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A Study on the Trend of Changes in the Positive Rate of Hepatitis B Surface Antigens and Antibodies over the Last 9 Years in One Health Care Center
Biomed Sci Letters 2023;29:314-320
Published online December 31, 2023;  https://doi.org/10.15616/BSL.2023.29.4.314
© 2023 The Korean Society For Biomedical Laboratory Sciences.

Kang-Sil Lee1,*, Sang-Ha Kim2,*, Young-Bin Yu3,†,** and Young-Kwon Kim4,†,**

1Department of Laboratory Medicine, Cheongyang-gun Health Medical Center, Chungnam 33324, Korea
2Department of Laboratory Medicine, Konyang University Hospital, Daejeon 35365, Korea
3Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, Daejeon 35365, Korea
4Department of Health Sciences, The Graduate School of Konyang University, Daejeon 35365, Korea
Correspondence to: Young-Kwon Kim. Department of Health Sciences, The Graduate School of Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea.
Tel: +82-10-6436-3245, Fax: +82-42-543-6370, e-mail: ykkim3245@konyang.ac.kr
Young-Bin Yu. Department of Biomedical Laboratory Science, College of Medical Sciences, Konyang University, 158 Gwanjeodong-ro, Seo-gu, Daejeon 35365, Korea.
Tel: +82-10-4644-3126, Fax: +82-42-600-8435, e-mail: ybyoo@konyang.ac.kr
*Researcher, **Professor.
Received November 1, 2023; Revised December 1, 2023; Accepted December 5, 2023.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
 Abstract
The purpose of this study was to provide basic data on hepatitis B infection control in the community through the results of the hepatitis B surface antigen and antibody tests conducted at the Cheongyang-County Health Medical Center. From 2012 to 2020, we retrospectively analyzed the HBsAg, HBsAb, HBeAg, HBeAb, and HBV DNA results of 7,329 hepatitis B-related testers. Among 7,329 subjects, the HBsAg positivity rate was 1.7%, and the positivity rate according to age was the highest at 4.4% in their 30s, 4.2% in their 40s, 4.1% in their 50s, 2.0% in their 60s, 1.9% in their 70s and over, and 10 it was shown in the order of 0.3% from less than large. The HBsAb positivity rate was 43.1% for men, 38.2% for men, and 46.7% for women (P<0.001). To summarize the above results, for infection control of hepatitis B in Cheongyang-County, hepatitis surface antigen proton management is required for those in their 30s or older, and it is thought that efforts to acquire immunity are necessary for those in their 20s or younger.
Keywords : Hepatitis B, HBsAg, HBsAb, Positive rate, Infection control, Health Medical Center
꽌 濡

2020뀈 넻怨꾩껌 궗留앹썝씤 諛쒗몴뿉 뵲瑜대㈃ 吏궃 10뀈 룞븞 궗留앹썝씤쓽 7쐞뿉꽌 8쐞瑜 李⑥븷 젙룄濡 슦由щ굹씪뒗 媛꾩쭏솚쑝濡 씤븳 궗留앸쪧씠 넂쓣 肉먮쭔 븘땲씪 궗留앹썝씤 1쐞瑜 李⑥븯뒗 븙꽦 떊 깮臾 以묒뿉꽌룄 룓븫뿉 씠뼱 媛꾩븫씠 쐞븫怨 옣븫蹂대떎 넂 닚쐞瑜 李⑥븯怨 엳떎.

媛꾩븫 媛꾩씠 썝諛쒖씤 寃쎌슦 媛꾩꽭룷븫, 媛꾨궡떞愿븫, 媛꾨え꽭룷醫, 媛꾩쓽 삁愿쑁醫 벑씠 엳쑝硫 媛꾩꽭룷븫씠 留롪퀬, 以묒슂븳 썝씤 B삎 諛 C삎 媛꾩뿼 諛붿씠윭뒪쓽 媛먯뿼씠떎(Statistics Korea, 2021). 援궡 留뚯꽦 媛꾩뿼怨 媛꾧꼍蹂利 솚옄쓽 빟 70%, 媛꾩븫 솚옄쓽 빟 60%뒗 B삎 媛꾩뿼 諛붿씠윭뒪 媛먯뿼씠 썝씤쑝濡 삁븸, 泥댁븸, 媛먯뿼맂 궗엺怨쇱쓽 꽦쟻 젒珥, 二쇱궗湲 諛붾뒛 怨듬룞 궗슜 벑쓣 넻빐 媛먯뿼맂떎(Kim et al., 2008).

듅엳 諛붿씠윭뒪 蹂댁쑀 뿬꽦쓽 異쒖궛 떆 븘湲곌 媛먯뿼릺뒗 紐⑥옄媛 닔吏곴컧뿼씠 媛옣 以묒슂븳 媛먯뿼寃쎈줈濡 쟾泥 留뚯꽦 媛먯뿼옄쓽 40~50%瑜 二쇱궛湲곌컧뿼씠 李⑥븳떎(Stevens et al., 1975). B삎 媛꾩뿼 諛붿씠윭뒪 媛먯뿼뿉꽌 꽦씤湲곗뿉뒗 빟 5%뿉꽌留 留뚯꽦쑝濡 吏꾪뻾븯뒗뜲 諛섑빐, 二쇱궛湲곗뿉뒗 遺遺 遺덊쁽꽦 媛먯뿼 썑 90%媛 留뚯꽦 媛꾩뿼씠 맂떎. 씪遺 湲됱꽦 B삎 媛꾩뿼 솚옄뿉꽌뒗 떖媛곹븳 媛꾩뿼쓣 씪쑝耳 湲됱꽦 媛꾨쟾쑝濡 吏꾪뻾븳떎(WHO, 2021).

湲됱꽦 B삎 媛꾩뿼쓽 뿰媛 諛쒖깮 嫄댁닔뒗 2009뀈뿉 1,746紐낆쓣 젙젏쑝濡 젏李 媛먯냼 븯떎媛 2013뀈뿉 117紐낆쑝濡 理쒖瑜 湲곕줉븯쑝굹, 씠썑 떎떆 利앷븯湲 떆옉븯뿬 2019뀈 389紐, 2020뀈 382紐낆씠 諛쒖깮븯떎(KDCA, Infectious Diseases Surveillance Yearbook, 2020).

슦由щ굹씪쓽 B삎 媛꾩뿼 몴硫댄빆썝(hepatitis B surface antigen, HBsAg) 뼇꽦瑜좎 B삎 媛꾩뿼 諛깆떊씠 궗슜릺湲 씠쟾씤 1970뀈 諛 1980 珥덉뿉뒗 쟾 씤援ъ쓽 7~8%, 媛엫湲 궛紐 뿰졊痢듭 5%, 븰룞湲 뿰졊痢듭 4.8%씠뿀떎(Choung et al., 2002; Seo et al., 2005).

洹몃윭굹 1983뀈뿉 B삎 媛꾩뿼 삁諛 젒醫낆씠 슦由щ굹씪뿉 泥섏쓬 룄엯릺怨, 1995뀈 쁺쑀븘 긽 젙湲 삁諛 젒醫낆쓽 떆뻾쑝濡 95% 씠긽쓽 뼱由곗씠 셿쟾 젒醫낅쪧 쑀吏 2002뀈 7썡遺꽣 떎떆맂 B삎 媛꾩뿼 二쇱궛湲곌컧뿼 삁諛⑹궗뾽 떆뻾쑝濡 B삎 媛꾩뿼 몴硫댄빆썝 뼇꽦瑜좎 留 10꽭 씠긽 쟾泥 씤援ъ쓽 빟 3%(궓옄 3.4%, 뿬옄 2.6%), 븰룞湲 뿰졊痢듭쓽 0.2%留뚯씠 HBV뿉 媛먯뿼릺뼱 엳쓣 젙룄濡 쁽엳 媛먯냼븯쑝굹(Choung et al., 2002), 뿬쟾엳 留ㅻ뀈 15,000뿬紐낆쓽 떊깮븘媛 二쇱궛湲곌컧뿼쓽 쐞뿕뿉 끂異쒕릺怨 엳怨(Jeong, 2013), 二쇱궛湲곌컧뿼 쇅뿉 꽦 젒珥, 닔삁 洹몃━怨 삤뿼맂 湲곌뎄뿉 쓽븳 媛먯뿼옄쓽 삁븸씠굹 泥댁븸뿉 끂異쒖뿉 쓽븳 닔룊쟻 媛먯뿼쓽 쐞뿕뿉 삁諛 젒醫낆쓣 떎떆븯吏 븡 뿰졊 빆泥 誘명삎꽦 옄媛 끂異쒕릺뼱 엳떎. 2020뀈 湲됱꽦 B삎 媛꾩뿼 떊怨 嫄댁닔 382紐 以 20 씠긽뿉꽌 378紐(99.0%)쓣 李⑥뻽떎(KDCA, Infectious Diseases Surveillance Yearbook, 2020).

쟾援쟻쑝濡 2016뀈遺꽣쓽 湲됱꽦 B삎 媛꾩뿼 솚옄 닔쓽 利앷 븿猿 B삎 媛꾩뿼쓽 쑀蹂묐쪧씠 넂 遺곹븳 씠깉二쇰쇱씠굹 쇅援씤 洹쇰줈옄뱾쓽 냽珥뚯쑝濡쒖쓽 씠룞쑝濡 씤븳 吏뿭 궡 媛먯뿼쓽 쐞뿕쓣 媛꾧낵빐꽌뒗 븞 맆 寃껋씠떎.

씠踰 뿰援ъ뿉꽌뒗 2012뀈遺꽣 2020뀈源뚯 9뀈媛 떒씪 湲곌뿉꽌 씠猷⑥뼱吏 寃궗 옄猷뚮 遺꾩꽍븯뿬 泥뼇援 吏뿭 HBsAg 뼇꽦瑜좎쓽 꽦蹂, 뿰졊蹂 듅吏뺢낵 뿰룄 寃쎄낵뿉 뵲瑜 뼇꽦瑜 蹂솕뿉 빐 議곗궗븯떎.

뜑遺덉뼱 B삎 媛꾩뿼 몴硫댄빆泥(HBsAb)뿉 븳 寃곌낵 遺꾩꽍쓣 넻븯뿬 吏뿭 궡 빆泥 삎꽦瑜좉낵 븿猿 HBsAg 뼇꽦옄쓽 異붽 寃궗瑜 넻빐 B삎 媛꾩뿼 蹂닿퇏옄뱾쓽 뼇긽쓣 븣븘蹂닿퀬, 泥뼇援 吏뿭 궡 B삎 媛꾩뿼 솚옄 愿由щ 쐞븳 李멸퀬 옄猷뚮 젣怨듯븯怨좎옄 븳떎.

뿰援щ긽 諛 諛⑸쾿

뿰援 긽

2012뀈 1썡遺꽣 2020뀈 12썡源뚯 9뀈媛 泥뼇援 蹂닿굔쓽猷뚯썝뿉꽌 쇅옒 吏꾨즺, 嫄닿컯 寃吏, 誘쇱썝 꽌瑜 諛쒓툒쓣 쐞빐 떆뻾맂 B삎 媛꾩뿼 寃궗옄 7,329紐낆쓣 긽쑝濡 뿰룄蹂, 꽦蹂, 뿰졊蹂 遺꾩꽍쓣 븯떎.

뿰援 諛⑸쾿

紐⑤뱺 삁泥븰쟻 HBV 愿젴 몴吏옄뱾뿉 빐꽌뒗 썑뼢쟻 遺꾩꽍쓣 븯쑝硫, 뿰룄蹂, 뿰졊蹂, 꽦蹂꾩뿉 뵲瑜 蹂솕쓽 李⑥씠瑜 議곗궗븯떎. HBsAg怨 HBsAb 寃궗뒗 썝궡뿉꽌 젙꽦 寃궗씤 SD BIOLINE HBsAg怨 Anti-HBs (Standard Diagnostics Inc., Korea)瑜 궗슜븯뿬 硫댁뿭겕濡쒕쭏넗洹몃옒뵾踰뺤쑝濡 寃궗븯怨, 떎瑜 HBV 愿젴 異붽 寃궗 빆紐⑸뱾 궪愿묒쓽猷뚯옱떒뿉 쓽猶고븯뿬 HBeAg怨 HBeAb뒗 Architect i2000 SR (Abbott, USA)쓣 궗슜븯뿬 솕븰諛쒓킅硫댁뿭踰(Chemiluminescence microparticle immunoassay, CMIA)쑝濡 痢≪젙븯怨, HBV DNA 젙웾 寃궗뒗 Cobas Ampliperp & TaqMan (Roche, Germany)쓣 궗슜븯뿬 Real time PCR踰뺤쑝濡 痢≪젙븯떎.

넻怨꾨텇꽍

씠踰 뿰援 넻怨꾨텇꽍 R Studio for Windows瑜 궗슜븯떎. 뿰냽蹂닔뒗 鍮덈룄 諛 諛깅텇쑉(%)쓽 삎깭濡 굹궡뿀怨, 뼇꽦瑜좎쓽 鍮꾧탳뒗 2 寃젙, 2 異붿꽭寃젙(2 for trend test), 濡쒖뒪떛 쉶洹遺꾩꽍쓣 씠슜븯떎. P-value뒗 0.05 誘몃쭔씤 寃쎌슦瑜 넻怨꾩쟻쑝濡 쑀쓽븳 寃껋쑝濡 빐꽍븯떎.

寃 怨

뿰援 긽옄쓽 씪諛섏쟻 듅꽦

뿰援 긽옄뒗 쟾泥 7,329紐낆쑝濡 궓옄뒗 3,238 (44.2%)紐, 뿬옄뒗 4,091 (55.8%)紐낆쓽 遺꾪룷瑜 蹂댁떎.

뿰졊蹂 遺꾩꽍뿉꽌뒗 19꽭 씠븯 2,667紐(36.4%), 70 씠긽씠 1,566紐(21.4%)쑝濡 몢 뿰졊뿉꽌 57.8%瑜 李⑥븯怨, 20媛 971紐(13.2%)씠뿀떎. 19꽭 씠븯 뿰졊쓽 寃궗옄媛 留롮 씠쑀뒗 以묓븰援 1븰뀈 븰깮 寃吏꾧낵 湲곗닕궗 젣異쒖슜 嫄닿컯吏꾨떒꽌 諛쒓툒 떆 B삎 媛꾩뿼 寃궗媛 룷븿릺뼱 엳湲 븣臾몄씠떎.

뿰룄蹂 遺꾩꽍뿉꽌뒗 2012뀈 1,240紐(16.9%)쑝濡 媛옣 留롮븯쑝硫, 2013뀈 880紐(12%), 2014뀈 863紐(11.8%), 2015뀈 594紐(8.1%), 2016뀈 664紐(9.1%), 2017뀈 583紐(8%), 2018뀈 577紐(7.9%), 2019뀈 951紐(13%), 2020뀈 977紐(13.3%)씠뿀떎. 2012뀈뿉 긽옄媛 留롮 寃껋 씠 썑뿉 떎떆맂 諛섎났 寃궗옄瑜 젣쇅뻽湲 븣臾몄씠떎(Table 1).

Age and gender distribution in this study
N (%)

Age group Male Female Total
Less than 19 1,362 (42.0%) 1,305 (31.9%) 2,667 (36.4%)
20~29 500 (15.4%) 471 (11.5%) 971 (13.2%)
30~39 117 (3.6%) 276 ( 6.7%) 393 ( 5.4%)
40~49 312 (9.6%) 393 (9.6%) 705 (9.6%)
50~59 176 (5.4%) 345 ( 8.4%) 521 (7.1%)
60~69 186 (5.7%) 320 ( 7.8%) 506 (6.9%)
Above 70 585 (18.1%) 981 (24.0%) 1,566 (21.4%)
Total 3,238 (44.2%) 4,091 (55.8%) 7,329 (100%)


B삎 媛꾩뿼 諛붿씠윭뒪 몴吏옄 뼇꽦瑜

쟾泥 긽옄쓽 HBsAg, HBsAb 뼇꽦瑜좎 媛곴컖 124紐(1.7%), 2,699紐(43.1%)씠뿀떎(Table 2, 4).

Overall seropositivities of HBsAg
N (%)

Variables Positive (%) Negative (%) Chi-square test
Total 124 (1.7) 7,132 (98.3) 2 P-value P for trend test
Year 9.994 0.265 0.603
2012 23 (1.9) 1,205 (98.1)
2013 10 (1.2) 859 (98.8)
2014 18 (2.1) 824 (97.9)
2015 5 (0.9) 582 (99.1)
2016 13 (2.0) 651 (98.0)
2017 12 (2.1) 568 (97.9)
2018 8 (1.4) 567 (98.6)
2019 12 (1.3) 932 (98.7)
2020 23 (2.4) 944 (97.6)
Gender 0.715 0.398 0.398
Male 50 (1.6) 3,147 (98.4)
Female 74 (1.8) 3,985 (98.2)
Age group 93.904 <0.001 <0.001
Less than 19 8 (0.3) 2,655 (99.7)
20~29 10 (1.0) 947 (99.0)
30~39 17 (4.4) 369 (95.6)
40~49 29 (4.2) 665 (95.8)
50~59 21 (4.1) 490 (95.9)
60~69 10 (2.0) 490 (98.0)
Above 70 29 (1.9) 1,516 (98.1)


Overall seropositivities of HBsAb
N (%)

Variables Positive (%) Negative (%) Chi-square test
Total 2,700 (43.1) 3,563 (56.9) 2 P-value P for trend test
Year 23.570 0.003 0.886
2012 444 (44.4) 557 (55.6)
2013 299 (41.9) 415 (58.1)
2014 333 (45.6) 398 (54.4)
2015 218 (41.9) 302 (58.1)
2016 220 (40.2) 327 (59.8)
2017 212 (43.4) 276 (56.6)
2018 163 (34.5) 309 (65.5)
2019 365 (44.2) 461 (55.8)
2020 446 (46.3) 518 (53.7)
Gender 45.075 <0.001 <0.001
Male 1,023 (38.2) 1,652 (61.8)
Female 1,677 (46.7) 1,911 (53.3)
Age group 397.860 <0.001 <0.001
Less than 19 431 (25.3) 1,275 (74.7)
20~29 360 (37.9) 589 (62.1)
30~39 224 (59.3) 154 (40.7)
40~49 358 (52.2) 328 (47.8)
50~59 289 (57.8) 211 (42.2)
60~69 281 (56.1) 220 (43.9)
Above 70 757 (49.1) 786 (50.9)


HBsAg 뼇꽦瑜좎 궓옄 50紐(1.6%), 뿬옄 74紐(1.8%)쑝濡 뿬옄媛 궓옄蹂대떎 뜑 넂寃 굹궗쑝굹 넻怨꾩쟻쑝濡 쑀쓽븳 愿젴꽦 뾾뿀떎.

뿰룄蹂 HBsAg 뼇꽦瑜좎 2012뀈 1.9%, 2013뀈 1.2%, 2014뀈 2.1%, 2015뀈 0.9%, 2016뀈 2.0%, 2017뀈 2.1%, 2018뀈 1.4%, 2019뀈 1.3%, 2020뀈 2.4%濡 슌졆븳 李⑥씠뒗 蹂댁씠吏 븡븯떎(Table 2).

뿰졊蹂 HBsAg 뼇꽦瑜좎 10 씠븯 0.3%, 20 1.0%, 30 4.4%, 40 4.2%, 50 4.1%, 60 2.0%, 70 씠긽 1.9%濡 30뿉꽌 媛옣 넂 뼇꽦瑜좎쓣 굹궡뿀떎(Table 2, Fig. 1).

Fig. 1. Seropositivities of HBsAg according to age groups.

씪諛섏쟻 듅꽦뿉 쓽븳 HBsAg쓽 뼇꽦怨 쓬꽦쓽 李⑥씠瑜 寃利앺븯湲 쐞빐 濡쒖뒪떛 쉶洹遺꾩꽍쓣 떎떆븳 寃곌낵 2012뀈뿉 鍮꾪빐 2019뀈 0.086諛, 2020뀈 0.014諛 궙寃 굹궗떎(Table 3).

Logistic regression analysis of HBsAg

Variables B S.E. Exp (B) 95% CI P-value
Year
2012 1.000
2013 0.122 1.374 1.130 0.077~16.684 0.929
2014 0.221 1.349 1.248 0.089~17.537 0.870
2015 19.633 19561.192 3.361E8 0.000 0.999
2016 36.815 13863.676 9.738E15 0.000 0.998
2017 -0.258 1.170 0.773 0.078~7.659 0.826
2018 18.918 40192.970 1.644E8 0.000 1.000
2019 -2.459 1.071 0.086 0.010~0.698 0.022
2020 -4.242 1.191 0.014 0.001~0.148 <0.001
Gender
Male 1.000
Female -0.168 0.733 0.845 0.201~3.556 0.818
Age group
Less than 19 1.000
20~29 37.611 17906.719 2.1258E16 0.000 0.998
30~39 58.169 20414.484 1831E25 0.000 0.998
40~49 56.981 20414.484 5.577E24 0.000 0.998
50~59 58.498 20414.484 2.542E25 0.000 0.998
60~69 57.461 20414.484 9.019E24 0.000 0.998
Above 70 58.570 20414.484 2.732E25 0.000 0.998

B (Unstandardized Regression Coefficient, slope 棺), S.E (Standard Error), Exp (B) (Odds Ratio), CI (Confidence Interval)



HBsAb 뼇꽦瑜좎 궓옄 1,023紐(38.2%), 뿬옄 1,676紐(46.7%)濡 뿬옄뿉꽌 뜑 넂븯떎.

뿰룄蹂 HBsAb 뼇꽦瑜좎 2012뀈 44.4%, 2013뀈 41.9%, 2014뀈 45.6%, 2015뀈 41.9%, 2016뀈 40.2%, 2017뀈 43.4%, 2018뀈 34.5, 2019뀈 44.1%, 2020뀈 46.3%濡 2018뀈뿉 媛옣 궙寃 굹궗떎(Table 4, Fig. 2).

Fig. 2. Seropositivities of HBsAb according to years P-value: Male (<0.001), Female (<0.001), Total (<0.001).

뿰졊蹂 HBsAb 뼇꽦瑜좎 10 씠븯 25.3%, 20 37.9%, 30 59.3%, 40 51.4%, 50 57.8%, 60 56.1%, 70 씠긽 49.1%濡 10뿉꽌 媛옣 궙 뼇꽦瑜좎쓣 굹깉떎(Table 4, Fig. 3).

Fig. 3. Seropositivities of HBsAb according to age groups.

씪諛섏쟻 듅꽦뿉 뵲瑜 HBs Ab쓽 李⑥씠瑜 寃利앺븯湲 쐞빐 濡쒖뒪떛 쉶洹遺꾩꽍쓣 떎떆븳 寃곌낵, 씪諛섏쟻 듅꽦뿉 뵲瑜 HBs Ab 뼇꽦 쓬꽦뿉 鍮꾪빐 2012뀈蹂대떎 2019뀈뿉 11.083諛 넂寃 굹궗怨, 2020뀈蹂대떎뒗 83.058諛 넂寃 굹궗떎.

뿰졊蹂 洹몃9뿉꽌뒗 19꽭 씠븯蹂대떎 30~40 洹몃9씠 0.024諛 쟻寃 굹궗쑝硫, 40~50 洹몃9뿉꽌뒗 0.048諛, 50~60 洹몃9뿉꽌뒗 0.025諛, 60~70 洹몃9뿉꽌뒗 0.050諛, 70꽭 씠긽 0. 011諛 쟻寃 굹궗떎(Table 5).

Logistic regression analysis of HBsAb

Variables B S.E. Exp (B) 95% CI P-value
Year
2012 1.000
2013 0.479 1.103 1.614 0.186~14.027 0.664
2014 0.698 1.083 2.009 0.241~16.468 0.519
2015 -0.335 1.434 0.716 0.043~11.905 0.816
2016 -0.364 1.291 0.695 0.055~8.728 0.778
2017 0.294 1.122 1.342 0.149~12.098 0.793
2018 0.670 1.943 1.954 0.043~88.074 0.730
2019 2.405 1.029 11.083 1.476~83.251 0.019
2020 4.420 1.164 83.058 8.480~813.519 <0.001
Gender
Male 1.000
Female 0.386 0.597 1.471 0.457~4.738 0.517
Age group
Less than 19 1.000
20~29 -1.403 1.935 0.246 0.006~10.920 0.246
30~39 -3.716 1.448 0.024 0.001~0.416 0.010
40~49 -3.041 1.467 0.048 0.003~0.847 0.038
50~59 -3.701 1.473 0.025 0.001~0.443 0.012
60~69 -2.995 1.482 0.050 0.003~0.913 0.043
Above 70 -4.549 1.497 0.011 0.001~0.199 0.002

B (Unstandardized Regression Coefficient, slope 棺), S.E (Standard Error), Exp (B) (Odds Ratio), CI (Confidence Interval)



HBsAg 뼇꽦옄쓽 B삎 媛꾩뿼 愿젴 異붽 寃궗

뿰援 湲곌컙 룞븞 HBsAg 뼇꽦씠 솗씤맂 긽옄쓽 B삎 媛꾩뿼 愿젴 異붽 寃궗瑜 븿猿 議곗궗븯떎. 뿬윭 踰 寃궗瑜 떎떆븳 寃쎌슦뿉뒗 HBsAg瑜 븿猿 寃궗븳 궇쓽 寃곌낵濡 遺꾩꽍븯뿬 B삎 媛꾩뿼 몴硫댄빆썝씠 뼇꽦씤 떦떆쓽 寃곌낵瑜 뼸뿀떎. B삎 몴硫댄빆썝 뼇꽦옄 以 異붽 寃궗瑜 떎떆븳 긽옄쓽 鍮꾩쑉 40紐(32.3%)濡 빆紐⑸퀎濡 蹂대㈃ HBcAb 4.8%, HBeAg 32.3%, HBeAb 30.6%, HBV DNA 30.6%떎.

媛 빆紐⑹쓽 뼇꽦瑜좎 HBcAb 100%, HBeAg 55.0%, HBeAb 44.7%, HBV DNA 68.4%瑜 蹂댁떎(Table 6).

Additional laboratory tests in case of HBsAg positive
(N=124)

Additional test Test proportion N (%) Test positive proportion N (%)
HBcAb 6 (4.8) 6 (100)
HBeAg 40 (32.3) 22 (55.0)
HBeAb 38 (30.6) 17 (44.7)
HBV DNA 38 (30.6) 26 (68.4)

怨 李

B삎 媛꾩뿼 諛붿씠윭뒪 媛먯뿼쓣 쓽誘명븯뒗 삁以 HBsAg쓽 뼇꽦瑜좎 슦由щ굹씪뿉꽌 1983뀈 삁諛 諛깆떊 룄엯 씠썑 1992뀈뿉 쟾泥 씤援ъ쓽 8.6%媛 뼇꽦쓣 蹂댁怨, 2011뀈뿉뒗 3.1%濡 蹂닿퀬릺뿀떎. 듅엳 諛깆떊 룄엯怨 쁺쑀븘 긽 援媛삁諛 젒醫낆궗뾽쓽 꽦怨쇰줈 10뿉꽌 뼇꽦瑜좎씠 젏李 媛먯냼븯뿬 2019뀈뿉뒗 0.0%뿉 룄떖뻽떎(Jang et al., 1983; Chae et al., 2009; KDCA, 2020).

泥뼇援곗 異⑸궓쓽 씤援ш컧냼 吏뿭 以묒뿉꽌룄 씤援ш 媛옣 쟻 湲곗큹옄移섎떒泥댁씠硫, 泥뼇援 蹂닿굔쓽猷뚯썝 泥뼇援곗뿉꽌 쑀씪븯寃 寃궗떎쓣 슫쁺븯怨 엳뒗 쓽猷뚭린愿씠떎. 뿰援 긽옄 7,329紐낆 2016뀈 泥뼇援 씤援ъ쓽 24.4%뿉 빐떦븯뒗 닔씠誘濡 긽옄뱾쓽 HBsAg怨 HBsAb 뼇꽦瑜좎쓽 蹂솕 異붿꽭 遺꾩꽍씠 吏뿭 궗쉶 궡 B삎 媛꾩뿼 愿由щ 쐞븳 湲곗큹 옄猷뚭 맆 닔 엳떎뒗 媛꽕뿉 뿰援щ 떆뻾븯떎.

HBV 媛먯뿼쓽 쑀蹂묐쪧씠 넂 슦由щ굹씪쓽 留롮 HBsAg 뼇꽦瑜 뿰援ъ뿉꽌 吏뿭, 긽옄 諛 痢≪젙 諛⑸쾿뿉 뵲瑜 李⑥씠瑜 蹂댁씠怨 엳뒗뜲 씠 뿰援ъ뿉꽌뒗 쟾泥 뿰援 湲곌컙 룞븞뿉 19꽭 씠븯 뿰졊뿉꽌 0.3%濡 媛옣 궙 뼇꽦瑜좎쓣 蹂댁떎. 2012뀈 0.4%뿉꽌 젏李 媛먯냼븯떎媛 2019뀈뿉 0.8%, 洹몃━怨 2020뀈뿉 0.0%瑜 굹깉뒗뜲, 룞씪 湲곌컙뿉 쟾援 10~ 18꽭 뼇꽦瑜좎 2012뀈 0.7%뿉꽌 젏李 媛먯냼븯뿬 2019뀈뿉뒗 0.0%뿉 씠瑜대떎(KDCA, 2020).

援궡 쟾泥 씤援ъ쓽 B삎 媛꾩뿼 몴硫댄빆썝 뼇꽦瑜좎 1995뀈 8.3%뿉꽌 1998뀈 4.6%, 2005뀈 3.7%, 2012뀈 3.9%, 2019뀈 2.0%濡 쁽븯寃 媛먯냼븯뒗뜲(KDCA, 2020), 씠 뿰援ъ뿉꽌뒗 2012뀈 1.9%, 2019뀈 1.3%, 2020뀈 2.4%瑜 굹궡뿀떎. 2012뀈뿉 쟾援蹂대떎 궙 썝씤쑝濡 긽옄 以 븰깮 寃吏꾧낵 湲곗닕궗 젣異쒖슜 吏꾨떒꽌 紐⑹쟻쓽 19꽭 誘몃쭔 긽옄뱾쓽 鍮꾩쑉씠 넂 寃껋씠 썝씤쑝濡 蹂댁뿬 19꽭 誘몃쭔쓣 젣쇅븳 뼇꽦瑜좎 3.0%濡 쟾援 뼇꽦瑜좉낵 겙 李⑥씠瑜 蹂댁씠吏 븡븯쑝硫, 2020뀈뿉 씠쟾蹂대떎 넂 뼇꽦瑜좎쓣 蹂댁씠뒗 寃껋 2020뀈 궡怨 吏꾨즺떎쓽 寃궗 利앷媛 썝씤쑝濡 쑀異붾맂떎. 뿰졊 洹몃9蹂 議곗궗뿉꽌 2019뀈룄 쟾援쓽 蹂닿퀬뿉꽌뒗 10꽭 씠긽쓽 쟾泥 HBsAg 뼇꽦瑜좎 2.0%뿉 鍮꾪빐, 40, 50, 60뒗 3.4%, 3.9%, 3.5%濡 뿬쟾엳 넂븯쑝硫, 듅엳 씠 뿰졊쓽 궓꽦 뼇꽦瑜좎 4.0% 씠긽쑝濡 굹궗떎(KDCA, 2020). 씠 뿰援ъ뿉꽌 2019뀈 쑀蹂묐쪧 40, 50, 60뿉꽌 5.2%, 1.0%, 2.7%떎. 쟾援쓽 議곗궗 寃곌낵뒗 떖由 40~ 60 궓꽦쓽 룊洹 뼇꽦瑜좎 2.5%濡 쟾援쓽 40~60 궓꽦쓽 뼇꽦瑜좎씤 4.0%蹂대떎 궙븯쑝硫, 삤엳젮 30뿉꽌 4.0%쓽 뼇꽦瑜좎쓣 蹂댁떎.

B삎 媛꾩뿼 諛붿씠윭뒪뿉 븳 諛⑹뼱 뒫젰쓣 蹂댁뿬二쇰뒗 HBsAb 뼇꽦瑜좎 쟾泥 뿰援 湲곌컙 룞븞 43.1%濡 뿰룄뿉 뵲瑜 겙 李⑥씠뒗 뾾뿀怨, 궓옄 38.2%뿉 鍮꾪빐 뿬옄媛 46.7%濡 꽦蹂꾩뿉 쓽븳 李⑥씠瑜 蹂댁떎.

뿰졊蹂꾨줈뒗 10 씠븯뿉꽌 25.3%, 20 37.8%, 30 59.3%, 40 52.2%, 50 57.8%, 60 56.1%, 70 씠긽뿉꽌 49.1%濡 10 씠븯뿉꽌 媛옣 궙 寃껋쓣 蹂 닔 엳뿀떎.

10 씠븯 긽옄뒗 2001뀈 씠썑 異쒖깮옄씠誘濡 遺遺 삁諛 젒醫낆쓣 셿猷뚰븳 寃쎌슦씠誘濡 겕寃 臾몄젣릺吏 븡寃좎留, 吏뿭 듅꽦긽 遺遺꾩쓽 븰깮뱾씠 떎瑜 吏뿭뿉꽌 湲곗닕궗 깮솢쓣 븯뒗 젏쓣 怨좊젮븳떎硫, 異붽 젒醫낆쓣 븯뿬 B삎 媛꾩뿼 몴硫댄빆泥 蹂댁쑀 긽깭瑜 쑀吏떆耳 二쇰뒗 寃껋씠 븞쟾븯떎怨 뿬寃⑥쭊떎.

HBsAg 뼇꽦옄뱾쓽 HBV 愿젴 異붽 寃궗 寃곌낵瑜 넻븯뿬 B삎 媛꾩뿼 愿由ъ뿉 븳 긽솴쓣 媛꾩젒쟻쑝濡 쑀異뷀븷 닔 엳뿀떎. 異붽 寃궗瑜 諛쏆 뿰援 긽옄뒗 HBsAg 뼇꽦옄 124紐 以 40紐(32.3%)씠뿀떎. 留롮 뼇꽦옄뱾뿉 븳 愿由ш 씠猷⑥뼱吏吏 븡怨 엳쓬쓣 븣 닔 엳뼱 梨 留덈젴씠 븘슂븷 寃껋쑝濡 깮媛곷맂떎. HBeAg 寃곌낵瑜 넻빐 뼇꽦옄뱾쓽 異붽 닔寃瑜좎쓣 蹂대㈃, 10 씠븯뿉꽌 62.5%, 20 10.0%, 30 41.2%, 40 17.2%, 50 23.8%, 60 50.0%, 70 씠긽뿉꽌 41.4%瑜 蹂댁떎.

20媛 10.0%濡 異붽 빆紐⑹쓽 닔寃瑜좎씠 媛옣 궙븯怨, 넂 HBsAg 뼇꽦瑜좎쓣 蹂댁쑀븳 40뿉꽌룄 17.2%留뚯씠 異붽 寃궗瑜 떎떆븯떎.

씠 뿰援ш 湲곗닕궗슜 吏꾨떒꽌 諛쒓툒 愿젴 10, 梨꾩슜 愿젴 20, 吏꾨즺 愿젴 70꽭 씠긽 洹몃9泥섎읆 듅젙 洹몃9 긽옄 쐞二쇰줈 씠猷⑥뼱議뚭린 븣臾몄뿉 吏뿭 二쇰 쟾泥댁쓽 B삎 媛꾩뿼 뼇꽦瑜좎쓽 遺꾩꽍뿉뒗 븳怨꾧 엳뿀떎.

B삎 媛꾩뿼 쑀蹂묐쪧씠 留롮씠 궙븘議뚮떎怨 븯吏留, 쟾援쟻쑝濡 2016뀈遺꽣 湲됱꽦 B삎 媛꾩뿼 솚옄 닔쓽 利앷씪뒗 쐞뿕 떊샇 븿猿 B삎 媛꾩뿼怨 湲고 媛먯뿼蹂묒쓽 쑀蹂묐쪧씠 넂 遺곹븳 씠깉二쇰쇱씠굹 쇅援씤 洹쇰줈옄뱾쓽 씪넀씠 遺議깊븳 냽珥 吏뿭쑝濡쒖쓽 씠룞 B삎 媛꾩뿼 뼇꽦瑜 利앷쓽 옞옱쟻 쐞뿕 슂씤쑝濡쒖뜥 援곕쇱쓽 嫄닿컯뿉 쁺뼢쓣 誘몄튌 닔 엳쑝誘濡 듅蹂꾪븳 愿떖씠 븘슂븷 寃껋쑝濡 깮媛곷맂떎. 씠뱾뿉 븳 젙湲곗쟻씤 寃吏 벑쓣 넻븳 吏냽쟻씤 愿떖씠 吏뿭 궡 媛먯뿼 愿由 李⑥썝뿉꽌 븘슂븯硫, 쁽옱 援誘 嫄닿컯蹂댄뿕怨듬떒뿉꽌 떎떆븯怨 엳뒗 1뀈뿉 2쉶 寃吏꾩쓣 諛쏆쓣 닔 엳뒗 B삎 媛꾩뿼 蹂닿퇏옄쓽 媛꾩븫 寃吏 긽옄 벑濡앹뿉 븳 솉蹂댁 二쇰쇰뱾쓽 쟻洹뱀쟻씤 솢슜씠 븘슂븷 寃껋쑝濡 깮媛곷맂떎.

ACKNOWLEDGEMENT

None.

CONFLICT OF INTEREST

No potential conflict of interest relevant to this article was reported.

References
  1. Chae HB, Kim JH, Kim JK, et al. Current status of liver diseases in Korea hepatitis B. Korean Association for the Study of the Liver. 2009. 15: 13-24.
    Pubmed CrossRef
  2. Choung JM, Kim JC, Eun SH, et al. Study on Vaccination State in Children: Jeonbuk Province, 2000. The Korean Pediatric Society. 2002. 45: 1234-1240.
  3. Jang KM, Woo SH, Yun DH, et al. Seroepidemiologic Survey on Type B Viral Hepatitis in Inchon Area. Korean J Med. 1983. 26: 1331-1337.
  4. Jeong CW. 10-years of Hepatitis B Perinatal Transmission Prevention Program. Public Health Weekly Report. 2013. 6: 245-249.
  5. Kim SR, Kudo M, Hino O, et al. Epidemiology of hepatocellular carcinoma in Japan and Korea. Oncology. 2008. 75: 13-16.
    Pubmed CrossRef
  6. Korea Disease Control and Prevention Agency (KDCA). Infectious diseases surveillance yearbook. 2020. 12800079: p121.
  7. Seo K, Park SK, Park O. The prevalence of HBsAg positive parturients in Korea. Koean journal of Obstetrics and Gynecology. 2005. 48: 2119-2124.
  8. Statistics Korea. Cause-of-death statistics. 2021. 28: p4-48.
    CrossRef
  9. Stevens CE, Beasley RP, Tsui J, et al. Vertical transmission of hepatitis B antigen in Taiwan. N Engl J Med. 1975. 292: 771-774.
    Pubmed CrossRef
  10. WHO. Hepatitis B. 2021. 7: p27.
    CrossRef