Biomedical Science Letters

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Table. 2.

The associated SNPs in the STON1 with hyperlipidemia in the Korean Association REsource cohort

Gene Chromosome No. SNP BP Function A1 A2 MAF OR (95% CI) Additive
P-value
Case
(n = 393)
Control
(n = 8,936)
STON1 2 G1 rs6729860 48644231 Upstream C A 0.31 0.40 0.67 (0.54–0.85) 7 × 10-4
G2 SNP_A-2161077 48648613 - G A 0.36 0.45 0.72 (0.58–0.89) 3 × 10-3
G3 rs3749142 48662098 Coding A G 0.36 0.44 0.72 (0.58–0.90) 4 × 10-3
G4 SNP_A-1905545 48663377 - G A 0.36 0.44 0.72 (0.58–0.90) 4 × 10-3
I1 rs2293274 48640638 Intronic T C 0.31 0.40 0.67 (0.54–0.84) 6 × 10-4
I2 rs2293272 48641237 Intronic G A 0.31 0.40 0.67 (0.54–0.84) 6 × 10-4
I3 rs6712592 48646617 Upstream T C 0.31 0.40 0.67 (0.53–0.84) 6 × 10-4
I4 rs6741341 48646819 Upstream T A 0.31 0.40 0.67 (0.53–0.84) 6 × 10-4
I5 rs2349098 48647787 Intronic C T 0.31 0.40 0.67 (0.53–0.84) 6 × 10-4
I6 rs13025488 48649304 Upstream G T 0.37 0.45 0.73 (0.58–0.90) 4 × 10-3
I7 rs6732365 48649911 Upstream C A 0.37 0.45 0.72 (0.58–0.90) 3 × 10-3
I8 rs12990079 48651427 Intronic C T 0.37 0.44 0.72 (0.58–0.90) 4 × 10-3
I9 rs1996970 48651987 Intronic C G 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I10 rs11681276 48652209 Upstream T G 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I11 rs11681426 48652500 Upstream A G 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I12 rs6716291 48653182 Upstream G C 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I13 rs13027618 48653479 Intronic G C 0.37 0.45 0.73 (0.58–0.90) 4 × 10-3
I14 rs13034951 48654390 Intronic A G 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I15 rs11693429 48655980 Upstream G T 0.37 0.45 0.72 (0.58–0.90) 4 × 10-3
I16 rs17039250 48661300 Coding C A 0.31 0.40 0.67 (0.54–0.85) 7 × 10-4
I17 rs3828340 48661480 Coding C T 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I18 rs940389 48661656 Missense C G 0.37 0.44 0.73 (0.58–0.90) 4 × 10-3
I19 rs3749144 48662386 Coding A T 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I20 rs3749145 48662402 Missense T C 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I21 rs3792234 48663097 Coding T G 0.31 0.40 0.67 (0.53–0.84) 6 × 10-4
I22 rs3792235 48663260 Intronic C T 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I23 rs13011288 48663571 Intronic T C 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I24 rs12992755 48663621 Intronic C T 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I25 rs11680574 48664120 Intronic G A 0.36 0.44 0.72 (0.58–0.90) 3 × 10-3
I26 rs6710565 48664188 Intronic G A 0.37 0.45 0.72 (0.58–0.90) 4 × 10-3
I27 rs10495953 48665358 Intronic T C 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I28 rs4566410 48665387 Intronic C T 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I29 rs11693559 48665452 Intronic A C 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I30 rs11693691 48665568 Intronic C G 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I31 rs11678306 48665635 Intronic G T 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I32 rs13007571 48665892 Intronic C T 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2
I33 rs3792237 48666332 Intronic A G 0.38 0.45 0.75 (0.60–0.93) 1 × 10-2

The P-values lower than the significance level (P < 0.05) are indicated in bold and underlined. The SNP positions are based on the NCBI Build 36 human genome assembly.

SNP, single nucleotide polymorphism; BP, base pair; A1, minor allele; A2, major allele; MAF, minor allele frequency; OR, odds ratio; CI, confidence interval.

Biomed Sci Letters 2024;30:298-305 https://doi.org/10.15616/BSL.2024.30.4.298
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