Fig. 3. Effect of p53 and MMR on amifostine-induced cell cycle arrest. HCT116 sublines were exposed to 4.8 mM amifostine for 24 h. Cells were harvested at 1, 2, 3, 4, and 5 days after the beginning of amifostine exposure. The percent of cells in G2/M, S and G1 phase was determines by flowcytometery. Data points represent mean ± SD of 3 different experiments. d0 mean amifostine untreated cells. D1 mean 24 h after the beginning of amifostine exposure.
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