LNP formulations for delivering mRNA to lung
| LNPs | |||||
|---|---|---|---|---|---|
| Formulation | Lipid molar ratio (%) | ||||
| DOTAP | DOPE | DSPE-PEG2000 | PA-PEG-mannose | Cholesterol | |
| LNP1 | 50 | 49 | 1 | 0 | 0 |
| LNP2 | 50 | 29 | 1 | 0 | 20 |
| LNP2-1 | 50 | 39 | 1 | 0 | 10 |
| LNP2-2 | 50 | 19 | 1 | 0 | 30 |
| LNP3 | 40 | 40 | 10 | 10 | 0 |
| LNP3-1 | 50 | 40 | 5 | 5 | 0 |
| LNP3-2 | 50 | 48 | 0 | 2 | 0 |
