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The PGC-II Polymorphism of the Peroxisome Proliferator-activated Receptor γ Coactivator 1α (PGC-1α) Gene in Korean Subjects with the Metabolic Syndrome


J. Exp. Biomed. Sci. 2012;18:139-145
Published online June 30, 2012
© 2012 The Korean Society For Biomedical Laboratory Sciences.

Sun Ok Im1, In Sik Kim2, Sang Sun Kang3 and Sung-hee Hyun2,†

1Chungmu Hospital, Cheonan 373-809, Korea,
2Department of Biomedical Laboratory Science,
School of Medicine Eulji University, Daejeon 301-746, Korea, and
3Department of Biology Education
Chungbuk National University, Cheongju, Chungbuk 361-763, Korea


Correspondence to:

Sunghee Hyun.

Department of Biomedical Laboratory Science Eulji University, School of Medicine #143-5, Yongdu-dong, Jung-gu, Daejeon 301-746, Korea.
Tel: +82-42-259-1751, Fax: +82-42-259-1759

Received December 19, 2011; Revised June 3, 2012; Accepted June 4, 2012.

RFLP of PGC-1α gene of 285 Korean women was analyzed by PCR and HpaII restriction. We evaluated the correlation between PGC 1 genotypes and biochemical results, using the results of RFLP. Study subjects were divided into 3 groups: normal group (who has been average value of serum biochemical analysis), upper group (who has been higher value than average value), and low group (who have been lower value than average value). The frequencies of H1H1, H1H2, and H2H2 genotypes were 92 (32%), 85 (32%), and 108 (38%) respectively, and the ratio between H1 and H2 alleles was 1:1.1. There were no meaningful differences between biochemical results and PGC-1α genotypes in the normal group. But, in upper group, there was significant difference in total cholesterol (P=0.04) level. In the result of Turkey multiple comparison test, the P value of H1H1 and H2H2 was 0.059. In upper group, there were noticeable differences also in triglyceride (P=0.034) level and glucose (P=0.043) level, respectively. There were important differences between H1H1 type and H1H2 type in triglyceride (P=0.029) level and between H1H2 type and H2H2 type in glucose (P=0.040) level. This study may provide the PGC-1α genotype patterns for the amounts of lipid and glucose in the serum. H2 allele (Ser482) of PGC-1α gene may be related with upper group in Korean women.

Keywords :

HpaII, Meta