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The Relationship between Family History and Hypertension by Serum Glucose Levels and Age in Korean Men and Women
Biomed Sci Letters 2022;28:284-289
Published online December 31, 2022;  https://doi.org/10.15616/BSL.2022.28.4.284
© 2022 The Korean Society For Biomedical Laboratory Sciences.

Mikyung Ryu1,* , Il-Hoon Cho2,* * , Jae Woong Sull2,†,* * and Sun Ha Jee3,* *

1Genetic Epidemiology Research Institute, Basgenbio, Co. Seoul 04167, Korea
2Department of Biomedical Laboratory Science, College of Health Science, Eulji University, Seongnam 13135, Korea
3Department of Public Health, Yonsei University, Seoul 03722, Korea
Correspondence to: Jae Woong Sull. Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, 553 Sansungdaero, Seongnam, Gyeonggi-do 13135, Korea.
Tel: +82-31-740-7318, Fax: +82-31-740-7354, e-mail: jsull@eulji.ac.kr
*Researcher, **Professor.
Received November 1, 2022; Revised December 5, 2022; Accepted December 5, 2022.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Hypertension is associated with cardiovascular disease. The environmental and genetic factors can cause the development of hypertension. In this study, the relationship between hypertension and family history of hypertension in Koreans was analyzed in consideration of serum fasting blood glucose levels and age. The study subjects were 2,484 subjects who had a medical examination at a university hospital. The main statistical analysis method was multiple logistic regression analysis. Hypertension prevalence was 16.4% of all subjects, and subjects with a family history of hypertension were 23.5%. The risk of hypertension was 2.36 times higher in subjects with a family history of hypertension than subjects without a family history of hypertension. In addition, in the subjects with fasting blood glucose levels more than 120 mg/dL, the risk of hypertension was 4.44 times higher in subjects with a family history of hypertension compared with subjects without a family history of hypertension. The relationship between family history and hypertension was slightly higher in the older group than in the younger group. To assess the association between hypertension and family history, further cohort study is necessary in the future.
Keywords : Family history, Hypertension, Obesity, Age, Glucose levels
꽌 濡

怨좏삁븬 쟾꽭怨꾩쟻쑝濡 20%뿉꽌 30%쓽 씤援ъ뿉 쁺뼢쓣 二쇰뒗 吏덊솚씠떎(Rosner et al., 2013; Delles et al., 2010; Liang et al., 2011). 怨좏삁븬 솚寃쎌쟻 슂씤怨 쑀쟾쟻 슂씤씠 븿猿 쁺뼢쓣 誘몄튂뒗 떎씤옄꽦 吏덊솚쑝濡 蹂닿퀬맂떎. 삉븳 鍮꾨쭔, 슫룞 遺議깃낵 媛숈 깮솢뒿愿 怨좏삁븬 諛쒖깮뿉 以묒슂븳 슂씤씠떎(Zaw et al., 2011; Li et al., 2019; Ehret et al., 2010; Liu et al., 2015).

援궡쇅 뿬윭 뿰援ъ뿉꽌 怨좏삁븬 媛議깅젰씠 엳쑝硫 媛議깅젰씠 뾾뒗 궗엺뱾蹂대떎 怨좏삁븬 諛쒖깮 쐞뿕씠 2諛곗뿉꽌 4諛 젙룄 넂븘吏꾨떎怨 蹂닿퀬뻽떎(Muldoon et al., 1993; Winnicki et al., 2006; Choi et al., 2019). 븳렪, 援궡쇅 뿬윭 뿰援ъ뿉꽌 떖삁愿 吏덊솚쓽 쐞뿕쓣 넂씠뒗 二쇱슂 썝씤쑝濡 鍮꾨쭔쓣 蹂닿퀬븯떎(Jee et al., 2006; Millar et al., 2013; Tadic et al., 2016; Modesti et al., 2014). 빐쇅뿉뒗 怨좏삁븬 媛議깅젰怨 怨좏삁븬쓽 긽愿愿怨꾨 怨듬났 떆 삁떦, 굹씠 泥댁쭏웾吏닔(BMI)瑜 怨좊젮븳 뿰援ш 留롮留 援궡뿉뒗 愿젴 뿰援ш 留롮 븡떎(Li et al., 2021; Ehret et al., 2010). 뵲씪꽌 蹂 뿰援ъ뿉꽌뒗 븰蹂묒썝 嫄닿컯寃吏꾩뿉 李몄뿬븳 븳援씤 긽옄뱾뿉꽌 媛議깅젰뿉 뵲瑜 怨좏삁븬쓽 愿젴꽦쓣 븣븘蹂닿퀬옄 븯떎. 삉븳 怨듬났 떆 삁떦, 굹씠, BMI뿉 뵲씪꽌 愿젴꽦뿉 李⑥씠媛 엳뒗吏 솗씤븯怨좎옄 븯떎.

옱猷 諛 諛⑸쾿

뿰援 긽옄

뿰援 긽옄뒗 2004뀈遺꽣 2013뀈 궗씠뿉 援궡 븰蹂묒썝 嫄닿컯寃吏꾩뿉 李몄뿬븯怨 寃吏꾩쓣 諛쏆 2,484紐낆씠뿀떎(Cho et al., 2016; Sull et al., 2020). 2,484紐낆쓽 긽옄 以 16.4%쓽 긽옄媛 怨좏삁븬 솚옄怨, 23.5%쓽 긽옄媛 怨좏삁븬 媛議깅젰씠 엳뿀떎. 蹂 뿰援щ뒗 쓣吏븰援 IRB(뿰援ъ쑄由ъ떖쓽쐞썝쉶)濡쒕꽣 듅씤쓣 諛쏆븯떎(EU20-02-01).

議곗궗궡슜

뿰援 李몄뿬 긽옄뱾쓽 泥댁쨷, 떊옣, 뿀由 몮젅 벑쓽 泥댁쐞옄猷뚮 痢≪젙븯떎. 씉뿰긽깭뒗 '鍮꾪씉뿰옄', '怨쇨굅 씉뿰옄', '쁽옱 씉뿰옄'濡 굹늻뿀떎. 泥댁쨷(kg)쓣 떊옣(m)쓽 젣怨깆쑝濡 굹늻뼱꽌 泥댁쭏웾吏닔瑜 怨꾩궛븯떎. 怨듬났 썑 梨꾩랬븳 삁븸쑝濡쒕꽣 怨듬났 떆 삁떦, 吏吏 닔移 벑씠 遺꾩꽍릺뿀떎. 깮솕븰 愿젴 遺꾩꽍 Hiitachi-7600 遺꾩꽍옣鍮(Hitachi, Ltd., Tokyo, Japan)瑜 궗슜븯떎. 議곗궗맂 蹂닔뿉 븳 異붽쟻씤 꽕紐낆 씠쟾 뿰援ъ뿉꽌 湲곗닠릺뿀떎(Cho et al., 2016).

넻怨 遺꾩꽍

넻怨 遺꾩꽍 SPSS version 25.0 (IBM Corp., Armonk, NY, USA)瑜 씠슜븯떎. 넻怨꾩쟻 쑀쓽꽦 P-value 0.05 誘몃쭔쑝濡 젙쓽븯怨 뼇痢 寃젙쓣 씠슜븯떎. 룊洹 ± 몴以렪李⑤ 씠슜븯뿬 寃곌낵瑜 젣떆븯떎. 二쇱슂 넻怨 遺꾩꽍 諛⑸쾿 떎以 濡쒖뒪떛 쉶洹遺꾩꽍쓣 씠슜븯떎. 넻젣맂 샎蹂닔뒗 굹씠, 꽦蹂, 泥댁쭏웾吏닔, HDL 肄쒕젅뒪뀒濡ㅼ씠뿀떎. 怨좏삁븬뿉 븳 젙쓽뒗 닔異뺢린삁븬씠 140 mmHg 씠긽 삉뒗 씠셿湲고삁븬씠 90 mmHg 씠긽씠嫄곕굹 怨좏삁븬 빟臾 蹂듭슜젰쑝濡 젙쓽릺뿀떎. 洹몃━怨 굹씠쓽 以묒븰媛(median)씤 50꽭濡 긽옄瑜 굹늻뼱꽌 遺꾩꽍븯떎. 굹씠媛 쟾泥 긽옄쓽 긽쐞 25%뿉 빐떦븯뒗 57꽭 씠긽쓽 긽옄뿉 븳 遺꾩꽍룄 븯떎. 삉븳 泥댁쭏웾吏닔룄 以묒븰媛 23.98 kg/m2쑝濡 긽옄瑜 굹늻뼱꽌 遺꾩꽍븯떎. 怨듬났 떆 삁떦쓽 寃쎌슦룄 以묒븰媛믪뿉 빐떦븯뒗 91 mg/dL瑜 湲곗쑝濡 긽옄瑜 굹늻뼱꽌 遺꾩꽍븯떎. 븳렪 怨듬났 떆 삁떦 긽쐞 6%뿉 빐떦븯뒗 120 mg/dL濡쒕룄 긽옄瑜 援щ텇븯뿬 遺꾩꽍븳 寃곌낵瑜 젣떆븯떎.

寃 怨

蹂 뿰援ъ뿉 李몄뿬븳 긽옄쓽 룊洹 굹씠뒗 궓옄媛 50꽭, 뿬옄媛 50.7꽭씠뿀떎. 泥댁쭏웾吏닔뒗 궓옄쓽 룊洹좎씠 24.7, 뿬옄媛 22.9 kg/m2濡 궓옄媛 뜑 넂븯떎. 怨듬났 떆 삁떦 궓옄媛 96.7 mg/dL, 뿬옄媛 90.6 mg/dL濡 궓옄媛 뜑 넂븯떎. 뿰援 긽옄 以 궓옄쓽 씉뿰쑉 怨쇨굅 씉뿰옄뒗 37.6%, 쁽옱씉뿰옄뒗 41.2% 씠뿀떎. 삉븳 蹂 뿰援ъ쓽 긽옄뿉꽌 怨좏삁븬 쑀蹂 솚옄뒗 16.4%씠뿀怨, 怨좏삁븬 媛議깅젰씠 엳뒗 긽옄뒗 23.5%씠뿀떎(Table 1).

General characteristics of the study population

All subjects
(n = 2,484)
Men
(n = 1,608)
Women
(n = 876)
Mean ± SD Mean ± SD Mean ± SD
Age, year 50.2±9.4 50.0±9.5 50.7±9.1
Weight, kg 66.7±11.3 71.9±9.5 57.2±7.3
Waist circumference, cm 82.1±9.0 86.2±7.3 76.9±8.2
Body mass index, kg/m2 24.1±2.9 24.7±2.7 22.9±2.9
Fasting blood sugar, mg/Dl 94.6±19.7 96.7±21.2 90.6±16.0
Systolic blood pressure, mmHg 119.4±13.3 121.3±12.8 115.9±13.7
Diastolic blood pressure, mmHg 78.7±10.7 80.9±10.4 74.6±10.2
HDL-C, mg/dL 52.0±12.3 48.8±10.8 57.8±12.8
LDL-C, mg/dL 119.2±30.1 120.5±29.4 116.8±31.2
Triglycerides, mg/dL 134.8±82.5 151.8±90.2 103.5±53.4
% % %
Smoking status Ex 25.2 37.6 2.0
Current 28.2 41.2 4.0
Hypertension* 16.4 18.4 12.9
Family history of hypertension 23.5 21.5 27.3

Abbreviations: SD, standard deviation; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol

*Hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or medication



怨좏삁븬 媛議깅젰쓽 쑀臾댁뿉 뵲瑜 怨좏삁븬怨쇱쓽 愿젴꽦 遺꾩꽍뿉꽌 굹씠, 꽦蹂, HDL 肄쒕젅뒪뀒濡, 泥댁쭏웾吏닔 벑쓣 넻젣븯떎(Table 2). 怨좏삁븬 媛議깅젰씠 엳뒗 긽옄媛 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.36諛 넂 怨좏삁븬쓽 쐞뿕씠 솗씤릺뿀떎(OR, 2.36; 95%CI, 1.83~3.05). 삉븳, 궓옄 뿬옄濡 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣뿉룄 洹 寃곌낵뒗 겙 李⑥씠媛 뾾뿀떎.

Odds ratios (OR) of the family history for hypertension in the population (n = 2,484)

Subjects FHH Normal Hypertension*
Model 1 Model 2
N (%) N (%) OR (95% CI) P-value OR (95% CI) P-value
All Healthy (n = 2,484) No 1,627 (78.4) 273 (66.9) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 449 (21.6) 135 (33.1) 2.30 (1.80~2.95) 2.36 (1.83~3.05)
Men (n = 1,608) No 1,062 (80.9) 201 (68.1) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 251 (19.1) 94 (31.9) 2.39 (1.78~3.22) 2.37 (1.75~3.20)
Women (n = 876) No 565 (74.1) 72 (63.7) 1.00 (reference) 0.001 1.00 (reference) <0.001
Yes 198 (26.0) 41 (36.3) 2.13 (1.36~3.34) 2.36 (1.49~3.76)

Model 1: Adjusted for age and sex, Model 2: Adjusted for age, sex, HDL cholesterol, and body mass index

*Hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or medication

Abbreviations: OR, odds ratio; CI, confidence interval; FHH, family history of hypertension



泥댁쭏웾吏닔, 怨듬났떆 삁떦怨 굹씠쓽 以묒븰媛믪쓣 湲곗쑝濡 뿰援 李몄뿬 긽옄瑜 굹늻뼱꽌 怨좏삁븬 媛議깅젰쓽 쑀臾댁뿉 뵲瑜 怨좏삁븬怨쇱쓽 愿젴꽦 遺꾩꽍뿉꽌 굹씠, 꽦蹂, HDL 肄쒕젅뒪뀒濡, 泥댁쭏웾吏닔 벑쓣 넻젣븯떎(Table 3). 泥댁쭏웾吏닔媛 以묒븰媛 蹂대떎 궙 긽옄뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 2.15諛 넂 怨좏삁븬 쐞뿕씠 엳뿀怨(OR, 2.15; 95%CI, 1.40~3.28), 泥댁쭏웾吏닔媛 以묒븰媛 씠긽씤 援곗뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 2.34諛 넂 怨좏삁븬 쐞뿕씠 엳뿀떎(OR, 2.34; 95%CI, 1.71~3.20). 利, 泥댁쭏웾吏닔쓽 以묒븰媛믪쑝濡 뿰援 긽옄瑜 援щ텇븯쓣 븣 怨좏삁븬 媛議깅젰怨 怨좏삁븬怨쇱쓽 愿젴꽦뿉꽌 겙 李⑥씠뒗 뾾뿀떎.

Odds ratios (OR) of the family history for hypertension in strata of median BMI, median age, and median fasting blood sugar in Korean population (n = 2,484)

Subjects FHH Normal Hypertension*
N (%) N (%) ORa (95% CI) P-value
BMI<23.98 No 866 (77.8) 90 (69.2) 1.00 (reference)
Yes 247 (22.2) 40 (30.8) 2.15 (1.40~3.28) <0.001
BMI>=23.98 No 761 (79.0) 183 (65.8) 1.00 (reference)
Yes 202 (21.0) 95 (34.2) 2.34 (1.71~3.20) <0.001
FBS<91 No 816 (76.1) 92 (64.3) 1.00 (reference)
Yes 257 (23.9) 51 (35.7) 2.28 (1.54~3.39) <0.001
FBS>=91 No 811 (80.9) 181 (68.3) 1.00 (reference)
Yes 192 (19.1) 84 (31.7) 2.44 (1.76~3.37) <0.001
FBS>=120 No 90 (86.5) 32 (66.7) 1.00 (reference)
Yes 16 (13.5) 16 (33.3) 4.44 (1.81~10.9) 0.001
Age<50 No 849 (75.1) 63 (62.4) 1.00 (reference)
Yes 281 (24.9) 38 (37.6) 1.93 (1.25~2.97) <0.001
Age>=50 No 778 (82.2) 210 (68.4) 1.00 (reference)
Yes 168 (17.8) 97 (31.6) 2.55 (1.88~3.46) <0.001
Age>=57 No 367 (86.2) 128 (69.2) 1.00 (reference)
Yes 59 (13.9) 57 (30.8) 3.25 (2.11~5.01) <0.001

aAdjusted for age and sex

*Hypertension was defined as systolic blood pressure ≥140 mmHg or diastolic blood pressure ≥90 mmHg, or medication



삉븳, 怨듬났 떆 삁떦씠 以묒븰媛 씠븯쓽 援곗뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 2.28諛 넂 怨좏삁븬 쐞뿕씠 엳뿀怨(OR, 2.28; 95%CI, 1.54~3.39), 怨듬났 떆 삁떦 以묒븰媛 씠긽씤 援곗뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 2.44諛 넂 怨좏삁븬쓽 쐞뿕씠 엳뿀떎(OR, 2.44; 95%CI, 1.76~3.50). 利, 怨듬났 떆 삁떦쓽 以묒븰媛믪쑝濡 뿰援 李몄뿬 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 怨좏삁븬 媛議깅젰怨 怨좏삁븬怨쇱쓽 愿젴꽦뿉꽌 겙 李⑥씠媛 뾾뿀떎. 異붽쟻쑝濡 怨듬났 떆 삁떦씠 120 mg/dL 씠긽씤 긽옄留 蹂꾨룄濡 遺꾩꽍뻽쓣 븣뿉뒗 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 4.44諛 넂 怨좏삁븬쓽 쐞뿕씠 엳뿀떎(OR, 4.44; 95%CI, 1.81~10.9).

삉븳, 굹씠媛 以묒븰媛 蹂대떎 궙 긽옄뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 1.93諛 넂 怨좏삁븬 쐞뿕씠 엳뿀怨(OR, 1.93; 95%CI, 1.25~2.97), 굹씠媛 以묒븰媛 씠긽씤 긽옄뿉꽌 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 2.55諛 넂 怨좏삁븬쓽 쐞뿕씠 엳뿀떎(OR, 2.55; 95%CI, 1.88~3.46). 利, 怨좏삁븬 媛議깅젰怨 怨좏삁븬怨쇱쓽 愿젴꽦 怨좊졊 援곗뿉꽌 젇 援곕낫떎 愿젴꽦씠 빟媛 뜑 넂븯떎.

異붽쟻쑝濡 굹씠媛 긽쐞 25%뿉 냽븯뒗 57꽭 씠긽씤 긽옄留 蹂꾨룄濡 遺꾩꽍뻽쓣 븣뿉뒗 怨좏삁븬 媛議깅젰씠 엳뒗 援곗 媛議깅젰씠 뾾뒗 援곌낵 鍮꾧탳븯뿬꽌 3.25諛 넂 怨좏삁븬쓽 쐞뿕씠 솗씤릺뿀떎(OR, 3.25; 95%CI, 2.11~5.01).

怨 李

蹂 뿰援ъ뿉꽌뒗 븳 븰蹂묒썝뿉꽌 嫄닿컯寃吏꾩쓣 諛쏆 2,484紐낆쓽 븳援씤 궓꽦, 뿬꽦쓣 긽쑝濡 뿰졊蹂, 怨듬났 떆 삁떦 蹂, BMI 蹂꾨줈 怨좏삁븬 媛議깅젰뿉 뵲瑜 怨좏삁븬쓽 愿젴꽦쓣 遺꾩꽍븯떎. 援궡쇅 꽑뻾 뿰援щ뱾뿉꽌룄 怨좏삁븬怨 怨좏삁븬 媛議깅젰쓽 愿젴꽦쓣 蹂닿퀬븯떎. 以묎뎅 긽븯씠쓽 怨좏삁븬 솚옄 342紐, 젙긽 議곌뎔 342紐낆쓣 鍮꾧탳븳 솚옄 議곌뎔 뿰援ъ뿉꽌 怨좏삁븬 媛議깅젰 援먯감鍮 4.1濡 넻怨꾩쟻쑝濡 쑀쓽븳 媛뺥븳 愿젴꽦쓣 蹂닿퀬뻽떎(Li et al., 2019). 2014뀈뿉꽌 2016뀈뿉 슦由щ굹씪 援誘쇨굔媛뺤쁺뼇議곗궗뿉 李몄뿬븯뿬 寃吏꾩“궗, 쁺뼇議곗궗瑜 諛쏆 8,280紐낆쓣 긽쑝濡 遺꾩꽍븳 뿰援ъ뿉꽌뒗 怨좏삁븬 媛議깅젰씠 엳뒗 援곗씠 媛議깅젰씠 뾾뒗 援곕낫떎 怨좏삁븬 쑀蹂묐쪧쓽 쐞뿕씠 2.47諛 넂븯怨 넻怨꾩쟻쑝濡 留ㅼ슦 쑀쓽븳 愿젴꽦쓣 蹂댁떎(Choi et al., 2019). 븳렪 以묎뎅 遺곴꼍 吏뿭쓽 以묐뀈 궓꽦, 뿬꽦쓣 긽쑝濡 븳 떒硫 뿰援ъ뿉꽌룄 怨좏삁븬 媛議깅젰怨 怨좏삁븬 쑀蹂묐쪧怨 넂 愿젴꽦쑝濡 蹂닿퀬뻽떎. 遺紐⑤떂씠 怨좏삁븬 솚옄뜕 寃쎌슦뒗 援먯감鍮 2.15諛곕 蹂닿퀬뻽怨, 삎젣 · 옄留ㅺ 怨좏삁븬 솚옄씤 媛議깅젰 寃쎌슦뿉뒗 1.68諛곕 蹂댁쑝硫, 遺紐⑤떂怨 삎젣 · 옄留 뼇履쎌씠 솚옄씤 媛議깅젰 寃쎌슦뿉뒗 援먯감鍮꾨 3.72諛곌퉴吏 솗씤븯떎(Liu et al., 2015).

씠踰 븳援씤 긽 뿰援ъ뿉꽌뒗 怨좏삁븬 媛議깅젰怨 怨좏삁븬怨쇱쓽 넂 愿젴꽦쓣 솗씤븯떎. 삉븳 怨듬났 떆 삁떦쑝濡 뿰援 긽옄瑜 굹늻뼱꽌 遺꾩꽍븯쓣 븣 삁떦씠 넂 긽옄뿉꽌 洹 愿젴꽦씠 뜑 넂븯떎. 理쒓렐뿉 以묎뎅씤쓣 긽쑝濡 븳 怨좏삁븬 솚옄-議곌뎔 뿰援ъ뿉꽌 떦눊蹂 媛議깅젰씠 엳쑝硫 怨좏삁븬 쐞뿕씠 4.1諛 넂븘吏먯쓣 蹂닿퀬뻽떎. 삉븳 媛議깅젰怨 떦눊蹂묒씠 븿猿 엳뒗 긽옄뿉꽌뒗 媛議깅젰씠 뾾怨 떦눊蹂묒씠 뾾뒗 긽옄뿉 鍮꾪븯뿬 援먯감鍮꾨 16.5源뚯 蹂닿퀬븯떎(Li et al., 2021).

삉븳, 蹂 뿰援ъ뿉꽌뒗 怨좊졊 긽옄뿉꽌 媛議깅젰怨 怨좏삁븬쓽 愿젴꽦씠 젇 援곗뿉꽌 蹂대떎 뜑 넂븯떎. 以묎뎅씤 뿰援ъ뿉꽌 以묐뀈 긽옄쓽 媛議깅젰怨 怨좏삁븬쓽 넂 愿젴꽦쓣 蹂닿퀬뻽떎(Liu et al., 2015). 諛섎㈃뿉, 理쒓렐 젇 꽦씤쓣 긽쑝濡 븳 뿰援щ뱾쓣 醫낇빀븯뿬 遺꾩꽍븳 뿰援ъ뿉꽌뒗 媛議깅젰怨 怨좏삁븬怨쇱쓽 愿젴꽦씠 쟻쓬쓣 솗씤뻽떎(Queiroz et al., 2022). 븳렪, 以묎뎅쓽 泥냼뀈쓣 긽쑝濡 븳 뿰援ъ뿉꽌 젙긽 泥댁쨷援곗뿉꽌뒗 怨좏삁븬 媛議깅젰씠 엳뒗 援곗뿉꽌 怨좏삁븬뿉 븳 2.12諛곗쓽 援먯감鍮꾩쓽 넻怨꾩쟻쑝濡 쑀쓽븳 愿젴꽦쓣 蹂닿퀬븳 諛섎㈃ 怨쇱껜以 諛 鍮꾨쭔援곗뿉꽌뒗 1.05諛곗쓽 援먯감鍮꾨줈 넻怨꾩쟻쑝濡 愿젴꽦씠 뾾쓬쓣 蹂닿퀬뻽떎(Zhao et al., 2021).

븳렪, 媛議깅젰怨 怨좏삁븬쓽 愿젴꽦씠 긽옄쓽 鍮꾨쭔 뿬遺뿉 겕寃 쁺뼢쓣 諛쏅뒗떎뒗 뿰援щ룄 엳뿀떎. 以묎뎅 긽븯씠쓽 怨좏삁븬 솚옄 342紐, 젙긽 議곌뎔 342紐낆쓣 鍮꾧탳븳 솚옄 議곌뎔 뿰援ъ뿉꽌뒗 鍮꾨쭔怨 怨좏삁븬 媛議깅젰쓽 긽샇옉슜쓣 蹂댁븯떎. 鍮꾨쭔怨 怨좏삁븬 媛議깅젰씠 븿猿 엳뒗 援곗뿉꽌뒗 怨좏삁븬쓽 援먯감鍮꾧 媛議깅젰씠 뾾怨 젙긽泥댁쨷씤 援곌낵 鍮꾧탳뻽쓣 븣 12.9濡 넻怨꾩쟻쑝濡 留ㅼ슦 쑀쓽븳 媛뺥븳 愿젴꽦쓣 蹂댁怨, 긽샇옉슜룄 솗씤뻽떎(Li et al., 2019). 洹몃윭굹 蹂 븳援씤 긽뿰援ъ뿉꽌뒗 泥댁쭏웾吏닔뿉 뵲씪꽌 긽옄瑜 援щ텇븯뿬 遺꾩꽍뻽쓣 븣뒗 寃곌낵뿉 겙 李⑥씠媛 뾾뿀떎.

蹂 뿰援щ뒗 떒硫 뿰援ъ쓽 븳怨꾩젏쓣 媛吏怨 엳떎. 蹂 뿰援 긽옄 以 16.4%媛 怨좏삁븬 솚옄떎. 씠뒗 2014뀈뿉꽌 2016뀈뿉 슦由щ굹씪 援誘쇨굔媛뺤쁺뼇議곗궗뿉 李몄뿬븳 긽옄뿉꽌 怨좏삁븬 媛議깅젰씠 뾾뒗 긽옄쓽 怨좏삁븬 쑀蹂묐쪧 13.3%씠뿀뜕 寃껉낵 鍮꾧탳븷 븣 李⑥씠媛 겕吏 븡븯떎(Choi et al., 2019). 蹂 뿰援ъ쓽 寃곌낵뒗 삁떦씠 넂 援곌낵 怨좊졊옄뿉꽌 媛議깅젰씠 怨좏삁븬 諛쒖깮 쐞뿕怨 愿젴꽦씠 넂쓬쓣 蹂닿퀬븳 寃껋뿉 쓽쓽媛 엳떎. 씠뿉 븯뿬뒗 洹쒕え쓽 肄뷀샇듃 벑쑝濡 異붽쟻씤 寃利앹씠 븘슂븯寃좊떎. 삉븳 怨듬났 떆 삁떦 씠쇅뿉 삁깋냼, 쟻삁援 슜쟻瑜좎뿉 뵲瑜 媛議깅젰怨 怨좏삁븬怨쇱쓽 愿젴꽦뿉 븳 異붽 遺꾩꽍룄 븘슂븯寃좊떎.

ACKNOWLEDGEMENT

This paper was funded by the Korea medical institute (KMI) in 2021.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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