Fig. 2. Persistent HDM stimulation induces higher eosinophils infiltration and mucin production in old mice than those in young mice.
(A, B) Total cell counts (A) and differential counts (B) in BALF of 6 week and 12 month-aged C57BL6/J mice after i.p. (one time) and IN (three times, once per week) administration of HDM for 4 weeks with a week interval. (C) Lung tissues were separated from the mice and were stained with H&E and PAS. Magnification, 100 μm. Data are presented as the mean ± S.D. *P < 0.05 and **P < 0.01 indicate significant differences between the PBS-treated group and the HDM-treated group. ##P < 0.01 indicates a significant difference between the 6 week-aged group and the 12 month-aged groups.
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