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Inhibition of 5α-reductase of de novo Generation of Short Anti-oxidant Peptides
Biomed. Sci. Lett. 2018;24:263-269
Published online September 30, 2018;  https://doi.org/10.15616/BSL.2018.24.3.263
© 2018 The Korean Society For Biomedical Laboratory Sciences.

Sung-Gyu Lee* and Hyun Kang†,*

Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan-si, Chungnam 31116, Korea
Correspondence to: Hyun Kang. Department of Medical Laboratory Science, College of Health Science, Dankook University, Cheonan-si, Chungnam, 31116, Korea.
Tel: +82-41-550-3015, Fax: +82-41-559-7934, e-mail: hkang@dankook.ac.kr
*Professor.
Received July 11, 2018; Revised September 28, 2018; Accepted October 1, 2018.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
This study aims to investigate the biological activities related to hair loss of short anti-oxidant peptides (DK peptides) 5α-reductase inhibition and anti-oxidation. The series of DK peptides were generated amphipathic helical properties using leucines, lysines and tryptophan residues. Cell viability and free radical scavenging activities were performed using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl-tetrazolium bromide (MTT) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay, respectively. The DK peptides were investigated for inhibitory activity against 5α-reductase. Antioxidant activities were determined by means of, 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assays. All peptides could inhibit 5α-reductase in lipopolysaccharide-stimulated macrophage. In conclusion, DK peptides was suggested as the most attractive ingredients for improving hair loss, because of the high inhibitory against 5α-reductase inhibition.
Keywords : 5α-reductase, Anti-oxidant peptides, Hair loss