Biomedical Science Letters

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Table. 2.

The association analysis results of SNPs in the PPARGC1A gene with blood pressure and hypertension in the Korean population

No. SNP Minor allele MAF Function Hypertension (controls 4,450: cases 1,968) SBP DBP




Cases Controls OR (95%CI) Add P beta ± se Add P beta ± se Add P
1 rs9790699 T 0.066 0.057 Downstream 1.21 (1.02~1.43) 0.031 0.06±0.56 0.910 0.01±0.38 0.977
2 rs2932966 C 0.075 0.088 Intron 0.80 (0.69~0.93) 4.60×10-3 -1.21±0.47 9.74×10-3 -0.94±0.32 2.98×10-3
3 rs10938963 T 0.438 0.427 Intron 1.04 (0.96~1.13) 0.354 0.22±0.26 0.397 0.27±0.18 0.125
4 rs1472095 T 0.074 0.087 Intron 0.80 (0.68~0.93) 3.59×10-3 -1.30±0.47 5.41×10-3 -0.90±0.32 4.60×10-3
5 rs3774908 G 0.217 0.214 Intron 1.03 (0.93~1.14) 0.558 -0.24±0.32 0.449 -0.29±0.22 0.178
6 rs3774907 G 0.223 0.216 Intron 1.05 (0.95~1.15) 0.367 0.58±0.31 0.061 0.41±0.21 0.053
7 rs2290604 G 0.216 0.213 Intron 1.03 (0.93~1.14) 0.539 -0.26±0.32 0.423 -0.29±0.22 0.188
8 rs6448226 C 0.488 0.487 Intron 1.02 (0.94~1.10) 0.667 0.07±0.26 0.787 -0.06±0.18 0.753
9 rs6448227 A 0.271 0.269 Intron 1.00 (0.91~1.10) 0.977 0.42±0.29 0.149 0.35±0.20 0.079
10 rs10007750 G 0.206 0.206 Intron 1.00 (0.90~1.11) 0.979 0.56±0.32 0.084 0.38±0.22 0.081
11 rs7656250 G 0.391 0.403 Intron 0.93 (0.86~1.01) 0.100 -0.44±0.27 0.096 -0.38±0.18 0.035
12 rs10212638 G 0.069 0.075 Intron 0.93 (0.79~1.09) 0.392 0.69±0.50 0.163 0.48±0.34 0.155
13 rs16874265 A 0.107 0.111 Intron 0.96 (0.84~1.10) 0.538 0.11±0.42 0.801 -0.07±0.28 0.810
14 rs17576121 G 0.026 0.021 Intron 1.09 (0.83~1.42) 0.553 0.74±0.89 0.409 0.73±0.61 0.227
15 rs2946386 G 0.391 0.389 Intron 1.01 (0.93~1.10) 0.812 -0.29±0.27 0.281 -0.28±0.18 0.129

Abbreviations: beta, regression coefficient; CI, confidence interval; MAF, minor allele frequency; OR, odds ratio; se, standard error; SNP, single nucleotide polymorphism; Controls (normotensive), SBP < 120 mmHg and DBP < 80 mmHg; Cases (hypertensive), SBP ≥ 140 mmHg and/or DBP ≥ 90 mmHg and/or antihypertensive medication. Statistically significant values (P<0.05) are indicated in bold and underline.

Biomed Sci Letters 2021;27:12-8 https://doi.org/10.15616/BSL.2021.27.1.12
© 2021 Biomed Sci Letters