Biomedical Science Letters

eISSN 2288-7415

Table. 1.

Their chemical structures and functions in Parkinson's disease-related natural products

Molecules Structural formula Plant of origin Function References
Baicalein Scutellaria baicalensis, Scutellaria lateriflora

Attenuates dopamine depletion in the striatum

Increased dopaminergic neurons

Inhibit α-syn and α-syn oligomer formation

Reduce mitochondrial stress and apoptosis.

(Wang et al., 2005; Cheng et al., 2008; Lu et al., 2011)
Resveratrol Fruits (grape etc.)

Antioxidant and radical scavenging

Protect dopaminergic neurons

(Mudo et al., 2012)
Madecassoside Centella asiatica

Attenuates striatal dopamine decline

Increased BDNF protein expression rate

ROS reduction

Downregulation of pro-inflammatory protein expression

(Xu et al., 2013; Sasmita et al., 2018)
Berberine Berberis vulgaris, Berberis aristata etc.

Attenuates of oxidative stress, inhibition of apoptosis in hippocampus

Attenuates of dopaminergic neurodegeneration

Improvement of memory

Increase of motor balance

Neuroprotective effect

(Bae et al., 2013; Kim et al., 2014; Zhang et al., 2017)
EGCG (epigallocatechin gallate) Camelia Sinesis (Green tea)

Attenuates DA depletion in the SNpc

Survival and protection of dopaminergic neurons

Blocking the absorption of MPP+

Decreased DAT

(Levites et al., 2001; Loder and Melikian, 2003)
Ginkgolides Ginkgo biloba

Reduce behavioral disorders

Reduce oxidative stress

Protect striatum

Prevent dopamine depletion

(Kim et al., 2004; Rojas et al., 2008)

α-syn; alpha-synucelin, BDNF; brain-derived neurotrophic factor, ROS; reactive oxygen species, DA; dopamine, SNpc; substantia nigra pars compacta, MPP+; 1-methyl-4-phenylpyridinium, DAT; dopamine transpoter

Biomed Sci Letters 2023;29:121-9
© 2023 Biomed Sci Letters