Biomedical Science Letters

eISSN 2288-7415

Download original image
Fig. 3. Signaling cascades of the macrophage-independent fibrosis in the alveolar tissue. (A) The activation of the EGFR downstream by asbestos fibers leads to the increase in the level of cytokines or chemokines for the full-scale inflammation. (B) ROS generated in alveolar cells or fibroblasts by asbestos fibers damage gDNA and mtDNA, resulting in their apoptotic cell death (Abbreviations: EGFR, epidermal growth factor receptor; MAPK, mitogen-activated protein kinase; NF-κB, nuclear factor-kappa B; AP-1, activator protein-1; mtDNA, mitochondrial DNA; ROS, reactive oxygen species; TNF-α, tumor necrosis factor-α; IL, interleukin; MIP, macrophage inflammatory protein).
Biomed Sci Letters 2021;27:111-20 https://doi.org/10.15616/BSL.2021.27.3.111
© 2021 Biomed Sci Letters