Basic distinctive of Normal and T2DM of the Korean Association REsource (KARE) cohort
| Characteristics | Quantitative trait analysis* | Case-control analysis | ||
|---|---|---|---|---|
| Normal | T2DM | |||
| Number of subjects | 6,475 | 5,721 | 754 | |
| Sex (male [%]/female [%]) | 3078(47.5)/ 3397(52.5) | 2687(47.0)/ 3034(53.0) | 391(51.9)/ 363(48.1) | 0.137 |
| Age (M ± SD years) | 51.60±8.80 | 51.16±8.68 | 54.95±9.00 | 0.104 |
| Body mass index (BMI) (M ± SD kg/m2) | 24.44±3.08 | 24.27±2.99 | 25.70±3.44 | <0.001 |
| Blood glucose (M ± SD mg/dL) | ||||
| Fasting plasma glucose | 85.38±18.90 | 81.22±6.94 | 116.92±39.71 | <0.001 |
| Plasma glucose after 60 min of OGTT | 144.52±53.75 | 131.60±35.19 | 242.55±67.37 | <0.001 |
| Plasma glucose after 120 min of OGTT | 117.48±51.04 | 103.17±20.62 | 226.05±46.21 | <0.001 |
| Blood insulin (M ± SD IU/mL) | ||||
| Fasting plasma insulin | 7.55±86 | 7.40±4.70 | 8.72±5.81 | <0.001 |
| Plasma insulin after 60 min of OGTT | 31.98±31.68 | 32.52±31.77 | 27.88±30.69 | 0.027 |
| Plasma insulin after 120 min of OGTT | 25.83±24.53 | 25.08±22.72 | 31.47±34.87 | <0.001 |
| HbA1c (%) | 5.67±0.73 | 5.50±0.33 | 6.97±1.35 | <0.001 |
*Abbreviations: M, mean value; SD, standard deviation; T2DM, type 2 diabetes mellitus; OGTT, oral glucose tolerance test, **Control (normal), Fasting plasma glucose<100 mg/dL and Plasma glucose after 120 min of OGTT<140 mg/dL; Case (T2DM), Fasting plasma glucose≥126 mg/dL or Plasma glucose after 120 min of OGTT≥200 mg/dL or HbA1c≥6.5%, ***Significant differences in characteristics between the normal and T2DM case subjects were determined by the two-tailed Student's
