Fig. 1. Anti-cancer effects of HDACi(SAHA) on tumor cells inhibition and apoptosis of A549 cells in 48 h.
(A) A549 cells were treated with increasing dose (1~50 μM) of SAHA (vorinostat) for 24 or 48 h. The cell viability was assessed by WST assay. (B and C) A549 cells were treated with the indicated concentration of SAHA for 48 h, then Annexin V/PI assay was performed to measure the cell apoptosis. Bar charts showed quantitative data for total apoptosis rate at each the treated group. Data are presented as mean ± SD for triplicate experiments. A; ***P<0.001 compared with the control. C; ***P<0.001 compared with the control.
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