Fig. 2. Association of ABO SNPs and T2DM in the Korean population. At the top of the figure, the SNPs represent the position on chromosome 9. The association of SNPs in the ABO gene and T2DM are shown in the top-sided in Korean subjects. In the figure, the plot demonstrates the statistical significance (-log10P-value) of associations of the SNPs. Using HapMap Asian population data, the recombination rates estimated are depicted by a blue line. The SNP number (rs#) with purple diamond represents the most strongly associated SNP with T2DM. In the middle of the figure, the nucleotide position is shown in the ABO gene on chromosome 9 (NCBI build 36). The bottom panel shows a Linkage disequilibrium (LD) block in the ABO gene generated by Haploview software, based on genotyping from 6,475 KARE data.
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