The diagnostic utility of CD4+ T cell producing IFN-γ, IL-2, TNF-α, and polyfunctional CD4+ T cells for LTBI
ICS marker | AUC | Cut-off | Sensitivity | Specificity | |
---|---|---|---|---|---|
IFN-γ | 0.8462 | >0.1315 | 76.92% | 91.67% | 0.0033 |
IL-2 | 0.9131 | >0.1435 | 76.92% | 91.67% | 0.0005 |
TNF-α | 0.7430 | >0.1750 | 61.54% | 91.67% | 0.0471 |
Polyfunctional | 0.9776 | >0.0470 | 92.31% | 100.00% | 0.0001 |
IFN-γ, interferon-gamma; IL-2, interleukin-2; TNF-α, tumor necrosis factor-alpha; LTBI, latent tuberculosis infection; ICS, intracellular cytokine staining; AUC, area under the curve.