Fig. 2. Cell binding affinity of aptamosome[SAHA] by anti-PD-L1 aptamer.
(A) LL/2 cells and HepG2 cells were incubated for 10 and 30 min with liposome [SAHA] and aptamosome [SAHA] at 37℃. The intercellular localization of the liposome was visualized through fluorescence microscopy with rhodamine attached to the lipids. The fluorescent images were captured at 40× magnification. DAPI (blue): nuclei, Rhodamine (red): liposomes. (B) In LL/2 cells, the binding affinities of liposome [SAHA] and aptamosome [SAHA] were analyzed using flow cytometry. Red: liposome [SAHA] 10 min, Green: liposome [SAHA] 30 min, Blue: aptamosome [SAHA] 10 min, Brown: aptamosome [SAHA] 30 min.
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