Fig. 5. The effects of artesunate on fibrinogen binding. (A) The flow cytometry histograms on fibrinogen binding. a, Intact platelets (base); b, collagen (2.5 μg/mL); c, collagen (2.5 μg/mL) + artesunate (50 μM); d, collagen (2.5 μg/mL) + artesunate (100 μM); e, collagen (2.5 μg/mL) + artesunate (200 μM); f, collagen (2.5 μg/mL) + artesunate (300 μM). (B) Effects of artesunate on collagen-induced fibrinogen binding (%). Measurement of fibrinogen binding was described in "Materials and Methods". The results are expressed as mean ± SD (n=4). aP<0.05 compared with no-stimulated platelets, *P<0.05, **P<0.001 compared with the collagen-stimulated platelets.
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