Biomedical Science Letters

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Table. 1.

T cell responses of 5 Types of COVID-19 vaccines with reported efficacy introduced in Korea

Platform Vaccine (Manufacturer) T cell responses in human
mRNA BNT162b2mRNA (BioNTech/Pfizer) Increases in IFNγ+CD4+/CD8+ T cells after booster vaccination, Predominantly IFNγ and IL-2 secretion
mRNA-1273 (Moderna) Increases in CD4+ T cells secreting TNF > IL-2 > IFNγ after booster vaccination, Low levels of CD8+ T cells activation
Viral vector ChAdOx1nCoV-19 (Univ. of Oxford & Astra-Zeneca) Peak T cell responses 14 days after first vaccination, Increase in TNF and IFNγ secretion by CD4+ T cells at day 14
Ad26.COV2.S (Janssen) Induction of CD4+/CD8+ T cells secreting IFNγ and/or IL-2 at day 14 and 28 days post vaccination
Protein subunit NVX-CoV2373 (Novavax) CD4+ T cells responses induced by 7 days after booster vaccination, Production of IFNγ, IL-2 and TNF by CD4+ T cells
Biomed Sci Letters 2022;28:211-22
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