Fig. 2. Mechanisms of enhancer action.
(A) A chromatin loop is formed between enhancer and promoter by extruding the intervening region, which allows direct interaction of enhancer with promoter of target gene. (B) RNA is transcribed from enhancers to promoters and histone H3K27ac is enriched between enhancers and promoters, which indicate the tracking of enhancer activity along the intervening regions. (C) Transcription condensates are formed by various week interaction among transcription factors, cofactors, and RNA Pol II. Enhancers are likely to convey target genes to transcription condensates where biomolecules for gene transcription are enriched.
© 2023 Biomed Sci Letters
