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Cardamonin Inhibits the Expression of Inducible Nitric Oxide Synthase Induced by TLR2, 4, and 6 Agonists
Biomed Sci Letters 2018;24:102-107
Published online June 30, 2018;  https://doi.org/10.15616/BSL.2018.24.2.102
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Ah-Yeon Kim1,§, Hyun-Jin Shim1,§, Su-Yeon Kim1, Sung-Hye Heo1 and Hyung-Sun Youn1,†

1Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 31538, Korea
Correspondence to: Hyung-Sun Youn. Department of Biomedical Laboratory Science, College of Medical Sciences, SoonChunHyang University, Chungnam, Asan 31538, Korea.
Tel: +82-41-530-3086, Fax: +82-41-530-3085, e-mail: hyoun@sch.ac.kr
§Both authors contributed equally to this work.
Received April 16, 2018; Revised June 11, 2018; Accepted June 15, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Toll-like receptors (TLRs) play an important role for host defense against invading pathogens. The activation of TLRs signaling leads to the activation of NF-κB and the expression of pro-inflammatory gene products such as cytokines and inducible nitric oxide synthase (iNOS). To evaluate the therapeutic potential of cardamonin, which is a naturally occurring chalcone from Alpinia species (zingiberaceous plant species), NF-κB activation and iNOS expression induced by MALP-2 (TLR2 and TLR6 agonist) or LPS (TLR4 agonist) were examined. Cardamonin inhibited the activation of NF-κB induced by MALP-2 or LPS. Cardamonin also suppressed the iNOS expression induced by MALP-2 or LPS. These results suggest that cardamonin has the specific mechanism for anti-inflammatory responses by regulating of TLRs signaling pathway.
Keywords : Cardamonin, Inducible nitric oxide synthase, TLR, Inflammation, LPS