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Orofacial Pain Anti-Inflammatory Activity of Extracts of Boswellia Serrata in Rats
Biomed Sci Letters 2018;24:239-244
Published online September 30, 2018;  https://doi.org/10.15616/BSL.2018.24.3.239
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Ja-Hyeong Choi*, Kyung-Yae Hyun**, and Min-Kyung Lee†,**

Department of Biomedical Health Science, Dong-eui University, Busan 47340, Korea
Correspondence to: Min-Kyung Lee. Department of Biomedical Health Science, Dong-eui University, 176 Eongwangno(gayadong san24), Busanjin-gu, Busan 47340, Korea. Tel: +82-51-890-4238, Fax: +82-0505-182-6878, e-mail: lmk849@deu.ac.kr
Received July 26, 2018; Revised August 30, 2018; Accepted August 31, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract

Recently, many researches regarding the natural products which alternate with chemical products have been done. Among them, boswellia is well known for effect on anti-oxidative effect and inflammation. The aim was the effect boswellia of formalin- induced orofacial and temporomandibular joint (TMJ) pain on experimental animals was investigated. Experiments were carried out using subcutaneous (SC) pain model and TMJ pain model that were induced by the injection of 5% formalin into the right vibrissa pad (SC, 50 μL) or TMJ (30 μL) of rats, respectively. In both models, formalin (5%), formalin after distilled water (vehicle), formalin after boswellia extract (p.o., concentrations of 15, 30 mg/kg) (n=6). The number of scratching on the injected region was scored during the 9 successive periods of 5 min intervals following injection of formalin. Oral administration of boswellia (15, 30 mg / kg) reduced formalin-induced SC orofacial pain behavioral responses. SC orofacial pain behavioral responses was significantly reduced at 20~35 min. In the experimental group injected into temporomandibular joints, the pain response was significantly reduced by 276.2 ± 8.20 and 78.3 ± 4.7 after oral administration of boswellia (15, 30 mg / kg) at 398.3 ± 24.8 times. As a result of the passage of time, the oral administration of boswellia showed a significant effect of reducing the temporomandibular joint pain 30 minutes after the injection of formalin. This study confirmed that oral administration of boswellia modulated the pain behavior in both models. In conclusion, boswellia extract may be a potential therapeutic treatment for orofacial pain.

Keywords : Boswellia extract, Orofacial pain, Temporomandibular joint (TMJ)
꽌濡

븞硫대 넻利앹 移섏<議곗쭅씠씪 씪而ル뒗 移섏븘, 뿰議곗쭅, 移섏“怨⑥쓣 룷븿븯뿬 븙愿젅뿉 遺덊렪媛먯씠굹 넻利앹쓣 뒓겮뒗 寃껋쓣 쓽誘명븳떎. 씠윭븳 넻利앹 議곗쭅 옄泥댁뿉 넀긽쓣 二쇨굅굹 옞옱쟻씤 넀긽쓣 以 닔 엳뒗 쑀빐 옄洹뱀뿉 쓽빐 굹굹뒗 씪醫낆쓽 寃쎄퀬꽦 媛먭컖씤 넻媛(nociceptive pain), 넀긽맂 議곗쭅怨 洹 二쇰議곗쭅쑝濡쒕꽣 솢꽦솕릺뼱 遺꾨퉬릺뒗 interleukin-1β 벑쓽 뿼利앹꽦 留ㅺ컻臾쇰뱾(Kim et al., 2014)씠 쑀빐 媛먯닔湲곗뿉 옉슜븯뿬 굹굹뒗 뿼利앹꽦 넻利(inflammatory pain), 洹몃━怨 留먯큹 以묒텛 떊寃쎌쓽 옄泥 넀긽쑝濡 씤빐 쑀빐븯吏 븡 옄洹뱀뿉룄 吏냽쟻쑝濡 굹굹뒗 떊寃쎈퀝利앹꽦 넻利(neuropathic pain)쑝濡 援щ퀎맆 닔 엳떎(Kim and Jung, 2002; Min and Kim, 2008). 뿼利앹꽦 넻利앹 넀긽맂 떊泥닿 쉶蹂듬맆 븣源뚯 蹂댄샇 옉슜쓣 븯뿬 옞옱쟻씤 쐞뿕 긽솴쑝濡쒕꽣 踰쀬뼱궇 닔 엳怨, 李⑦썑 諛쒖깮맆 닔 엳뒗 긽솴뿉 鍮꾪븯뒗 뿭븷쓣 븷 닔 엳떎. 뿼利앹쓣 쑀諛쒗븯뒗 留ㅺ컻泥닿 젣嫄곕릺怨 遺꾨퉬맂 留ㅺ컻泥닿 뙆愿대릺嫄곕굹 씓뼱吏硫 醫낅즺릺뒗뜲 씠윭븳 뿼利앹꽦 넻利앹쓣 젣濡 移섎즺븯吏 븡쓣 寃쎌슦 뿼利앹씠 吏냽릺뼱 留먯큹 떊寃쎌쓽 넀긽 벑쑝濡 씤븯뿬 떊寃쎈퀝利앹꽦 넻利(neuropathic pain)쑝濡 吏꾪뻾릺뼱 留뚯꽦 넻利앹쓽 썝씤씠 맆 닔 엳湲 븣臾몄뿉 珥덇린 移섎즺媛 以묒슂븯떎(Min and Kim, 2008). 뿼利앹꽦 諛섏쓳쓣 議곗젅븯怨 닕二쇱뿉 怨쇰룄븳 넀긽쓣 二쇱 븡룄濡 븯뒗 솢꽦 빆뿼利 湲곗쟾 移섎즺젣媛 媛쒕컻릺뼱 궗슜릺怨 엳怨, 留롮 빆뿼利앹젣(NSAID 肄붾Ⅴ떚肄 뒪뀒濡쒖씠뱶 紐⑤몢)媛 媛쒕컻릺뿀吏留 븞쟾꽦 봽濡쒗뙆씪 뿰援ъ뿉꽌 뼱뒓 寃껊룄 遺꾨챸엳 븞쟾븯吏 븡떎뒗 寃껋쓣 蹂댁뿬二쇨퀬 엳떎(Ganapathy et al., 2011). 理쒓렐뿉 빀꽦 諛 솕븰 빟뭹쓽 遺옉슜쑝濡 씤븯뿬 씠瑜 泥댄븷 留뚰븳 깮臾쇳븰쟻 솢꽦 꽦遺꾩씠 遺꾨━맂 泥쒖뿰臾쇱쓽 씠슜쑝濡 떎뼇븳 吏덈퀝뿉 븳 깉濡쒖슫 븞 移섎즺踰뺤쑝濡 몢릺怨 엳떎(Colegate and Molyneux, 1993).

蹂댁뒪쎇由ъ븘(Boswellia Serrata)뒗 븘씪鍮꾩븘, 븘봽由ъ뭅 遺곷룞遺 빐븞 諛 씤룄 諛 以묐룞쓽 嫄댁“븳 궛븙 吏뿉꽌 옄씪뒗 以묐벑룄 겕湲 以 겙 겕湲 삎깭쓽 遺꾩 굹臾(Leung and Foster, 1996)濡 紐⑤뱺 뿴 吏諛⑹뿉꽌 꼻寃 띁吏 17쓽 냽 諛 600쓽 醫낆쓣 媛吏怨 엳쑝硫 怨좊遺꽣 誘쇨컙 슂踰뺤뿉꽌 泥쒖뿰 吏꾪넻젣濡 遺덈━硫 뿼利 諛 媛먯뿼 吏덊솚쓣 移섎즺븯湲 쐞븳 떎뼇븳 쟻쓳利앹쑝濡 궗슜릺뼱 솕떎. 뿼利앹꽦 吏덊솚쓽 寃쎌슦 泥대궡뿉 뿼利 留ㅺ컻씤옄씤 瑜섏퐫듃由ъ뿏(Leukotriene)씠 利앷븯뒗뜲, 蹂댁뒪쎇由ъ븘뒗 5-lipoxygenase씪뒗 슚냼 諛쒖깮쓣 뼲젣븯뿬 삤硫붽-6 吏諛⑹궛뿉 냽븯뒗 븘씪궎룉궛(Arachidonic acid)쓣 瑜섏퐫듃由ъ뿏쑝濡 쟾솚릺뒗 寃껋쓣 留됱븘 뿼利앹꽦 吏덊솚뿉 슚怨쇱쟻씠硫 옄媛硫댁뿭吏덊솚쑝濡 씤븳 뿼利앸컲쓳쓽 議곗젅뿉룄 슚怨쇱쟻씤 寃껋쑝濡 븣젮졇 엳떎(Ganapathy et al., 2011). 蹂댁뒪쎇由ъ븘뒗 븫(Shao et al., 1998), 뿼利(Singh and Atal, 1986), 愿젅뿼(Sharma et al., 1989), 泥쒖떇(Gupta et al., 1998), 嫄댁꽑(Chopra et al., 1956), 옣뿼(Gupta et al., 2001), 怨좎삁利(Pandey et al., 2005) 벑怨 媛숈 떎뼇븳 吏덈퀝쓽 移섎즺 紐⑹쟻쑝濡 궗슜릺怨 엳떎. 洹몃윭굹 븘吏곴퉴吏 蹂댁뒪쎇由ъ븘쓽 뿼利앹꽦 븞硫대쐞 紐⑤뜽뿉꽌 넻利앷꼍媛먰슚怨쇰 뿰援ы븳 蹂닿퀬뒗 嫄곗쓽 쟾臾댄븳 떎젙씠떎.

뵲씪꽌 蹂 뿰援щ뒗 룷瑜대쭚由곗쑝濡 쑀룄븳 떎뿕룞臾쇱쓽 븞硫대 븙愿젅 넻利, 몢 紐⑤뜽쓣 쟻슜븯뿬 蹂댁뒪쎇由ъ븘쓽 넻利앺뻾쐞諛섏쓳 議곗젅슚怨쇱뿉 빐 솗씤븯怨좎옄 븯떎.

옱猷 諛 諛⑸쾿

떎뿕룞臾

떎뿕룞臾쇱 슚李쎌궗씠뼵뒪(Daegu, Korea)뿉꽌 Sprague-Dawley怨꾨 怨듦툒諛쏆븯쑝硫, 닔而 씛伊(230~270 g)瑜 洹몃9떦 6留덈━뵫, 珥 48留덈━瑜 떎뿕뿉 궗슜븯떎. 23~24°C쓽 씪젙븳 솚寃쎌쓣 쑀吏븯硫댁꽌 12떆媛 二/빞 닚솚二쇨린濡 臾쇨낵 궗猷뚮뒗 옄쑀濡쒖씠 怨듦툒븯쑝硫, 뻾룞쟻씤 뼲븬 벑뿉 쓽븳 떎뿕 쟾 뒪듃젅뒪瑜 理쒖냼솕 븯湲 쐞빐 쑀쓽븯떎. 蹂 뿰援щ뒗 넻利앹뿰援ы븰쉶쓽 湲곗뿉 뵲씪 쑄由ъ쟻 洹쒖젙뿉 留욊쾶 吏꾪뻾븯쑝硫, 룞쓽븰援 룞臾쇱떎뿕쑄由ъ쐞썝쉶쓽쓽 떖쓽瑜 諛쏆븘 吏꾪뻾븯떎(R2016-020).

떆빟以鍮

蹂댁뒪쎇由ъ븘 異붿텧臾(蹂댁뒪쎇由ъ븘 뿴留 異붿텧遺꾨쭚; Bioprex Labs Co., Ltd., Pune Maharashtra, India) 15, 30 mg/kg (1 mL)쓽 냽룄濡 씗꽍븯뿬 寃쎄뎄濡 닾뿬븯떎. 媛 떎뿕援곗 formalin 二쇱엯援, distilled water (DW) 닾뿬 썑 5% formalin 二쇱엯援, 蹂댁뒪쎇由ъ븘 異붿텧臾(15, 30 mg/kg) 닾뿬 썑 5% formalin 二쇱엯援곗쑝濡 遺꾨쪟븯떎. 蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓣 二쇱엯븳 썑 30遺꾩씠 寃쎄낵븳 뮘 formalin쓣 닾뿬븳 吏곹썑遺꽣 넻利앺뻾쐞諛섏쓳쓣 愿李고븯떎.

븞硫대 뿼利앹꽦 넻利 紐⑤뜽

Formalin 諛섏쓳 떎뿕 Park 벑 (2011)쓽 뿰援щ 李멸퀬븯뿬 떎뿕 諛⑸쾿怨 룞씪븯寃 吏꾪뻾븯떎. 떎뿕룞臾쇱쓣 뵆씪뒪떛 넻뿉 30遺 씠긽 쟻쓳떆耳 뒪듃젅뒪瑜 理쒖냼솕 떆耳곌퀬, 뀒뒪듃 븯뒗 룞븞 臾쇨낵 궗猷뚯쓽 꽠痍⑤ 湲덊븯떎. 5% formalin쓣 떎뿕룞臾(n=6)쓽 쇊履 닔뿼遺 뵾븯뿉 二쇱엯븯뿬 븞硫대 뿼利앹꽦 넻利앹쓣 쑀諛쒗븯怨, 빟臾쇱씠 二쇱엯맂 遺쐞瑜 臾몄瑜닿굅굹 湲곷뒗 뻾쐞瑜 넻利 吏몴濡 媛꾩<븯떎. 떎뿕 愿李 떆媛꾩 5遺 떒쐞濡 45遺꾧컙 뻾쐞諛섏쓳쓣 愿李고븯떎. Formalin쑝濡 쑀룄맂 븞硫대 뿼利앹꽦 넻利앺뻾쐞諛섏쓳뿉 蹂댁뒪쎇由ъ븘媛 誘몄튂뒗 쁺뼢쓣 솗씤븯湲 쐞븯뿬 議곌뎔(n=6)怨 떎뿕援(n=6) 떎뿕룞臾쇱뿉 媛곴컖 DW 1 mL 蹂댁뒪쎇由ъ븘 1 mL瑜 寃쎄뎄 닾뿬븯怨 30遺꾩씠 寃쎄낵븳 뮘 삤瑜몄そ 븞硫대뿉 5% formalin 50 μL瑜 二쇱엯븯떎.

TMJ 뿼利앹꽦 넻利 紐⑤뜽

넻利앸컲쓳쓣 떎뿕븯湲 쟾뿉 30遺 씠긽 떎뿕슜 뵆씪뒪떛넻뿉꽌 쟻쓳떆궓 썑 吏꾪뻾븯떎. 룷瑜대쭚由 二쇱엯쓣 쐞븯뿬 뤃由ъ뿉떥젋 뒠釉 븳履 걹뿉 cannula瑜 30 gauge 二쇱궗諛붾뒛뿉 뿰寃고븯뿬 궗슜븯怨, 씠뼱吏뒗 遺쐞뿉뒗 0.25 × 8 mm 겕湲곗쓽 씤뒓由 二쇱궗湲곕 뿰寃고븯떎. 슦꽑 뿉뀒瑜 씉엯 留덉랬 썑 삤瑜몄そ 愿젅媛 궡濡 30 μL쓽 룷瑜대쭚由곗쓣 二쇱엯븯怨, 닔 珥 궡뿉 쓽떇씠 룎븘삤뒗 寃껋쓣 愿李고븯떎. 愿怨④턿쓽 썑 븯諛 寃쎄퀎硫닿낵 븯븙 怨쇰몢遺쐞瑜 珥됱뿉 쓽빐 愿젅媛뺤쓽 쐞移섎 쑀異뷀븯怨, 빐떦遺쐞뿉 二쇱궗諛붾뒛씠 愿젅궘쓣 슟怨 븯븙쓽 떯뒗 遺쐞瑜 愿젅媛 궡濡 씤吏븯떎. 蹂 떎뿕 쟾 삁鍮 떎뿕쓣 넻븯뿬 룷瑜대쭚由곌낵 룞씪븳 뼇쓽 1% evans blue dye 뿼깋젣瑜 蹂꾨룄쓽 떎뿕룞臾쇱뿉 二쇱엯븯뿬 븙愿젅媛뺤쓽 쐞移섎 슦꽑 솗씤븯떎.

넻怨꾨텇꽍

떎뿕寃곌낵뒗 IBM SPSS Statistic ver. 20.0 (IBM Co., Armonk, NY, USA)쓣 씠슜븯뿬 least significant difference 궗썑遺꾩꽍踰뺤쓣 쟻슜븳 씪썝諛곗튂 遺꾩궛遺꾩꽍쓣 븯怨 쑀쓽닔以 0.05瑜 湲곗쑝濡 븯떎, Sigmaplot 2001 (SPSS Inc., Chicago, IL, USA)쓣 씠슜븯뿬 洹몃옒봽瑜 굹궡뿀떎. 寃곌낵뒗 룊洹 ± 몴以삤李(standard error of the mean)濡 몴떆븯떎.

寃곌낵

蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 븞硫대 넻利앺뻾쐞諛섏쓳 議곗젅슚怨

뿼利앹꽦 븞硫대 넻利앹쓣 쑀諛쒗븯湲 쐞븯뿬 5% formalin쓣 二쇱엯븳 뮘 蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 넻利앺뻾쐞諛섏쓳 議곗젅슚怨쇰 Fig. 1뿉 굹궡뿀떎. 蹂댁뒪쎇由ъ븘 닾뿬 떆 1李 넻利앺뻾쐞諛섏쓳 룷瑜대쭚由 닾뿬援, 議곌뎔(veh + 룷瑜대쭚由 닾뿬援) 洹몃━怨 빟臾 二쇱엯援 媛꾩쓽 쑀쓽븳 李⑥씠媛 뾾뿀쑝굹, 2李 넻利앺뻾쐞諛섏쓳뿉꽌뒗 룷瑜대쭚由 二쇱엯援곗뿉 鍮꾪빐 빟臾 二쇱엯援(Bos 15 mg/kg, 30 mg/kg) 紐⑤몢 넻利앺뻾쐞諛섏쓳씠 냽룄 쓽議댁쟻쑝濡 쑀쓽븯寃 媛먯냼릺뿀떎(P<0.05). 떆媛꾩쓽 寃쎄낵뿉 뵲瑜 넻利앺뻾쐞諛섏쓳쓽 蹂솕瑜 Fig. 2瑜 넻빐 솗씤븯떎. Bos 15 mg/kg 닾뿬 떆뿉뒗 빟臾 二쇱엯 15~35遺 떆젏뿉꽌 슚怨쇱쟻쑝濡 넻利앺뻾쐞諛섏쓳씠 媛먯냼릺뿀怨, Bos 30 mg/kg 닾뿬援곗뿉꽌 뿭떆 2李 넻利앺뻾쐞諛섏쓳뿉 빐떦븯뒗 15~35遺 寃쎄낵떆젏뿉꽌 넻利 議곗젅뿉 슚怨쇱쟻씠뿀떎. 씠윭븳 寃곌낵瑜 넻빐 蹂댁뒪쎇由ъ븘媛 븞硫대 湲됱꽦넻利 議곗젅뿉 슚怨쇱쟻엫쓣 븣 닔 엳뿀떎.

Fig. 1.

The effect of the boswellia extract (Bos; 15, 30 mg/kg) on behavioral responses following injection of formalin (5%, 50 μL) into vibrissa pad. Bos reduced behavioral responses during the second phase compared with 5% formalin group. *P<0.05 vs. F, #P<0.05 vs. vehicle (veh)竊딣.


Fig. 2.

Time response curve for the number of scratches responses following injection of formalin (5%, 50 μL) into vibrissa pad 30 minutes after oral administration of boswellia extract (Bos). *P< 0.05 vs. F, #P<0.05, vs. vehicle (veh)竊딣.


蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 꽦愿젅 넻利앺뻾쐞諛섏쓳 議곗젅슚怨

룷瑜대쭚由곗쑝濡 쑀룄븳 븙愿젅媛뺤쑝濡 二쇱엯븳 넻利 紐⑤뜽뿉꽌 蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 넻利앹“젅슚怨쇰뒗 Fig. 3뿉 굹궡뿀떎. Formalin援곗뿉꽌 꽦愿젅 넻利앺뻾쐞諛섏쓳 398.3±24.8쉶濡 굹궗쑝硫, DW援곗뿉꽌뒗 403.0±23.5쉶濡 DW援곗뿉꽌뒗 꽦愿젅 넻利앹“젅슚怨쇨 굹굹吏 븡븯떎. 븯吏留 蹂댁뒪쎇由ъ븘 異붿텧臾(15, 30 mg/kg)쓽 寃쎄뎄 닾뿬뒗 媛 276.2±8.20, 78.3±4.7쉶濡 룷瑜대쭚由곗쑝濡 쑀룄맂 넻利앺뻾쐞諛섏쓳쓣 媛먯냼떆耳곕떎. Fig. 4뒗 뻾쐞諛섏쓳쓽 蹂솕瑜 떆媛꾩쓽 寃쎄낵뿉 뵲瑜 寃곌낵 洹몃옒봽濡, formalin쓽 닾뿬濡 씤븳 넻利앺뻾쐞諛섏쓳씠 15遺 씠썑遺꽣 利앷븯뿬 25遺꾩뿉 媛옣 넂寃 굹궗쑝硫 35遺꾧퉴吏 吏냽릺떎媛 씠썑 떎떆 媛먯냼븯떎. 蹂댁뒪쎇由ъ븘 異붿텧臾쇱쓽 寃쎄뎄 닾뿬뒗 룷瑜대쭚由 二쇱엯 25~30遺꾩뿉꽌 꽦愿젅 넻利앷꼍媛먰슚怨쇨 쑀쓽븳 寃껋쓣 솗씤븷 닔 엳뿀떎.

Fig. 3.

The effect of the boswellia extract (Bos; 15 mg/kg, 30 mg/ kg) on behavioral responses following injection of formalin (5%, 30 μL) into temporomandibular joint. Bos reduced behavioral responses during the second phase compared with 5% formalintreated group. *P<0.05 vs. F, #P<0.05 vs. vehicle (veh)竊딣.


Fig. 4.

Time response curve for the number of scratches responses following injection of formalin (5%, 30 μL) into temporomandibular joint 30 minutes after oral administration of boswellia extract (Bos). *P<0.05 vs. F, P<0.05 vs. vehicle (veh)竊딣.


怨좎같

援ш컯 븞硫대쓽 넻利 議곗젅쓣 쐞븯뿬 븘뒪뵾由, 씠遺봽濡쒗렂 벑쓽 鍮꾩뒪뀒濡쒖씠뱶꽦 냼뿼吏꾪넻젣媛 二쇰줈 泥섎갑릺뒗뜲 怨쇰떎 蹂듭슜 떆 媛꾩넀긽 諛 옣異쒗삁 벑쓽 遺옉슜씠 븣젮졇 엳怨, 쟾떊吏덊솚쓣 媛吏 솚옄뿉 븳 빟臾쇱쿂諛 떆 삉뒗 蹂듭슜以묒씤 빟怨쇱쓽 蹂묒슜뿉 뵲瑜 遺옉슜쑝濡 빀꽦쓽빟뭹쓽 쓽議댁쟻 泥섎갑뿉 븳 슦젮濡 씤븯뿬 泥쒖뿰빟臾쇱뿉 븳 愿떖쑝濡 씠뼱吏怨 엳떎(Kim et al., 2017b). 뵲씪꽌 理쒓렐뿉뒗 移섎즺젣쓽 썝泥쒖쑝濡 泥쒖뿰臾쇱쓣 씠슜븳 빟臾쇱쓽 媛쒕컻씠 媛移 엳뒗 쟾왂쑝濡 뿰援ъ옄뱾쓽 愿떖쓣 걣怨 엳떎. Kim 벑 (2017a)쓽 뿰援ъ뿉꽌 룷瑜대쭚由곗쑝濡 쑀룄븳 痢〓몢븯븙愿젅 넻利 紐⑤뜽뿉꽌 maca쓽 닾뿬媛 痢〓몢븯븙愿젅옣븷쓽 넻利 諛쒖깮怨 議곗젅뿉 슚怨쇱쟻엫쓣 솗씤븯怨, Choi 벑 (2017)쓽 뿰援ъ뿉꽌뒗 諛붿삤諛μ쓽 寃쎄뎄 닾뿬븳 寃곌낵 룷瑜대쭚由곗뿉 쓽빐 쑀諛쒕맂 븞硫대 뿼利앹꽦 넻利 떎뿕룞臾쇱뿉꽌 슚怨쇱쟻쑝濡 넻利앺뻾쐞諛섏쓳씠 媛먯냼릺뒗 寃껋쓣 利앸챸븯떎. 삉븳 Lee 벑 (2017)쓽 뿰援ъ뿉꽌 솉궪 諛 쓳궪 異붿텧臾쇱씠 媛꾧낵 떊옣뿉 遺옉슜쓣 굹궡吏 븡쑝硫댁꽌 룷瑜대쭚由곗쑝濡 쑀룄맂 븞硫대 넻利앷낵 Nrf2쓽 諛쒗쁽쓽 議곗젅뿉 슚怨쇱쟻씤 寃껋쑝濡 굹궗怨, Kim 벑 (2017)쓽 뿰援ъ뿉꽌룄 븞硫대 뵾븯 꽦愿젅 媛뺤뿉 媛곴컖 룷瑜대쭚由곗쓣 二쇱엯븯뿬 쑀諛쒗븳 몢 媛吏 넻利 紐⑤뜽뿉 뻾쐞諛섏쓳쓣 룊媛븳 寃곌낵, 궛옄굹臾 異붿텧臾쇱쓽 寃쎄뎄 닾뿬뒗 몢 紐⑤뜽뿉꽌 쑀쓽븳 넻利앷꼍媛먰슚怨쇰 굹궡뿀쓬쓣 솗씤븯떎. 뵲씪꽌 븞硫대 넻利 諛쒖깮怨 議곗젅뿉 泥쒖뿰臾 쑀옒 빟臾쇰뱾쓽 移섎즺슚怨쇰 엯利앺븯湲 쐞븯뿬 蹂 뿰援ъ뿉꽌뒗 援ш컯븞硫댁쁺뿭쓽 넻利앹쓣 떎뿕뿉 쟻슜븯湲 쐞빐 븞硫대 뵾븯 꽦愿젅 궡뿉 formalin쓣 二쇱엯븯뿬 쑀諛쒗븳 몢 넻利 紐⑤뜽뿉꽌 泥쒖뿰臾쇱씤 蹂댁뒪쎇由ъ븘 異붿텧臾쇰줈 씤븳 넻利 議곗젅뿉 븳 슚怨쇰 솗씤븯怨좎옄 븯떎.

蹂댁뒪쎇由ъ븘뒗 빆뿼利앹젣, 吏꾪넻젣, 빆愿젅뿼 諛 빆 利앹떇젣濡 씤룄 쓽빟 떆뒪뀥(Ayurvedic)뿉꽌 씪諛섏쟻쑝濡 궗슜릺뼱吏怨 엳뒗 臾쇱쭏씠떎. Gupta 벑 (2001)쓽 뿰援ъ뿉꽌뒗 留뚯꽦 옣뿼쓽 移섎즺뿉 슚怨쇱쟻 씪 닔 엳쓬쓣 諛앺깉怨, Pandey 벑 (2005)쓽 뿰援ъ뿉꽌뒗 Boswellia serrata쓽 異붿텧臾쇱 삁泥 HDL쓽 利앷 븿猿 媛뺥븳 肄쒕젅뒪뀒濡 삁利앹쓣 媛吏怨 엳뼱 솢꽦솕 맂 伊먯쓽 蹂듦컯 궡 떇꽭룷뿉 쓽븳 LPS濡 쑀룄맂 NO 깮꽦쓣 뼲젣븯怨 蹂댄샇 꽦吏덉쓣 굹굹뒗 寃껋쓣 솗씤븷 닔 엳뿀떎. 삉븳 Mohamad 벑 (2012)쓽 뿰援ъ뿉꽌룄 蹂댁뒪쎇由ъ븘 異붿텧臾쇱씠 떦눊蹂묒뿉 쁺뼢쓣 誘몄튂怨 떊옣怨 媛꾩뿉꽌 떦눊 빀蹂묒쬆쓣 삁諛⑺븷 닔 엳떎뒗 寃껋쓣 諛앺삍떎. 씠泥섎읆 蹂댁뒪쎇由ъ븘뒗 쟾諛섏쟻쑝濡 쟾떊뿉 떎뼇븳 빟由ъ쟻 슚뒫 옉슜씠 엳뒗 寃껋쓣 솗씤븷 닔 엳뿀떎. 씠瑜 湲곗큹濡 쟾떊뿉꽌 떖由ъ쟻쑝濡, 媛먭컖쟻쑝濡 誘쇨컧븳 遺쐞씤 븞硫대 넻利 셿솕뿉 蹂댁뒪쎇由ъ븘媛 誘몄튂뒗 쁺뼢쓣 솗씤븯湲 쐞빐 떎뿕쓣 吏꾪뻾븯떎.

蹂 뿰援ъ쓽 寃곌낵瑜 蹂대㈃ 蹂댁뒪쎇由ъ븘쓽 깮由ъ빟由ы븰쟻 듅꽦씠 굹궃 뿼利앹꽦 넻利 紐⑤뜽뿉꽌 븞硫대 넻利앺뻾쐞諛섏쓳씠 媛먯냼븳 寃껋쓣 솗씤븷 닔 엳뿀쑝硫, 씠뒗 룷瑜대쭚由곗쑝濡 쑀룄븳 넻利 諛 뿼利 떊샇쟾떖 寃쎈줈뿉 쁺뼢쓣 誘몄퀜 議곗젅맂 寃껋쑝濡 깮媛곷맂떎. 씠뒗 넻利 諛 뿼利 떊샇쓽 議곗젅슚怨쇰 媛吏뒗 蹂댁뒪쎇由ъ븘쓽 닾뿬濡 씤븯뿬 룷瑜대쭚由곗쑝濡 쑀룄븳 뿼利앹꽦 븞硫대 넻利 紐⑤뜽뿉꽌 떎뿕룞臾쇱쓽 넻利앺뻾쐞 諛섏쓳쓣 媛먯냼떆궎뒗 寃껋쓣 蹂댁븘 넻利앷꼍媛먰슚怨쇨 쑀쓽븳 寃껋쓣 利앸챸븯떎.

뵲씪꽌 蹂댁뒪쎇由ъ븘뒗 湲됱꽦 뿼利앹꽦 븞硫대 넻利앹뿉꽌 삁諛 諛 移섎즺 諛⑹븞뿉 엳뼱 솢슜 媛뒫븳 泥쒖뿰泥댁빟臾쇰줈 궗슜맆 닔 엳쓣 寃껋쑝濡 삁긽맂떎. 븯吏留 쟾諛섏쟻씤 븞硫대 넻利 紐⑤뜽뿉 쟻슜씠 媛뒫븳 吏瑜 뙆븙븯湲 쐞븯뿬 留뚯꽦 뿼利앹꽦 넻利 紐⑤뜽뿉꽌룄 쁺뼢쓣 誘몄튂뒗 吏뿉 븳 異붽쟻씤 뿰援ш 븘슂븷 寃껋쑝濡 궗猷뚮맂떎.

ACKNOWLEDGEMENTS

씠 끉臾몄 2012뀈룄 젙遺(誘몃옒李쎌“怨쇳븰遺)쓽 옱썝쑝濡 닔뻾맂 뿰援ъ엫(No. 2012M3A9B6055414).

CONFLICT OF INTEREST

No conflict of interests exists for any of the authors.

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