Biomedical Science Letters

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Fig. 10. This figure illustrates the key steps and variable selection in the antibody-quantum dot conjugate manufacturing process. The figure visually represents the process of manufacturing conjugates by inducing the binding of amine (NH2) groups and carboxyl (COOH) groups, which serve as functional groups on the quantum dot beads, using the carbodiimide and sulfo-NHS reactions. The figure also indicates that during the conjugate manufacturing process, the quantity of Q.dots and antibodies are considered as variables and preliminary tests are conducted. The quantity of Q.dots is chosen based on DLS results, background signals, and aggregation considerations. DLS results are used to assess the size distribution and average size of quantum dots, which are adjusted to match the target size of conjugates and the size of quantum dots (Use of UV lamp).
Biomed Sci Letters 2023;29:344-54
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