kun Deung 3 and Kyu Jae Lee 2†


1Department of Microbiology,
2Department of Parasitology and Institutes for Basic Medical Science, and

3Department of Basic Science, Wonju College of Medicine, Yonsei University, Wonju, Gangwon 220-701, Korea.

4Biotech Research Institute, HDr Co., Ltd., 1214-6, Heung Yang-Ri, Socho-myun, Wonju, Gangwon 220-836, Korea.

5Department of Microbiology and Immunology, Yanbian University College of Medicine, Yanji 133000, China

Correspondence to:

Kyu Jae Lee,

Department of Parasitology and Institutes for Basic Medical Science, Wonju College of Medicine, Yonsei

University, Wonju, Gangwon, 220-701, Korea.

Tel: +82-33-741-0331, Fax: +82-33-731-6953

e-mail: kjlee@wonju.yonsei.ac.kr

Received December 18, 2005; Revised February 17, 2006; Accepted February 17, 2006.
 Abstract

Mineral-induced alkaline-reduced water (MRW) is generated by the chemical reaction of water with alkaline earth metals and characterized by high pH and low oxidation-reduction potential. As ROS are believed to have a role in the pathogenesis of obesity, we attempted to determine the effect of MRW on obesity in Sprague-Dawley (SD) rats fed on a high-fat diet. The body weight of the MRW group was significantly lower than that of the control group in most periods of the examination (P<0.05). Serum level of triglycerides (P<0.05) and fat deposition in the livers of the MRW group were found to have been significantly reduced. This suggests that MRW down-regulates lipid metabolism, thereby suppressing obesity. Possible mechanisms of MRW related to reactive oxygen species were also discussed. Our results suggest that MRW is effective in the alleviation of obesity in SD rats fed on high-fat diet.

Keywords :

Mineral-induced alkaline-reduced water (MRW), High-fat diet, Obesity