Fig. 1. Effects of Der p 38 and Der f 38 on inflammatory cells in wild type (WT) and TLR4 knockout (KO) BALB/c mice.
Immunohistochemical staining was performed to detect neutrophils (Ly6G), eosinophils (eosinophil peroxidase; EPX), and mast cells (tryptase) in the lung, subsequent to Der p 38 or Der f 38 exposure in WT (A) and TLR4 KO (B) mice. The samples were examined under light microscopy (magnification, ×200). For histological evaluation of mouse lung tissues, increased numbers of neutrophils, eosinophils, and mast cells were calculated as the area of positive cells to the total cell area in the lung of WT (C) and TLR4 KO mice (D). *P < 0.05 indicates a significant difference between the Der p 38 and Der f 38 stimulated groups.
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