Biomedical Science Letters

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Table. 2.

The diagnostic utility of CD4+ T cell producing IFN-γ, IL-2, TNF-α, and polyfunctional CD4+ T cells for LTBI

ICS marker AUC Cut-off Sensitivity Specificity P-value
IFN-γ 0.8462 >0.1315 76.92% 91.67% 0.0033
IL-2 0.9131 >0.1435 76.92% 91.67% 0.0005
TNF-α 0.7430 >0.1750 61.54% 91.67% 0.0471
Polyfunctional 0.9776 >0.0470 92.31% 100.00% 0.0001

IFN-γ, interferon-gamma; IL-2, interleukin-2; TNF-α, tumor necrosis factor-alpha; LTBI, latent tuberculosis infection; ICS, intracellular cytokine staining; AUC, area under the curve.

Biomed Sci Letters 2024;30:335-40 https://doi.org/10.15616/BSL.2024.30.4.335
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