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The Relationship between Family History of Diabetes and Diabetes by BMI and Age in Korean Men and Women
Biomed Sci Letters 2021;27:317-322
Published online December 31, 2021;  https://doi.org/10.15616/BSL.2021.27.4.317
© 2021 The Korean Society For Biomedical Laboratory Sciences.

Eunna Ko* and Jae Woong Sull†,**

Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, Seongnam, Gyeonggi-do 13135, Korea
Correspondence to: *Researcher, **Professor.
Corresponding author: Jae Woong Sull. Department of Biomedical Laboratory Science, College of Health Sciences, Eulji University, 553 Sansungdaero, Seongnam, Gyeonggi-do 13135, Korea.
Tel: +82-31-740-7318, Fax: +82-31-740-7354, e-mail: jsull@eulji.ac.kr
Received December 20, 2021; Revised December 28, 2021; Accepted December 28, 2021.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
Diabetes is mainly evaluated by fasting blood sugar. The genetic and environmental factors influence the development of type 2 diabetes. In this study, the relationship between diabetes and family history of diabetes in Koreans was analyzed in consideration of body mass index and age. The study subjects were 4,274 subjects who received a medical examination at a university hospital. The main statistical analysis method was multiple logistic regression analysis. In addition, subjects were analyzed by dividing them by gender and the median of age and body mass index. Diabetes prevalence was 8.9% of all subjects, and subjects with a family history of diabetes were 14.5%. The risk of diabetes was 2.80 times higher in subjects with a family history of diabetes than subjects without a family history of diabetes. In addition, in younger subjects, the risk of diabetes was 3.36 times higher in subjects with a family history of diabetes compared with subjects without a family history of diabetes. In this study, the family history of diabetes was significantly associated with diabetes. The relationship between family history of diabetes and diabetes was slightly higher in the younger group than in the older group. In order to obtain an accurate assessment of the association between diabetes and family history of diabetes, further prospective cohort study in the future is necessary.
Keywords : Family history, Diabetes, Obesity, Age
꽌 濡

떦눊蹂묒 二쇰줈 怨듬났 떆 삁떦쑝濡 룊媛맂떎(Ogata et al., 2018). 떦눊蹂묒 援궡쇅뿉꽌 利앷븯怨 엳떎(Unwin et al., 2011; KCDC, 2012). 2010뀈 븳援쓽 援誘쇨굔媛뺤쁺뼇議곗궗 옄猷뚯뿉꽌 떦눊蹂 媛議깅젰 怨듬났삁떦 쇅뿉룄 뿀由щ몮젅, 以묒꽦吏諛⑷낵 媛숈 궗利앺썑援곗쓽 슂냼뱾룄 利앷떆궎뒗 寃껋쑝濡 蹂닿퀬븯떎(Park et al., 2013).

젣2삎 떦눊蹂묒쓽 諛쒖깮뿉뒗 쑀쟾쟻 슂씤怨 솚寃쎌쟻 슂씤씠 쁺뼢쓣 誘몄튂뒗 寃껋쑝濡 蹂닿퀬릺뿀떎(Kaprio et al., 1992). 젣2삎 떦눊蹂 솚옄쓽 媛議깅젰씠 엳뒗 긽옄뱾 媛議깅젰씠 뾾뒗 긽옄뱾뿉 鍮꾪븯뿬 怨좏삁떦씠 깮湲 쐞뿕씠 3諛 젙룄 넂븯떎(Shaw et al., 1999; Weijnen et al., 2002). 븳렪 理쒓렐 넚誘쇨퇋 벑뿉 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰쓣 媛뽮퀬 엳뒗 긽옄뱾씠 怨좏삁븬, 씠긽吏吏덊삁利, 뿀삁꽦 떖옣吏덊솚 媛議깅젰쓣 룞떆뿉 媛뽮퀬 엳뒗 寃쎌슦媛 떦눊蹂 媛議깅젰쓣 媛뽮퀬 엳吏 븡뒗 긽옄뱾뿉 鍮꾪빐 넂븯吏留 뇤議몄쨷 媛議깅젰 쑀쓽븳 李⑥씠瑜 蹂댁씠吏 븡븯떎(Song et al., 2017).

븳렪, 븳援씤 긽 뿰援ъ뿉꽌 鍮꾨쭔 떖삁愿吏덊솚쓽 쐞뿕쓣 넂엫쓣 蹂닿퀬븯떎(Jee et al., 2006). 빐쇅뿉뒗 떦눊蹂 媛議깅젰怨 떦눊蹂묒쓽 긽愿愿怨꾨 뿰졊怨 泥댁쭏웾吏닔(BMI)瑜 怨좊젮븯뿬 떎猷 뿰援ш 엳吏留 援궡뿉뒗 떦눊蹂묒뿉 븳 떦눊蹂 媛議깅젰쓽 긽愿愿怨꾨 뿰졊怨 BMI瑜 怨좊젮븳 뿰援ш 留롮 븡떎. 씠뿉 蹂 뿰援ъ뿉꽌뒗 援궡 븰蹂묒썝뿉꽌 嫄닿컯寃吏꾩뿉 李몄뿬븳 긽옄뱾뿉꽌 떦눊蹂 媛議깅젰뿉 뵲씪 뿰졊, BMI뿉 뵲瑜 떦눊蹂묒쓽 愿젴꽦쓣 븣븘蹂닿퀬옄 븯떎.

옱猷 諛 諛⑸쾿

뿰援 긽옄

븳 븰蹂묒썝 嫄닿컯寃吏꾩꽱꽣뿉꽌 寃吏꾩쓣 諛쏆 4,294紐낆씠 뿰援 긽옄씠뿀떎(Cho et al., 2016; Sull et al., 2020). 씠뱾뿉 빐꽌뒗 2004뀈遺꽣 2013뀈 궗씠뿉 븳援씤 븫 삁諛⑹뿰援ъ궗뾽(KCPS) 뿰援щ 쐞븯뿬 DNA 깦뵆씠 뼸뼱議뚮떎(Jee et al., 2018). 씠뱾 4,294紐 以묒뿉꽌 1,810紐낆 떖삁愿吏덊솚 솚옄떎. 떖삁愿吏덊솚뿉 븳 젙蹂대뒗 援誘쇨굔媛뺣낫뿕怨듬떒 옄猷 援젣吏덈퀝遺꾨쪟湲고샇(10뙋)쓽 ICD 肄붾뱶 I00-I99濡 솗씤릺뿀떎. 怨듬났 떆 삁떦怨 泥댁쭏웾吏닔쓽 寃곗륫媛믪씠 엳뒗 긽옄뒗 遺꾩꽍뿉꽌 젣쇅븯떎. 뵲씪꽌 理쒖쥌 뿰援 긽옄뒗 4,274紐낆씠뿀떎. 씠뱾 以 1,790紐낆 떖삁愿吏덊솚 솚옄怨, 2,484紐낆 嫄닿컯븳 긽옄떎. 뿬湲곗꽌 嫄닿컯븳 긽옄뒗 떖삁愿吏덊솚씠 뾾뒗 궗엺쑝濡 젙쓽릺뿀떎. 1,790紐 떖삁愿吏덊솚 솚옄 以 221紐낆씠 떦눊蹂 솚옄怨, 203紐낆씠 떦눊蹂 媛議깅젰씠 엳뿀떎. 2,484紐 嫄닿컯븳 긽옄 以 161紐낆씠 떦눊蹂 솚옄怨, 417紐낆씠 떦눊蹂 媛議깅젰씠 엳뿀떎. 쟾泥 4,274紐 긽옄 以묒뿉꽌 382紐낆씠 떦눊蹂 솚옄떎. 삉븳 620紐낆씠 떦눊蹂 媛議깅젰씠 엳뿀떎. 蹂 뿰援щ뒗 쓣吏븰援 IRB(뿰援ъ쑄由ъ떖쓽쐞썝쉶)濡쒕꽣 듅씤 諛쏄퀬 떆뻾릺뿀떎(EU20-02-01).

議곗궗궡슜

泥댁쐞옄猷뚮뒗 寃吏꾩“궗옄猷 以묒뿉꽌 泥댁쨷, 떊옣쓣 씠슜븯떎. 씉뿰긽깭뒗 '鍮꾪씉뿰옄', '怨쇨굅 씉뿰옄', '쁽옱 씉뿰옄'濡 굹늻뿀떎. 넻怨꾨텇꽍뿉 씠슜맂 蹂닔濡 泥댁쭏웾吏닔, 뿰졊 벑쓣 遺꾩꽍븯떎. 泥댁쭏웾吏닔뒗 泥댁쨷(kg)쓣 떊옣(m)쓽 젣怨깆쑝濡 굹늻뼱 怨꾩궛븯떎. 怨듬났 썑 梨꾩랬븳 삁븸쑝濡쒕꽣 怨듬났 떆 삁떦, 吏吏 닔移 벑씠 遺꾩꽍릺뿀떎. 遺꾩꽍 Hiitachi-7600 遺꾩꽍湲(Hitachi, Ltd., Tokyo, Japan)瑜 씠슜븯떎. 긽꽭븳 몴쁽삎뿉 븳 湲곗닠 씠쟾 뿰援ъ뿉꽌 湲곗닠릺뿀떎(Cho et al., 2016; Jee et al., 2018).

넻怨꾨텇꽍

넻怨 봽濡쒓렇옩 SPSS version 25.0 (IBM Corp., Armonk, NY, USA)瑜 씠슜븯怨 P-value 0.05 誘몃쭔쓣 넻怨꾩쟻쑝濡 쑀쓽븳 寃껋쑝濡 젙쓽븯怨 뼇痢 寃젙쓣 궗슜븯떎. 遺꾩꽍 寃곌낵뒗 二쇰줈 룊洹 ± 몴以렪李⑤줈 湲곗닠릺뿀떎. 二쇱슂 넻怨꾨텇꽍 諛⑸쾿 떎以 濡쒖뒪떛 쉶洹遺꾩꽍쓣 씠슜븯떎. 넻젣맂 샎蹂닔뒗 뿰졊, 꽦蹂, 닔異뺢린삁븬, HDL 肄쒕젅뒪뀒濡, 泥댁쭏웾吏닔떎. 떦눊蹂묒뿉 븳 젙쓽뒗 怨듬났 떆 삁떦씠 126 mg/dL 씠긽 삉뒗 떦눊蹂 빟臾 蹂듭슜젰쑝濡 젙쓽릺뿀떎. 洹몃━怨 쟾泥 吏묐떒뿉꽌쓽 紐⑤뱺 뿰졊쓽 湲곗 以묒븰媛(median)씤 52꽭濡 젙쓽븯뿬 遺꾩꽍븯떎. 삉븳 泥댁쭏웾吏닔룄 以묒븰媛 24.33쑝濡 긽옄瑜 굹늻뼱꽌 遺꾩꽍븯떎.

寃 怨

蹂 뿰援 긽옄쓽 룊洹 뿰졊 궓꽦씠 51.9꽭, 뿬꽦씠 52.8꽭씠뿀떎. 泥댁쭏웾吏닔뒗 궓꽦쓽 룊洹좎씠 24.8, 뿬꽦씠 23.5濡 궓꽦씠 뜑 넂븯떎. 怨듬났 떆 삁떦쓽 寃쎌슦룄 궓꽦씠 98.8 mg/dL, 뿬꽦씠 93.1 mg/dL濡 궓꽦씠 뜑 넂븯떎. 궓꽦 긽옄쓽 씉뿰瑜좎 怨쇨굅 씉뿰옄뒗 28.4%, 쁽옱 씉뿰옄뒗 26.9%씠뿀떎. 삉븳 쟾泥 긽옄뿉꽌 떦눊蹂 쑀蹂 솚옄뒗 8.9%씠뿀怨, 떦눊蹂 媛議깅젰씠 엳뒗 긽옄뒗 14.5%씠뿀떎(Table 1).

General characteristics of the study population

All subjects (N=4,274) Subjects with CVD (N=1,790) Healthy subjects (N=2,484)
Mean ± SD Mean ± SD Mean ± SD
Age, year 52.2±10.2 54.9±10.7 50.2±9.4
Weight, kg 67.4±11.1 68.4±10.7 66.7±11.3
Waist circumference, cm 84.1±9.0 86.0±8.6 82.1±9.0
Body mass index, kg/m2 24.4±3.0 24.9±2.9 24.1±2.9
Fasting blood sugar, mg/Dl 97.0±22.6 100.4±25.6 94.6±19.7
Systolic blood pressure, mmHg 121.9±14.5 125.4±15.3 119.4±13.3
Diastolic blood pressure, mmHg 78.2±10.8 77.6±10.9 78.7±10.7
HDL-C, mg/dL 50.9±11.6 49.5±10.4 52.0±12.3
LDL-C, mg/dL 116.8±31.8 112.4±34.1 119.2±30.1
Triglycerides, mg/dL 143.7±96.7 156.4±112.6 134.8±82.5
% % %
Smoking status Ex 28.4 33.3 25.2
Current 26.9 24.9 28.2
Cardiovascular disease 41.9 41.9 41.9
Diabetes* 8.9 12.4 6.5
Family history of diabetes 14.5 11.3 16.8

Abbreviations: SD, standard deviation; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; CVD, cardiovascular disease

*Diabetes was defined as fasting serum glucose ≥ 126 mg/dL or medication



떦눊蹂 媛議깅젰쓽 쑀臾댁뿉 뵲瑜 떦눊蹂묎낵쓽 濡쒖뒪떛 쉶洹遺꾩꽍 뿰졊, 꽦蹂, 닔異뺢린삁븬, HDL 肄쒕젅뒪뀒濡, 泥댁쭏웾吏닔 벑쓣 넻젣븯硫댁꽌 씠猷⑥뼱議뚮떎(Table 2). 쟾泥 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.80諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 2.80; 95% CI, 2.14~3.65). 삉븳, 궓꽦 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.76諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀怨(OR, 2.76; 95% CI, 2.04~3.73), 뿬꽦 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 3.13諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 3.13; 95% CI, 1.77~5.54). 利, 궓꽦怨 뿬꽦뿉꽌 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦뿉꽌 겙 李⑥씠뒗 뾾뿀떎. 떖삁愿吏덊솚씠 뾾뒗 嫄닿컯븳 긽옄뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.29諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 2.29; 95% CI, 1.57~3.35).

Odds ratios (OR) of the family history of diabetes for diabetes in the population (n = 4,274)

Normal Diabetes*
Model 1 Model 2
Subjects FHD N (%) N (%) OR (95% CI) P-value OR (95% CI) P-value
All (n = 4,274) No 3,367 (86.5) 287 (75.1) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 525 (13.5) 95 (24.9) 2.65 (2.04~3.43) 2.80 (2.14~3.65)
Men No 2,273 (87.1) 222 (75.0) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 336 (12.9) 74 (25.0) 2.67 (1.98~3.59) 2.76 (2.04~3.73)
Women No 1,094 (85.4) 65 (75.6) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 189 (14.7) 21 (24.4) 2.64 (1.53~4.56) 3.13 (1.77~5.54)
All Healthy (n = 2,484) No 1,949 (83.9) 118 (73.3) 1.00 (reference) <0.001 1.00 (reference) <0.001
Yes 374 (16.1) 43 (26.7) 2.29 (1.57~3.34) 2.29 (1.57~3.35)

Model 1: Adjusted for age and sex, Model 2: Adjusted for age, sex, systolic blood pressure, HDL cholesterol, and body mass index

*Diabetes was defined as fasting serum glucose ≥126 mg/dL or medication

Abbreviations: OR, odds ratio; CI, confidence interval; FHD, family history of diabetes



쟾泥 긽옄뿉 빐꽌 泥댁쭏웾吏닔 뿰졊쓽 以묒븰媛믪쓣 湲곗쑝濡 긽옄瑜 굹늻뼱꽌 떦눊蹂 媛議깅젰쓽 쑀臾댁뿉 뵲瑜 떦눊蹂묎낵쓽 愿젴꽦 遺꾩꽍씠 뿰졊, 꽦蹂, 닔異뺢린삁븬, HDL 肄쒕젅뒪뀒濡, 泥댁쭏웾吏닔 벑쓣 넻젣븯硫댁꽌 씠猷⑥뼱議뚮떎(Table 3). 泥댁쭏웾吏닔媛 以묒븰媛 씠븯쓽 留덈Ⅸ 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.98諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀怨(OR, 2.98; 95% CI, 1.96~4.52), 泥댁쭏웾吏닔媛 以묒븰媛 씠긽씤 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.73諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 2.73; 95% CI, 1.93~3.86). 利, 泥댁쭏웾吏닔쓽 以묒븰媛믪쑝濡 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦뿉꽌 겙 李⑥씠뒗 뾾뿀떎. 삉븳, 굹씠媛 以묒븰媛 씠븯쓽 젇 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 3.36諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀怨(OR, 3.36; 95% CI, 2.20~5.13), 굹씠媛 以묒븰媛 씠긽씤 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.48諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 2.48; 95% CI, 1.76~3.50). 利, 굹씠쓽 以묒븰媛믪쑝濡 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦 젇 援곗뿉꽌 怨좊졊援곕낫떎 洹 愿젴꽦씠 빟媛 뜑 넂븯떎.

Odds ratios (OR) of the family history of diabetes for diabetes in strata of median BMI and median age in Korean population (n = 4,274)

Normal Diabetes*
Subjects FHD N (%) N (%) ORa (95% CI) P-value
BMI<24.33 No 1,724 (86.6) 112 (74.7) 1.00 (reference)
Yes 267 (13.4) 38 (25.3) 2.98 (1.96~4.52) <0.001
BMI>=24.33 No 1,643 (86.4) 175 (75.4) 1.00 (reference)
Yes 258 (13.6) 57 (24.6) 2.73 (1.93~3.86) <0.001
Age<52 No 1,652 (83.7) 70 (63.6) 1.00 (reference)
Yes 323 (16.3) 40 (36.4) 3.36 (2.20~5.13) <0.001
Age>=52 No 1,715 (89.5) 217 (79.8) 1.00 (reference)
Yes 202 (10.5) 55 (20.2) 2.48 (1.76~3.50) <0.001

aAdjusted for age, sex, systolic blood pressure, HDL cholesterol, and body mass index

*Diabetes was defined as fasting serum glucose ≥126 mg/dL or medication

P for interaction between obesity (BMI>=24.33) and FHD = 0.7914, P for interaction between older age (Age>=52) and FHD = 0.3712

Abbreviations: OR, odds ratio; CI, confidence interval; FHD, family history of diabetes; BMI, body mass index


怨 李

蹂 뿰援щ뒗 븳 븰蹂묒썝뿉꽌 嫄닿컯寃吏꾩쓣 諛쏆 4,274紐낆쓽 븳援씤 궓꽦, 뿬꽦쓣 긽쑝濡 뿰졊蹂, BMI 蹂꾨줈 떦눊蹂 媛議깅젰뿉 뵲瑜 떦눊蹂묒쓽 愿젴꽦쓣 遺꾩꽍븳 寃곌낵씠떎. 湲곗〈쓽 援궡 꽑뻾 뿰援щ뱾뿉꽌룄 떦눊蹂묎낵 떦눊蹂 媛議깅젰쓽 愿젴꽦쓣 蹂닿퀬븯떎. Kim et al. (2017)씠 援誘쇨굔媛뺤쁺뼇議곗궗 긽옄뱾뿉 븯뿬 遺꾩꽍븳 寃곌낵뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 1.40諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 1.40; 95% CI, 1.13~1.73) (Kim et al., 2017). 理쒓렐쓽 떎瑜 븳援씤 긽옄 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 1.57諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 1.58; 95% CI, 1.37~1.82) (Ustulin et al., 2018). 蹂 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.80諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎. 利, 씠쟾 뿰援щ낫떎 떦눊蹂 媛議깅젰쓽 뜑 넂 愿젴꽦쓣 솗씤븯떎.

씠쟾 븳援씤 긽 뿰援щ낫떎 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 뜑 넂 愿젴꽦쓣 蹂댁씤 씠쑀濡쒕뒗 씠쟾 뿰援щ뱾씠 遺遺 嫄닿컯븳 궗엺留뚯쓣 긽쑝濡 븯쑝굹 蹂 뿰援 긽옄 4,274紐 以묒뿉꽌 1,790紐낆 떖삁愿吏덊솚 솚옄(41.9%)씤 寃껋씠 븯굹쓽 썝씤씪 닔 엳寃좊떎. 蹂 뿰援ъ뿉꽌 떖삁愿吏덊솚씠 뾾뒗 嫄닿컯븳 긽옄留뚯쓣 遺꾩꽍뻽쓣 븣 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 2.29諛 넂 떦눊蹂묒쓽 쐞뿕쓣 솗씤븯떎.

븳렪 理쒓렐 以묎뎅씤怨 씪蹂몄씤쓣 긽쑝濡 븳 뿰援ъ뿉꽌룄 蹂 뿰援ъ 鍮꾩듂븯寃 넂 愿젴꽦쓣 蹂닿퀬븯떎. 理쒓렐 以묎뎅씤쓣 긽쑝濡 븳 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 3.57諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 3.57; 95% CI, 2.95~4.33) (Ye et al., 2021). 洹몃━怨 2013뀈쓽 씪蹂몄씤 긽 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 1.84諛 넂 떦눊蹂묒쓽 쐞뿕쓣 蹂닿퀬븯怨, 듅엳 뼱癒몃땲媛 솚옄씤 긽옄뿉꽌뒗 2.56諛곗쓽 愿젴꽦쓣 蹂닿퀬븯떎(OR, 2.56; 95% CI, 1.67~3.92) (Sakurai et al., 2013).

理쒓렐 씪蹂몄씤쓣 긽쑝濡 븳 洹쒕え 肄뷀샇듃 뿰援ъ뿉꽌뒗 泥댁쭏웾吏닔쓽 蹂솕媛 젣2삎 떦눊蹂 諛쒖깮怨 넂 愿젴씠 엳쓬쓣 蹂닿퀬뻽떎(Okada et al., 2021). 以묐뀈쓽 뒪썾뜶 궓꽦, 뿬꽦쓣 긽쑝濡 븳 뿰援ъ뿉꽌뒗 泥댁쭏웾吏닔媛 30 씠븯쓽 留덈Ⅸ 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 3.9諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀怨, 泥댁쭏웾吏닔媛 30 씠긽씤 鍮꾨쭔븳 긽옄뿉꽌 떦눊蹂 媛議깅젰씠 엳뒗 긽옄媛 떦눊蹂 媛議깅젰씠 뾾뒗 긽옄 鍮꾧탳븯뿬꽌 11.1諛 넂 떦눊蹂묒쓽 쐞뿕씠 솗씤릺뿀떎(OR, 11.1; 95% CI, 4.8~25.7). 利, 泥댁쭏웾吏닔 30쓣 湲곗쑝濡 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦뿉꽌 겙 李⑥씠媛 엳뿀떎(Hilding et al., 2006). 洹몃━怨 2013뀈쓽 以묎뎅씤怨 뱶씤뱾쓣 긽쑝濡 븳 뿰援ъ뿉꽌룄 泥댁쭏웾吏닔 30 씠긽씤 鍮꾨쭔븳 援곗뿉꽌 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦씠 뜑 겙 寃껋쓣 솗씤븯떎(Ning et al., 2013). 洹몃윭굹 2013뀈쓽 씪蹂몄씤 긽 뿰援ъ뿉꽌뒗 蹂 뿰援 寃곌낵 鍮꾩듂븯寃 泥댁쭏웾吏닔 25瑜 湲곗쑝濡 긽옄瑜 援щ텇븯뿬꽌 떦눊蹂 媛議깅젰怨 떦눊怨쇱쓽 愿젴꽦쓣 蹂댁븯쓣 븣 겙 李⑥씠媛 뾾떎怨 蹂닿퀬븯떎(Sakurai et al., 2013). 蹂 뿰援ъ뿉꽌뒗 泥댁쭏웾吏닔쓽 以묒븰媛믪쑝濡 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦뿉꽌 겙 李⑥씠뒗 뾾뿀떎.

蹂 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 넂 愿젴꽦쓣 솗씤븯떎. 삉븳 뿰졊뿉 뵲씪꽌 긽옄瑜 援щ텇븯뿬 遺꾩꽍븯쓣 븣 뿰졊쓽 以묒븰媛믪씤 52꽭 誘몃쭔쓽 젇 긽옄뿉꽌 洹 愿젴꽦씠 뜑 넂븯떎. 理쒓렐뿉 45꽭 씠긽쓽 샇二쇱씤뱾쓣 긽쑝濡 븳 肄뷀샇듃 뿰援ъ뿉꽌룄 떦눊蹂 媛議깅젰씠 엳쑝硫 떦눊蹂 諛쒖깮 쐞뿕씠 1.65諛 넂쓬쓣 蹂닿퀬뻽떎(Zhang et al., 2020). 理쒓렐 20~44꽭쓽 젇 꽦씤쓣 긽쑝濡 븳 떎瑜 뿰援ъ뿉꽌뒗 뵾留 씤뵒뼵(Pima Indians)蹂대떎 궓븘떆븘씤(South Asians)뱾뿉꽌 떦눊蹂 媛議깅젰怨 떦눊蹂 諛쒖깮 쐞뿕쓽 愿젴꽦씠 넂쓬쓣 蹂닿퀬뻽떎(Narayan et al., 2021). 샇二 泥냼뀈뱾쓣 긽쑝濡 븳 理쒓렐 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 泥냼뀈뱾씠 鍮꾨쭔, 닔硫 뒿愿 벑뿉꽌 媛議깅젰씠 뾾뒗 泥냼뀈蹂대떎 굹걶 뒿愿쓣 媛吏怨 엳쓬쓣 蹂닿퀬뻽떎(Downing et al., 2020). 븳렪 理쒓렐 슦由щ굹씪 꽦씤쓣 긽쑝濡 븳 뿰援ъ뿉꽌뒗 떦눊蹂 媛議깅젰씠 엳뒗 궗엺뿉꽌 긽쟻쑝濡 넂 寃쎈룞留 궡留 몢猿섎 蹂닿퀬뻽떎(Shim et al., 2021).

떦눊蹂 媛議깅젰怨 떦눊蹂묎낵쓽 愿젴꽦쓣 蹂 뿰援ъ꽌 遺꾩꽍뻽쓣 븣 궓꽦蹂대떎 뿬꽦뿉꽌 議곌툑 뜑 넂 愿젴꽦쓣 솗씤뻽떎. 뿰援 긽옄쓽 룊洹 뿰졊 궓꽦씠 51.9꽭, 뿬꽦씠 52.8꽭濡 뿬꽦씠 넂븯떎. 삉븳 泥댁쭏웾吏닔, 怨듬났 떆 삁떦, 삁븬룄 궓꽦씠 뿬꽦蹂대떎 넂븯떎. 듅엳 궓꽦 긽옄쓽 쁽옱 씉뿰瑜좎 37.3%, 뿬꽦쓽 쁽옱 씉뿰瑜좎 3.9%濡 李⑥씠媛 而몃떎.

蹂 뿰援щ뒗 떒硫 뿰援ъ쓽 븳怨꾩젏쓣 媛吏怨 엳떎. 삉븳 떦눊蹂묒쓣 怨듬났 떆 삁떦怨 떦눊蹂 빟臾 蹂듭슜젰쑝濡 젙쓽뻽怨, HbA1C 닔移섎뒗 떦눊蹂 젙쓽뿉 룷븿븯吏 紐삵븯떎. 蹂 뿰援ъ쓽 寃곌낵뒗 怨좊졊옄蹂대떎뒗 52꽭 誘몃쭔쓽 젇 援곗뿉꽌 떦눊蹂 媛議깅젰씠 떦눊蹂 諛쒖깮 쐞뿕怨 愿젴꽦씠 넂쓬쓣 蹂닿퀬븳 寃껋뿉 쓽쓽媛 엳떎. 씠뒗 젇 援곗쓣 긽쑝濡 뿰援ы븳 쇅援쓽 寃곌낵뱾怨 씪移섑븳떎(Zhang et al., 2020; Narayan et al., 2021). 씠뿉 븯뿬뒗 異뷀썑 옣湲곗쟻씤 쟾뼢쟻씤 肄뷀샇듃 뿰援ш 븘슂븯寃좊떎.

ACKNOWLEDGEMENT

This paper was funded by the Basic Science Research Program of the National Research Foundation of Korea through the Ministry of Education, Science, and Technology (2018R1D1A1B07050834) and funded by the Korea medical institute (KMI) in 2021.

CONFLICT OF INTEREST

The authors declare that they have no conflict of interest.

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