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Infection with Citrobacter rodentium in μMT Knockout Mice
Biomed. Sci. Lett. 2018;24:1-8
Published online March 31, 2018;
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Minjeong Jo, Soonjae Hwang and Ki-Jong Rhee

Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University at Wonju, Wonju, Gangwon-do 26493, Korea
Correspondence to: Ki-Jong Rhee. Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University, Wonju 26493, Korea. Tel: +82-33-760-2445, Fax: +82-33-760-2195, e-mail:
Received February 7, 2018; Revised February 26, 2018; Accepted March 2, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
μMT knockout mice are genetically deficient in the transmembrane domain of mu chain of the immunoglobulin M (IgM) heavy chain, resulting in the absence of mature B cells. μMT knockout mice is an in vivo model system used to clarify the role of B cells in various diseases. Enteropathogenic Escherichia coli (EPEC) induces acute and chronic diarrheal disease, especially in children of developing countries. The formation of attaching and effacing (A/E) lesion is a prominent pathogenic factor in the intestinal epithelium of EPEC infection. The A/E lesion is modulated by genes located on the pathogenic island locus of enterocyte effacement (LEE) which encode a type III secretion system (T3SS) and A/E lesion-related effector proteins. Citrobacter rodentium is a murine pathogen utilized in studying the pathogenic mechanisms of EPEC in human infections. Citrobacter rodentium produce A/E lesion to attach to intestinal epithelium, thus providing a murine model pathogen to study EPEC. Several studies have investigated the pathogenesis of Citrobacter rodentium in the μMT knockout mice. In this review, we introduce the μMT murine model in the context of C. rodentium pathogenesis and describe in detail the role of B cells and antibodies in this disease.
Keywords : μMT knockout mice, B lymphocyte, Colitis, Antibodies