Fig. 5. Effects of esculetin on collagen-induced fibrinogen binding. (A) The flow cytometry histograms on fibrinogen binding. a, Intact platelets (base); b, collagen (2.5 μg/mL); c, collagen(2.5 μg/mL) + esculetin (50 µM); d, collagen (2.5 μg/mL) + esculetin (100 µM); e, collagen (2.5 μg/mL) + esculetin (200 µM); f, collagen (2.5 μg/mL) + esculetin (300 µM) (B) Effects of esculetin on collagen-induced fibrinogen binding (%). Measurement of fibrinogen binding was described in "Materials and Methods" section. The data are expressed as the mean ± standard deviation (n=4). aP<0.05 compared with no-stimulated platelets, **P<0.001 compared with the collagen-stimulated platelets.
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