Biomedical Science Letters

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Fig. 2. Schematic diagram of aptamer-linked liposome preparation. (A) Doxorubicin was added to liposomes and captured by proton exchange. (B) The MUC-1/CD44 aptamers were coupled with PEG-Micelles through thiol and maleimide binding reactions. (C) The aptamer conjugated micelles were mixed with a dox encapsulating liposome via the post insertion. (D) Sequence of extended MUC-1 and CD44 DNA aptamer. Linker DNA was modified with FITC and 5'- and 3'-terminal thiols, respectively.
Biomed Sci Letters 2021;27:1-11
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