Fig. 1. Transcription activation by enhancers.
Enhancers are cis-regulatory elements to regulate gene transcription in a long distance. Active enhancers are occupied by transcription factors and coactivators and marked by specific histone modifications such as H3K4me1 and H3K27ac. Enhancer RNA is transcribed from them. Cell/tissue-specific genes are transcriptionally activated by the enhancers.
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